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The map label for this gene is pepD [H]

Identifier: 117919399

GI number: 117919399

Start: 1111290

End: 1112753

Strand: Reverse

Name: pepD [H]

Synonym: Shewana3_0950

Alternate gene names: 117919399

Gene position: 1112753-1111290 (Counterclockwise)

Preceding gene: 117919405

Following gene: 117919381

Centisome position: 22.38

GC content: 50.0

Gene sequence:

>1464_bases
GTGACAGCGTTAAGTCAGTTATACCCACAGCCTTTATGGCAATGGTTCGAACAAATCTGTGCAATTCCCCACCCTTCCAA
ACATGAACAAGCACTCAGCCAACACATCCAAGCCTGGGCTAAGAGTAAACAACTCGATGTCGTGGAAGATGCGGTCGGCA
ATTTAATCATTCGCAAACCCGCAACCGCGGGAATGGAAGATCGCAAAATCGTCGTGATCCAAGCTCACATCGATATGGTG
CCGCAAAAGAATGCCGACAAAGTGCATGACTTTACCAAAGATCCTATCGAAGCCCATGTTGACGGTGACTGGGTAAAAGC
CAAAGGCACGACCTTAGGCGCCGACAATGGTATTGGCATGGCGTCGGCCTTAGCGATTTTAGGTAGCGACGACATCAAAC
ACGGCCCACTGGAAGTGCTGCTTACAATTGATGAAGAAGCGGGCATGACAGGCGCCTTCGGCCTGCAAGCGGGTATGCTG
GATGCTGAAATCCTGATCAATACCGACTCAGAGCAAGAAGGTGAAATCTACATGGGCTGCGCTGGCGGCGTCGATGCCCA
GATCACTCTGCCTATGGTATGGCAAGCGTCGGAGCAAAGTTACGCATCATTTAGCCTACATTTATCGGGCTTAAAAGGCG
GTCACTCAGGGGTGAACATCCATTTAGGTCGCGGTAATGCCAATAAGCTTCTGGCACGCTTCCTGTTTGAAAATGCTGAT
GAATTAGCGTTGGAATTAACCCAATTTACCGGTGGTTCACTGCGTAATGCCATCCCACGCGAAGCCAATATCAGCTTTAT
GTTACCCGCTGAAAATGTCGATGCACTGAATGAAAAAGTGCGTGCTTTTGAAGCCTTAGTCCGCGCTGAGCTGGCCATTG
CCGACCCAGACATGCGTTTAGTGTTGAGCGAAATCCCAACGCCAAAACGTGTGATGAGTGAAAACAGCCAAAACACGCTT
ATCGACCTGCTGCATGTATGCCCTAATGGCGTGATGCGTATGAGCGATGAAGTCGCGGGCGTGACCGAAACCTCACTCAA
CGTAGGCGTGATCAGCACTAATGATGAAGAAGTTAGCATTCTGTGCTTAATTCGCTCGCTCATCGATTCGGGCCGCACTC
AGGTTGAAGGCATGCTCAATGCACTGACCAACCTCGCTGGCGCTGAAATTGAATTCAGTGGCGCTTACCCAGGTTGGAAG
CCTGATAACAGCTCACCCGTAATGGCGATTGTGCGTGAGACCTACGAGTCTATCTACCATAAAGAACCTGTTATCATGGT
GATCCACGCGGGTCTTGAATGTGGTCTGTTCAAGAAGCCTTATCCAGAAATGGACATGGTGTCGATTGGCCCTACTATCC
GCTACCCACATGGCCCGGATGAAATGGTCAATATCACCACAGTTGGTCAATACTGGGATCTGCTCCTTGCTGTGCTAGAA
CGCATTCCCGCTAAAGGTGAATAA

Upstream 100 bases:

>100_bases
GCACACAGAGGCTTATCGAGAAGATTAATCGGCCGAGCAGAATGTGGTAGGATCAAGCCAAATTTGCCCTATACCCACAA
GACCTGATGAGGGACCTCCT

Downstream 100 bases:

>100_bases
TCACTCCAGCTGAATAGTCGCTAAGCAGACTTAAATAACAAAGGCCGCAGAGGGTTTACCAATGCGGCCTTTTTGTGGCT
TCTATTTGCGCACTGCGTAA

Product: M20C family Xaa-His dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLDVVEDAVGNLIIRKPATAGMEDRKIVVIQAHIDMV
PQKNADKVHDFTKDPIEAHVDGDWVKAKGTTLGADNGIGMASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGML
DAEILINTDSEQEGEIYMGCAGGVDAQITLPMVWQASEQSYASFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
ELALELTQFTGGSLRNAIPREANISFMLPAENVDALNEKVRAFEALVRAELAIADPDMRLVLSEIPTPKRVMSENSQNTL
IDLLHVCPNGVMRMSDEVAGVTETSLNVGVISTNDEEVSILCLIRSLIDSGRTQVEGMLNALTNLAGAEIEFSGAYPGWK
PDNSSPVMAIVRETYESIYHKEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHGPDEMVNITTVGQYWDLLLAVLE
RIPAKGE

Sequences:

>Translated_487_residues
MTALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLDVVEDAVGNLIIRKPATAGMEDRKIVVIQAHIDMV
PQKNADKVHDFTKDPIEAHVDGDWVKAKGTTLGADNGIGMASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGML
DAEILINTDSEQEGEIYMGCAGGVDAQITLPMVWQASEQSYASFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
ELALELTQFTGGSLRNAIPREANISFMLPAENVDALNEKVRAFEALVRAELAIADPDMRLVLSEIPTPKRVMSENSQNTL
IDLLHVCPNGVMRMSDEVAGVTETSLNVGVISTNDEEVSILCLIRSLIDSGRTQVEGMLNALTNLAGAEIEFSGAYPGWK
PDNSSPVMAIVRETYESIYHKEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHGPDEMVNITTVGQYWDLLLAVLE
RIPAKGE
>Mature_486_residues
TALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLDVVEDAVGNLIIRKPATAGMEDRKIVVIQAHIDMVP
QKNADKVHDFTKDPIEAHVDGDWVKAKGTTLGADNGIGMASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGMLD
AEILINTDSEQEGEIYMGCAGGVDAQITLPMVWQASEQSYASFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENADE
LALELTQFTGGSLRNAIPREANISFMLPAENVDALNEKVRAFEALVRAELAIADPDMRLVLSEIPTPKRVMSENSQNTLI
DLLHVCPNGVMRMSDEVAGVTETSLNVGVISTNDEEVSILCLIRSLIDSGRTQVEGMLNALTNLAGAEIEFSGAYPGWKP
DNSSPVMAIVRETYESIYHKEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHGPDEMVNITTVGQYWDLLLAVLER
IPAKGE

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=60.4123711340206, Blast_Score=605, Evalue=1e-174,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53021; Mature: 52890

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLDVVEDAVGNLIIRKP
CCCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEECC
ATAGMEDRKIVVIQAHIDMVPQKNADKVHDFTKDPIEAHVDGDWVKAKGTTLGADNGIGM
CCCCCCCCEEEEEEEEECCCCCCCCHHHHHCCCCCCEECCCCCEEEECCCEECCCCCCCH
ASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGMLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAQITLPMVWQASEQSYASFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
CCCCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCHH
ELALELTQFTGGSLRNAIPREANISFMLPAENVDALNEKVRAFEALVRAELAIADPDMRL
HHHHHHHHHCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCHHH
VLSEIPTPKRVMSENSQNTLIDLLHVCPNGVMRMSDEVAGVTETSLNVGVISTNDEEVSI
HHHHCCCCHHHHCCCCCHHHHHHHHHCCCCCEECCHHHCCCEECCEEEEEEECCCCCHHH
LCLIRSLIDSGRTQVEGMLNALTNLAGAEIEFSGAYPGWKPDNSSPVMAIVRETYESIYH
HHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
KEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHGPDEMVNITTVGQYWDLLLAVLE
CCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEEHHHHHHHHHHHHH
RIPAKGE
HCCCCCC
>Mature Secondary Structure 
TALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLDVVEDAVGNLIIRKP
CCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEECC
ATAGMEDRKIVVIQAHIDMVPQKNADKVHDFTKDPIEAHVDGDWVKAKGTTLGADNGIGM
CCCCCCCCEEEEEEEEECCCCCCCCHHHHHCCCCCCEECCCCCEEEECCCEECCCCCCCH
ASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGMLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAQITLPMVWQASEQSYASFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
CCCCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCHH
ELALELTQFTGGSLRNAIPREANISFMLPAENVDALNEKVRAFEALVRAELAIADPDMRL
HHHHHHHHHCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCHHH
VLSEIPTPKRVMSENSQNTLIDLLHVCPNGVMRMSDEVAGVTETSLNVGVISTNDEEVSI
HHHHCCCCHHHHCCCCCHHHHHHHHHCCCCCEECCHHHCCCEECCEEEEEEECCCCCHHH
LCLIRSLIDSGRTQVEGMLNALTNLAGAEIEFSGAYPGWKPDNSSPVMAIVRETYESIYH
HHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
KEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRYPHGPDEMVNITTVGQYWDLLLAVLE
CCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEEHHHHHHHHHHHHH
RIPAKGE
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]