Click here to switch to the map view.

The map label for this gene is tyrP [H]

Identifier: 117919361

GI number: 117919361

Start: 1063924

End: 1065099

Strand: Direct

Name: tyrP [H]

Synonym: Shewana3_0912

Alternate gene names: 117919361

Gene position: 1063924-1065099 (Clockwise)

Preceding gene: 117919359

Following gene: 117919362

Centisome position: 21.4

GC content: 51.11

Gene sequence:

>1176_bases
ATGTTAGGCTCGATAGCCATTGTCGCGGGGACCGCCATTGGCGCGGGAATGTTAGCCTTACCCTTAGCCACGGCCGCTTT
AGGCATGGTGCCAGCCATTTTGTTAATGGTGGTGATTTGGGGCTTGTCAGCCTATACCTCATTGTTAATGCTTGAGATTA
ACCTGCGCTCTGGCGTCGGTGATAACGTCCACGCTATCACGGGCAAACTCCTCGGCAAGAAAGGCCAAATGGTGCAAGGC
GCCTCATTTCTCAGCTTGCTCTTTGCTTTAACAGCAGCCTATTTGACGGGCGGCTCATCGCTGTTAGTGCTTAAAGCCAA
AAATATGTTCGACCTCGTGTTAGACAACCAACTGGCTGTGGTGCTGTTTACCTTAGTGTTGGGTGGATTTGCAGCCTTAG
GGGTGGCTTGGGTCGATAAAGCCTCGCGTTTCTTGTTTTCGCTGATGATTTTATTGCTGATTGTGGTCGTGCTGTTTTTA
TTACCCGAAGTCAGCATCTCGAGTATGGCAACCAGTGCGGTGGCCGAGTCCATGACCAGCAGTTGGATGGCGGCGATTCC
TGTGGTGTTTACCTCCTTCGGTTTCCACGTGTGTATCGCGACTTTAGTACGTTATTTGGATGGCGATGCTGTTTCGCTGC
GCAAAGTATTATTAATAGGTTCAACCATTCCACTCGCTTGTTATATCTTCTGGTTATTGGTGACTTTAGGCACTGTGGGG
GGCACCGAAATCAGCAGCTTTAATGGCTCTTTACCTGCGCTTATCAGTGCATTACAAGAGATTGCTCACACGCCTTGGAT
CAGCAAATGTATTTCGCTGTTTGCGGATTTAGCCTTAATCACCTCTTTCCTCGGGGTAACCTTAAGCCTGTATGATTTTG
TGGCTGAACTGACCCGCGCGAAGAAGACCTTCCTCGGCCGCGCTCAAACTTGGCTGTTAACCTTTGTGCCGCCGCTGTTA
TGTGCGCTCTATGTCCCCGAAGGTTTTGTTGCCGTATTAGGCTTTGCCGCCGTGCCGCTGGTGGTGATGATTATCTTCCT
GCCGATCGTGATGGCACTGCGTCAGCGCCAAGCTACGCCACAGGGATATCAAGTGTCCGGCGGGACATTTTCCCTCGGCA
TTGCCGGTCTGCTAGGCGCAGTGATTATCGGCGCTCAGCTATTTGTCGCGCTGTAA

Upstream 100 bases:

>100_bases
TTAATCACAGAGTGCGCAAGGCTTTATCCTTCAAATCTACTCAAAAAACCTTAAAAAATAATAATTAATACTTGAACAGG
ATAATTGTGTGAATTCAAAA

Downstream 100 bases:

>100_bases
CTTAAGGTTGTTTAATGCGCTGAAACGGTAGAGTGAAACCGATAATCTATGATGAATGTATTTGCTTTGTAAGCGAATTT
TTCTAACTCTGTTATAGAGT

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MLGSIAIVAGTAIGAGMLALPLATAALGMVPAILLMVVIWGLSAYTSLLMLEINLRSGVGDNVHAITGKLLGKKGQMVQG
ASFLSLLFALTAAYLTGGSSLLVLKAKNMFDLVLDNQLAVVLFTLVLGGFAALGVAWVDKASRFLFSLMILLLIVVVLFL
LPEVSISSMATSAVAESMTSSWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYIFWLLVTLGTVG
GTEISSFNGSLPALISALQEIAHTPWISKCISLFADLALITSFLGVTLSLYDFVAELTRAKKTFLGRAQTWLLTFVPPLL
CALYVPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQATPQGYQVSGGTFSLGIAGLLGAVIIGAQLFVAL

Sequences:

>Translated_391_residues
MLGSIAIVAGTAIGAGMLALPLATAALGMVPAILLMVVIWGLSAYTSLLMLEINLRSGVGDNVHAITGKLLGKKGQMVQG
ASFLSLLFALTAAYLTGGSSLLVLKAKNMFDLVLDNQLAVVLFTLVLGGFAALGVAWVDKASRFLFSLMILLLIVVVLFL
LPEVSISSMATSAVAESMTSSWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYIFWLLVTLGTVG
GTEISSFNGSLPALISALQEIAHTPWISKCISLFADLALITSFLGVTLSLYDFVAELTRAKKTFLGRAQTWLLTFVPPLL
CALYVPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQATPQGYQVSGGTFSLGIAGLLGAVIIGAQLFVAL
>Mature_391_residues
MLGSIAIVAGTAIGAGMLALPLATAALGMVPAILLMVVIWGLSAYTSLLMLEINLRSGVGDNVHAITGKLLGKKGQMVQG
ASFLSLLFALTAAYLTGGSSLLVLKAKNMFDLVLDNQLAVVLFTLVLGGFAALGVAWVDKASRFLFSLMILLLIVVVLFL
LPEVSISSMATSAVAESMTSSWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYIFWLLVTLGTVG
GTEISSFNGSLPALISALQEIAHTPWISKCISLFADLALITSFLGVTLSLYDFVAELTRAKKTFLGRAQTWLLTFVPPLL
CALYVPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQATPQGYQVSGGTFSLGIAGLLGAVIIGAQLFVAL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=393, Percent_Identity=40.9669211195929, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1790145, Length=386, Percent_Identity=28.4974093264249, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1789552, Length=358, Percent_Identity=27.3743016759777, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 41094; Mature: 41094

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSIAIVAGTAIGAGMLALPLATAALGMVPAILLMVVIWGLSAYTSLLMLEINLRSGVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
DNVHAITGKLLGKKGQMVQGASFLSLLFALTAAYLTGGSSLLVLKAKNMFDLVLDNQLAV
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHH
VLFTLVLGGFAALGVAWVDKASRFLFSLMILLLIVVVLFLLPEVSISSMATSAVAESMTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYIFWLLVTLGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
GTEISSFNGSLPALISALQEIAHTPWISKCISLFADLALITSFLGVTLSLYDFVAELTRA
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKTFLGRAQTWLLTFVPPLLCALYVPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQATP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QGYQVSGGTFSLGIAGLLGAVIIGAQLFVAL
CCEEECCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGSIAIVAGTAIGAGMLALPLATAALGMVPAILLMVVIWGLSAYTSLLMLEINLRSGVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
DNVHAITGKLLGKKGQMVQGASFLSLLFALTAAYLTGGSSLLVLKAKNMFDLVLDNQLAV
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHH
VLFTLVLGGFAALGVAWVDKASRFLFSLMILLLIVVVLFLLPEVSISSMATSAVAESMTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SWMAAIPVVFTSFGFHVCIATLVRYLDGDAVSLRKVLLIGSTIPLACYIFWLLVTLGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
GTEISSFNGSLPALISALQEIAHTPWISKCISLFADLALITSFLGVTLSLYDFVAELTRA
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKTFLGRAQTWLLTFVPPLLCALYVPEGFVAVLGFAAVPLVVMIIFLPIVMALRQRQATP
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QGYQVSGGTFSLGIAGLLGAVIIGAQLFVAL
CCEEECCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]