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The map label for this gene is tpm

Identifier: 117919033

GI number: 117919033

Start: 680592

End: 681248

Strand: Direct

Name: tpm

Synonym: Shewana3_0580

Alternate gene names: 117919033

Gene position: 680592-681248 (Clockwise)

Preceding gene: 117919032

Following gene: 117919035

Centisome position: 13.69

GC content: 47.95

Gene sequence:

>657_bases
ATGGAACCCGGTTTTTGGCATGAGAAGTGGCAGCAACAGCTGATTGGTTTTCACCAGCAAGATATCAATCCCTTTCTCGT
AAAGTATTGGCATACCTTGGCATTGCCCGCCGGGGCCCAAGTCTTTGTTCCCCTGTGTGGCAAATCTTTAGATATGTGCT
TTTTAGCCGAGCAGGGGCATCAAGTGATTGGTTGTGAGTTAAATGAACTCGCAGTGCAGCAGTTTTTCGAAGATAACCAA
TTACCTATGCAGCAAAGCGCGCTGGGTGAACATCAGCATTATCACACCGAGCAGGTGAGTTTATATCAAGGTGATATCTT
TACTTTGCCCGCGTCTATTACGGGCAAGGTTAGTGGTTTTTATGATCGCGCCGCCTTGATTGCTTGGCCCGAGAGCATGC
GGGCGCAATACGCCAAGCAATTAGCGCAGTTATTGCCCCAGGGCAGCGTAGGTTTATTAGTGACACTCGATTACCCGCAA
GAGGCCTTAAGTGGGCCGCCTTTTGCGGTGTCACCAACTTGGGTGGAGACACATTTAAGTGACGATTTTGACATCCAACT
CTTGGATTGTCAGGACGTGCTTGCGGACAACCCAAGGTTTGTTAAGAAAGAAGTTCCTTGGCTGAATGAAGCAGCTTATC
TATTAAGACGCAGATAA

Upstream 100 bases:

>100_bases
CTGTTTACATCTCTATGATTAACTTACGGTATCTGAGATTTTGCATCCACCCGTGAATGCCATTAGAGTAAGGATAACTT
TAGTCATTTGAGATATACCT

Downstream 100 bases:

>100_bases
TCAGATTGCATCCCATTGAGCTCAAAGCATTTATGCTTTTTGGCTGAGTGGGATGTGTCATTAAGGGGTTATAAGATTAT
CGCAAAATAGGGGTATGCGC

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MEPGFWHEKWQQQLIGFHQQDINPFLVKYWHTLALPAGAQVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFEDNQ
LPMQQSALGEHQHYHTEQVSLYQGDIFTLPASITGKVSGFYDRAALIAWPESMRAQYAKQLAQLLPQGSVGLLVTLDYPQ
EALSGPPFAVSPTWVETHLSDDFDIQLLDCQDVLADNPRFVKKEVPWLNEAAYLLRRR

Sequences:

>Translated_218_residues
MEPGFWHEKWQQQLIGFHQQDINPFLVKYWHTLALPAGAQVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFEDNQ
LPMQQSALGEHQHYHTEQVSLYQGDIFTLPASITGKVSGFYDRAALIAWPESMRAQYAKQLAQLLPQGSVGLLVTLDYPQ
EALSGPPFAVSPTWVETHLSDDFDIQLLDCQDVLADNPRFVKKEVPWLNEAAYLLRRR
>Mature_218_residues
MEPGFWHEKWQQQLIGFHQQDINPFLVKYWHTLALPAGAQVFVPLCGKSLDMCFLAEQGHQVIGCELNELAVQQFFEDNQ
LPMQQSALGEHQHYHTEQVSLYQGDIFTLPASITGKVSGFYDRAALIAWPESMRAQYAKQLAQLLPQGSVGLLVTLDYPQ
EALSGPPFAVSPTWVETHLSDDFDIQLLDCQDVLADNPRFVKKEVPWLNEAAYLLRRR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=219, Percent_Identity=31.9634703196347, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_SHESA (A0KSQ0)

Other databases:

- EMBL:   CP000469
- RefSeq:   YP_868225.1
- ProteinModelPortal:   A0KSQ0
- SMR:   A0KSQ0
- STRING:   A0KSQ0
- GeneID:   4476541
- GenomeReviews:   CP000469_GR
- KEGG:   shn:Shewana3_0580
- NMPDR:   fig|94122.5.peg.725
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   SSP94122:SHEWANA3_0580-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24797; Mature: 24797

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPGFWHEKWQQQLIGFHQQDINPFLVKYWHTLALPAGAQVFVPLCGKSLDMCFLAEQGH
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCC
QVIGCELNELAVQQFFEDNQLPMQQSALGEHQHYHTEQVSLYQGDIFTLPASITGKVSGF
EEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCCCCH
YDRAALIAWPESMRAQYAKQLAQLLPQGSVGLLVTLDYPQEALSGPPFAVSPTWVETHLS
HHCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCCCCCHHEECCC
DDFDIQLLDCQDVLADNPRFVKKEVPWLNEAAYLLRRR
CCCCEEEECCHHHHCCCCCCHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MEPGFWHEKWQQQLIGFHQQDINPFLVKYWHTLALPAGAQVFVPLCGKSLDMCFLAEQGH
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCCC
QVIGCELNELAVQQFFEDNQLPMQQSALGEHQHYHTEQVSLYQGDIFTLPASITGKVSGF
EEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCCCCH
YDRAALIAWPESMRAQYAKQLAQLLPQGSVGLLVTLDYPQEALSGPPFAVSPTWVETHLS
HHCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCCCCCHHEECCC
DDFDIQLLDCQDVLADNPRFVKKEVPWLNEAAYLLRRR
CCCCEEEECCHHHHCCCCCCHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA