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The map label for this gene is cvrA [H]

Identifier: 117919299

GI number: 117919299

Start: 983483

End: 985207

Strand: Direct

Name: cvrA [H]

Synonym: Shewana3_0847

Alternate gene names: 117919299

Gene position: 983483-985207 (Clockwise)

Preceding gene: 117919295

Following gene: 117919301

Centisome position: 19.78

GC content: 51.94

Gene sequence:

>1725_bases
GTGGATGCAGATTCCATCAATAGTTTTTTTCTGATCGGTGCCTTGCTTGCCGCTGTGAGTGTTTTGTTAAGTCCCGTGTC
TTCGCGCTTGGGTATCCCTATCTTATTAATTTTCCTCGCTGTAGGGATTTTAGCTGGGGAGGATGGTCCCGGCGGTATTC
TGTTTGACGACTACTCAACCGCTTATCTTGTCAGTAACTTAGCCTTAGCCATTATCTTGCTCGATGGCGGTATGCGCACG
CGTGTCGCAAGCTTTAGGGTGGCACTGTGGCCAGCATTGTCGCTGGCGACCTTTGGGGTCGCTATCACCACCAGTATCAC
GGGCGTAATGGCCGCATGGTTATTTGACTTACACTGGTTGCAAGGCTTGCTGGTGGGGGCAATTGTCGGCTCCACCGATG
CGGCGGCGGTATTCTCGCTATTAAAGGGACGTAGTCTTAACGAGCGTGTTGGCGCGACGCTGGAAATCGAATCGGGCAGT
AACGACCCAATGGCGGTGTTTTTAACCGTAACCCTGATTGCCATCCTCGCTAATGTGGACGCCGAGTTATCCGTAAGCTT
TATGCTGATAAGCTTTATCAAGCAGTTTGGTTTGGGGATTTTCCTTGGTCTTGGCGGCGGTTGGCTGCTGTGGAAGTTGG
TGAATTTAAGCAAGCTTGCCGAAGGCTTGTATTCGATTTTAGTGCTCAGTGGCGGTCTGATGATTTATGCCGCCTCGAAC
AAACTCGGCGGTAGCGGCATCCTGTCGATTTATCTCGTCGGTCTCTTCCTCGGCAACAAGCCTACCCGCGGTCGCCATTC
CATCCTAAACGTATTGGATGGCATGACTTGGGTCAGCCAAATCGGTATGTTCCTCGTATTAGGGCTGCTGCTCACACCAT
CTGATTTGTTGGATATTTGGCTACCGGGCTTAGCGTTAGCCTTTGGGATGATCCTGTTTGCCAGACCGTTAGCTGTATGG
CTCAGCTTGCTGCCCTTTAAGAGCTTTAGCAGTCGTGACCGCTGGTTTATCTCTTGGGTCGGGCTTCGTGGCGCCGTGCC
GATTATTTTAGCGGTATTCCCTATGATGGCGGGATTACCAGGCGCTCAGTTGTACTTTAACTTGGCATTCTTCGTGGTGT
TAGTGTCACTGCTTGTGCAGGGGGCGTCACTCACCACGGCGGCGCGTTTAGCTAAGGTGGAGTTACCGCCTAAGCCGTTG
CCGATTTCACGTTCTGGGGTTGAAATATACCCGAGCAGTGAATGGGAAGTGTTTGTGTACCATCTGAGTGAAAACAAATG
GTGCATCGGCGAACCGCTTAAACGCCTCTCAATGCCAGATGGAACAAGGATTGCGGCGGTATTTCGCCATAATACGCTGT
TGCACCCATCGGGCAGTACCTGCCTCGAAGCGGGGGATATTTTGTGTGTGCTTGGGCAAGAGAAGAGCCTAGAAGCCTTA
AGTAACCTGTTTAGTCAGGCGCCCGAAACCAAGGAAGTGCCACGTTTCTTCGGTGACTTCTTTATCGATACCGAGGTTAA
GCTGCTGGATCTGGCGCCGATTTATGGGCTGGAGTTAGACGAAGCAACCGGCGACATGACGGTCGCAGATTTAGTAGCGG
CTGAATTAGGCTCGCATCCGGTACTTGGGGATCAGTTCCTATGGCAGTCGCTGCATTGGGTGGTTGCAGGGCTCAATGAA
GGCAAAGTCACCAATGTGGGTATTCGCTTACCGGCGGAGGCTTAA

Upstream 100 bases:

>100_bases
ATGCTAGTATAGAAACACAAAAATTTTCAATTGAGTCATTTTTAATCTAGGTGATTTCTTTATCGTTTAACTAAACACTC
TTGTATTTAAGGAGGCATGT

Downstream 100 bases:

>100_bases
GTGAAGCTGTATTGAAGTGCCTGCAATGCAGGGCTTCACTGGATATGGTTCTTGGTATTTCAAACCTTCAAAATGCCTTA
AACAAAACATCCAACAAAAA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MDADSINSFFLIGALLAAVSVLLSPVSSRLGIPILLIFLAVGILAGEDGPGGILFDDYSTAYLVSNLALAIILLDGGMRT
RVASFRVALWPALSLATFGVAITTSITGVMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGS
NDPMAVFLTVTLIAILANVDAELSVSFMLISFIKQFGLGIFLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLMIYAASN
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLLDIWLPGLALAFGMILFARPLAVW
LSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLVQGASLTTAARLAKVELPPKPL
PISRSGVEIYPSSEWEVFVYHLSENKWCIGEPLKRLSMPDGTRIAAVFRHNTLLHPSGSTCLEAGDILCVLGQEKSLEAL
SNLFSQAPETKEVPRFFGDFFIDTEVKLLDLAPIYGLELDEATGDMTVADLVAAELGSHPVLGDQFLWQSLHWVVAGLNE
GKVTNVGIRLPAEA

Sequences:

>Translated_574_residues
MDADSINSFFLIGALLAAVSVLLSPVSSRLGIPILLIFLAVGILAGEDGPGGILFDDYSTAYLVSNLALAIILLDGGMRT
RVASFRVALWPALSLATFGVAITTSITGVMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGS
NDPMAVFLTVTLIAILANVDAELSVSFMLISFIKQFGLGIFLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLMIYAASN
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLLDIWLPGLALAFGMILFARPLAVW
LSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLVQGASLTTAARLAKVELPPKPL
PISRSGVEIYPSSEWEVFVYHLSENKWCIGEPLKRLSMPDGTRIAAVFRHNTLLHPSGSTCLEAGDILCVLGQEKSLEAL
SNLFSQAPETKEVPRFFGDFFIDTEVKLLDLAPIYGLELDEATGDMTVADLVAAELGSHPVLGDQFLWQSLHWVVAGLNE
GKVTNVGIRLPAEA
>Mature_574_residues
MDADSINSFFLIGALLAAVSVLLSPVSSRLGIPILLIFLAVGILAGEDGPGGILFDDYSTAYLVSNLALAIILLDGGMRT
RVASFRVALWPALSLATFGVAITTSITGVMAAWLFDLHWLQGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGS
NDPMAVFLTVTLIAILANVDAELSVSFMLISFIKQFGLGIFLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLMIYAASN
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLLDIWLPGLALAFGMILFARPLAVW
LSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLPGAQLYFNLAFFVVLVSLLVQGASLTTAARLAKVELPPKPL
PISRSGVEIYPSSEWEVFVYHLSENKWCIGEPLKRLSMPDGTRIAAVFRHNTLLHPSGSTCLEAGDILCVLGQEKSLEAL
SNLFSQAPETKEVPRFFGDFFIDTEVKLLDLAPIYGLELDEATGDMTVADLVAAELGSHPVLGDQFLWQSLHWVVAGLNE
GKVTNVGIRLPAEA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=575, Percent_Identity=59.304347826087, Blast_Score=603, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61503; Mature: 61503

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDADSINSFFLIGALLAAVSVLLSPVSSRLGIPILLIFLAVGILAGEDGPGGILFDDYST
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCH
AYLVSNLALAIILLDGGMRTRVASFRVALWPALSLATFGVAITTSITGVMAAWLFDLHWL
HHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGSNDPMAVFLTVTLIAILANVD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
AELSVSFMLISFIKQFGLGIFLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLMIYAASN
CHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLLDIW
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LPGLALAFGMILFARPLAVWLSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
GAQLYFNLAFFVVLVSLLVQGASLTTAARLAKVELPPKPLPISRSGVEIYPSSEWEVFVY
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCCEEEEECCCCEEEEE
HLSENKWCIGEPLKRLSMPDGTRIAAVFRHNTLLHPSGSTCLEAGDILCVLGQEKSLEAL
EECCCCEECCCHHHHCCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEECCCCCHHHH
SNLFSQAPETKEVPRFFGDFFIDTEVKLLDLAPIYGLELDEATGDMTVADLVAAELGSHP
HHHHHCCCCCHHHHHHHHHHEECCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHCCCC
VLGDQFLWQSLHWVVAGLNEGKVTNVGIRLPAEA
CCCHHHHHHHHHHHHEECCCCCEEEEEEECCCCC
>Mature Secondary Structure
MDADSINSFFLIGALLAAVSVLLSPVSSRLGIPILLIFLAVGILAGEDGPGGILFDDYST
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCH
AYLVSNLALAIILLDGGMRTRVASFRVALWPALSLATFGVAITTSITGVMAAWLFDLHWL
HHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGSNDPMAVFLTVTLIAILANVD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCC
AELSVSFMLISFIKQFGLGIFLGLGGGWLLWKLVNLSKLAEGLYSILVLSGGLMIYAASN
CHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KLGGSGILSIYLVGLFLGNKPTRGRHSILNVLDGMTWVSQIGMFLVLGLLLTPSDLLDIW
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LPGLALAFGMILFARPLAVWLSLLPFKSFSSRDRWFISWVGLRGAVPIILAVFPMMAGLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
GAQLYFNLAFFVVLVSLLVQGASLTTAARLAKVELPPKPLPISRSGVEIYPSSEWEVFVY
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCCCEEEEECCCCEEEEE
HLSENKWCIGEPLKRLSMPDGTRIAAVFRHNTLLHPSGSTCLEAGDILCVLGQEKSLEAL
EECCCCEECCCHHHHCCCCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEECCCCCHHHH
SNLFSQAPETKEVPRFFGDFFIDTEVKLLDLAPIYGLELDEATGDMTVADLVAAELGSHP
HHHHHCCCCCHHHHHHHHHHEECCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHCCCC
VLGDQFLWQSLHWVVAGLNEGKVTNVGIRLPAEA
CCCHHHHHHHHHHHHEECCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA