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The map label for this gene is atoC [H]

Identifier: 117919788

GI number: 117919788

Start: 1553017

End: 1554357

Strand: Direct

Name: atoC [H]

Synonym: Shewana3_1340

Alternate gene names: 117919788

Gene position: 1553017-1554357 (Clockwise)

Preceding gene: 117919787

Following gene: 117919789

Centisome position: 31.23

GC content: 48.25

Gene sequence:

>1341_bases
ATGTCTGAAGCCAAATTACTCTTAGTCGAAGACGATGCCTCCCTGCGTGAGGCTTTGCTCGATACCTTAATGTTGGCGCA
ATACGACTGTATTGATGTGGCATCAGGTGAAGAAGCCATAATCGTACTAAAACAACATCAATTTGATCTTGTGATCAGCG
ATGTGCAAATGCAGGGGATTGGCGGCTTAGGCTTATTAAATTACTTACAGCAACATCATCCCAAATTGCCCGTGCTGTTA
ATGACGGCGTACGCCACTATAGGCAGTGCTGTCAGTGCAATTAAATTGGGCGCCGTCGATTATCTGGCAAAACCCTTCGC
TCCAGAGGTGTTGCTCAATCAAGTTTCCCGCTATTTACCACTCAAACAAAATAGCGATCAACCTGTGGTTGCCGATGAAA
AGAGTCTTGCGCTCTTGTCTCTGGCACAGCGGGTGGCAGCATCCGATGCTTCTGTGATGATCCTTGGGCCAAGTGGTTCG
GGTAAAGAAGTGTTAGCCCGTTATATTCATCAACATAGTAGCCGTGCTGACGAGGCCTTTGTGGCCATCAACTGTGCGGC
CATCCCCGAGAATATGCTTGAAGCCACATTATTTGGTTATGAAAAGGGCGCCTTTACCGGTGCTTACCAAGCTTGCCCCG
GTAAATTCGAACAAGCACAGGGCGGAACTTTATTACTCGATGAAATTTCAGAGATGGATTTAGGGTTACAGGCCAAACTG
CTGCGCGTATTGCAAGAGCGTGAAGTAGAGCGGTTAGGCGGCCGTAAAACCATCAAGCTGGATGTGAGAGTGCTAGCAAC
CTCAAATCGTGATTTAAAAGCCGTAGTTGCCGCGGGGCAATTTAGGGAAGATCTCTATTATCGCATTAACGTGTTTCCAT
TGACGTGGCCTGCGCTGAATCAACGGCCTGCGGATATTTTACCCTTAGCTCGGCATTTACTCACAAAACACGCAAAGGCA
CTGAGTATCATCGACGTACCCGAATTTGATGAGGCCGCATGCCGCCGTTTACTTGGCCATCGCTGGCCAGGTAATGTGCG
AGAGCTCGATAACGTTGTGCAGCGAGCCTTGATTTTGCGATCAGGTACGGTGATTACTGCCAATGACATTATTATTGATG
CTCAAGATGTGCCGTTATCATCCGATGATGCTGAATATTGCAGTGAGCCAGAGGGGTTAGGTGAAGAGTTAAAGGCGCAG
GAACATGTGATCATTCTCGAAACCCTAGCGCAATGCCAAGGCAGCCGTAAGTTGGTTGCTGAGAAACTAGGGATCAGCGC
GCGCACCTTAAGATACAAGATGGCCAGAATGCGCGATATGGGGATTCAATTGCCTAACTAA

Upstream 100 bases:

>100_bases
GGCCAACTGCAATTAAGCTGCATGCCCAATAAGGGTTGTACTGTGTCGCTAACCTTCCCGCAGGCGAAATCGGCTGCTGT
ATTGCCGCTGGAGAAACCCT

Downstream 100 bases:

>100_bases
GTCGAGTTTTGCAACCTTTCTAGCACCATCGCCACTGGTTATCCTTTGGCGATTTCACACCTATGACCTCTGCAATTCTT
TTTAGCTCGGCCAAGTAAAA

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIVLKQHQFDLVISDVQMQGIGGLGLLNYLQQHHPKLPVLL
MTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQNSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGS
GKEVLARYIHQHSSRADEAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALNQRPADILPLARHLLTKHAKA
LSIIDVPEFDEAACRRLLGHRWPGNVRELDNVVQRALILRSGTVITANDIIIDAQDVPLSSDDAEYCSEPEGLGEELKAQ
EHVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN

Sequences:

>Translated_446_residues
MSEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIVLKQHQFDLVISDVQMQGIGGLGLLNYLQQHHPKLPVLL
MTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQNSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGS
GKEVLARYIHQHSSRADEAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALNQRPADILPLARHLLTKHAKA
LSIIDVPEFDEAACRRLLGHRWPGNVRELDNVVQRALILRSGTVITANDIIIDAQDVPLSSDDAEYCSEPEGLGEELKAQ
EHVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN
>Mature_445_residues
SEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIVLKQHQFDLVISDVQMQGIGGLGLLNYLQQHHPKLPVLLM
TAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLPLKQNSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGSG
KEVLARYIHQHSSRADEAFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKLL
RVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALNQRPADILPLARHLLTKHAKAL
SIIDVPEFDEAACRRLLGHRWPGNVRELDNVVQRALILRSGTVITANDIIIDAQDVPLSSDDAEYCSEPEGLGEELKAQE
HVIILETLAQCQGSRKLVAEKLGISARTLRYKMARMRDMGIQLPN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=449, Percent_Identity=42.0935412026726, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=40.0447427293065, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1790299, Length=483, Percent_Identity=36.0248447204969, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1788905, Length=369, Percent_Identity=42.8184281842818, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI87082117, Length=311, Percent_Identity=45.6591639871383, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=42.5867507886435, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1789233, Length=315, Percent_Identity=41.2698412698413, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87082152, Length=234, Percent_Identity=47.4358974358974, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87081872, Length=302, Percent_Identity=37.7483443708609, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1786524, Length=227, Percent_Identity=46.6960352422907, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1787583, Length=319, Percent_Identity=35.1097178683386, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789828, Length=239, Percent_Identity=38.0753138075314, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI87081858, Length=315, Percent_Identity=29.2063492063492, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=35.3448275862069, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1790552, Length=123, Percent_Identity=32.520325203252, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48950; Mature: 48819

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIVLKQHQFDLVISDVQMQGI
CCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCEEEEEEEEECCC
GGLGLLNYLQQHHPKLPVLLMTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKQNSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGSGKEVLARYIHQHSSRADEAF
CCCCCCCCEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCEEHHHHHHHHCCEEEEEEEEEEECCCCC
QRPADILPLARHLLTKHAKALSIIDVPEFDEAACRRLLGHRWPGNVRELDNVVQRALILR
CCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
SGTVITANDIIIDAQDVPLSSDDAEYCSEPEGLGEELKAQEHVIILETLAQCQGSRKLVA
CCCEEEECCEEEECCCCCCCCCCHHHCCCCCCCCHHHHCCCCEEHHHHHHHCCCCHHHHH
EKLGISARTLRYKMARMRDMGIQLPN
HHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEAKLLLVEDDASLREALLDTLMLAQYDCIDVASGEEAIIVLKQHQFDLVISDVQMQGI
CCCEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCEEEEEEEEECCC
GGLGLLNYLQQHHPKLPVLLMTAYATIGSAVSAIKLGAVDYLAKPFAPEVLLNQVSRYLP
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LKQNSDQPVVADEKSLALLSLAQRVAASDASVMILGPSGSGKEVLARYIHQHSSRADEAF
CCCCCCCCEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEISEMDLGLQAKL
EEEEEHHCCHHHHHHHHHCCCCCCCCCCHHCCCCCCHHCCCCEEEEHHHHHCCCCHHHHH
LRVLQEREVERLGGRKTIKLDVRVLATSNRDLKAVVAAGQFREDLYYRINVFPLTWPALN
HHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCEEHHHHHHHHCCEEEEEEEEEEECCCCC
QRPADILPLARHLLTKHAKALSIIDVPEFDEAACRRLLGHRWPGNVRELDNVVQRALILR
CCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
SGTVITANDIIIDAQDVPLSSDDAEYCSEPEGLGEELKAQEHVIILETLAQCQGSRKLVA
CCCEEEECCEEEECCCCCCCCCCHHHCCCCCCCCHHHHCCCCEEHHHHHHHCCCCHHHHH
EKLGISARTLRYKMARMRDMGIQLPN
HHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]