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The map label for this gene is ilvC [H]

Identifier: 117918812

GI number: 117918812

Start: 390117

End: 391595

Strand: Direct

Name: ilvC [H]

Synonym: Shewana3_0355

Alternate gene names: 117918812

Gene position: 390117-391595 (Clockwise)

Preceding gene: 117918810

Following gene: 117918813

Centisome position: 7.85

GC content: 47.94

Gene sequence:

>1479_bases
ATGGCTAACTATTTTAACTCTCTGAATTTACGTCAACAATTAGCACAGCTTGGCCAATGTCGTTTCATGGACCGTTCTGA
ATTCAGCGACGGCTGCAATTACATCAAAGATTGGAATATTGTTATTTTAGGTTGTGGTGCTCAGGGTCTTAACCAAGGTC
TGAACATGCGCGACTCTGGGCTGAATATTGCCTACGCTCTGCGCCCTGAAGCCATTGCTCAAAAACGTGCATCATGGCAA
AAAGCCACAGATAACGGTTTTAAAGTAGGTACTTTTGAAGAGCTGATCCCAACGGCGGATTTGGTATTGAACTTAACGCC
CGATAAGCAGCACTCCAATGTGGTTAGCGCTGTGATGCCACTGATGAAACAGGGCGCAACACTGTCTTATTCCCACGGTT
TTAACATCGTTGAAGAAGGCATGCAGATCCGCCCCGATATTACAGTTGTGATGGTAGCGCCTAAGTGTCCAGGCACCGAA
GTGCGTGAAGAATACAAGCGTGGTTTTGGTGTACCAACACTGATTGCCGTGCACCCAGAAAACGACCCTAATGGCGATGG
TTTAGAGATTGCCAAAGCCTATGCGAGTGCCACAGGTGGTGACCGCGCTGGCGTGTTGCAATCTTCCTTTATCGCCGAAG
TAAAATCGGATCTGATGGGCGAGCAAACCATTCTGTGCGGTATGTTGCAGACTGGCGCTATCTTAGGTTACGACAAGATG
GTGGCCGATGGTGTTGAACCTGGCTATGCCGCTAAGTTAATTCAACAAGGTTGGGAAACCGTGACCGAGGCGCTTAAGCA
CGGCGGTATCACCAATATGATGGACAGACTGTCTAATCCAGCCAAGATTAAAGCGTTTGAAATTGCAGAAGATTTAAAAG
AAATTCTGCAACCCTTATTCGAAAAACATATGGATGACATCATCAGCGGCGAGTTCTCCCGCACTATGATGCAAGACTGG
GCCAATGACGACGCTAACCTGCTGCGTTGGCGCGCCGAAACCGCCGAAACGGGCTTCGAAAATGCCCCAGTGTCGAGCGA
GCATATCGACGAGCAAACCTATTTCGACAAGGGGATTTTCCTGGTTGCGATGATCAAAGCCGGTGTCGAATTAGCCTTTG
ATACTATGGTGTCGGCGGGTATTGTTGAAGAGTCAGCCTATTACGAATCACTGCATGAAACGCCGCTGATCGCTAACACC
ATCGCCCGTAAACGTCTTTATGAGATGAACGTGGTGATCTCGGATACCGCAGAATACGGTTGTTATCTGTTCAACCATGC
TGCCGTGCCTATGCTGCGTGACTATGTAAATGCCATGTCGCCAGAGTATTTAGGTGCGGGTCTGAAGGACAGTTCAAACA
ACGTCGATAACCTGCAGTTAATCGCCATCAATGATGCGATTCGCCACACCTCAGTTGAGTATATCGGTGCGGAACTTCGT
GGTTATATGACTGATATGAAAAGTATTGTTGGAGCTTAA

Upstream 100 bases:

>100_bases
CGATAGCCATAGGTTATAGTGATTTCAATCACAACCAGTTATTAACAAAAAGTTGATATTGGTTGAGTCCCAAATTCCCG
ACTGAAAGGTGGTATCTCAG

Downstream 100 bases:

>100_bases
TCGATAGAGGCCGAGCCCCTAAGGATGTGGGGCTCGGCGTGACAAATTTATTCCTGCTTCGTAGGTTGTCGAGCGGGCAA
AACCGACATGGGTTAGTTGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSGLNIAYALRPEAIAQKRASWQ
KATDNGFKVGTFEELIPTADLVLNLTPDKQHSNVVSAVMPLMKQGATLSYSHGFNIVEEGMQIRPDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPNGDGLEIAKAYASATGGDRAGVLQSSFIAEVKSDLMGEQTILCGMLQTGAILGYDKM
VADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMQDW
ANDDANLLRWRAETAETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSPEYLGAGLKDSSNNVDNLQLIAINDAIRHTSVEYIGAELR
GYMTDMKSIVGA

Sequences:

>Translated_492_residues
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSGLNIAYALRPEAIAQKRASWQ
KATDNGFKVGTFEELIPTADLVLNLTPDKQHSNVVSAVMPLMKQGATLSYSHGFNIVEEGMQIRPDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPNGDGLEIAKAYASATGGDRAGVLQSSFIAEVKSDLMGEQTILCGMLQTGAILGYDKM
VADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMQDW
ANDDANLLRWRAETAETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSPEYLGAGLKDSSNNVDNLQLIAINDAIRHTSVEYIGAELR
GYMTDMKSIVGA
>Mature_491_residues
ANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSGLNIAYALRPEAIAQKRASWQK
ATDNGFKVGTFEELIPTADLVLNLTPDKQHSNVVSAVMPLMKQGATLSYSHGFNIVEEGMQIRPDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPNGDGLEIAKAYASATGGDRAGVLQSSFIAEVKSDLMGEQTILCGMLQTGAILGYDKMV
ADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMQDWA
NDDANLLRWRAETAETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTI
ARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSPEYLGAGLKDSSNNVDNLQLIAINDAIRHTSVEYIGAELRG
YMTDMKSIVGA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=489, Percent_Identity=72.5971370143149, Blast_Score=741, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=294, Percent_Identity=31.2925170068027, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54167; Mature: 54036

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSG
CCCCHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCC
LNIAYALRPEAIAQKRASWQKATDNGFKVGTFEELIPTADLVLNLTPDKQHSNVVSAVMP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQIRPDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPNGDGLEIAKAYASATGGDRAGVLQSSFIAEVKSDLMGEQTILCGMLQTGAILGYDKM
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEECHHHH
VADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMQDWANDDANLLRWRAETAETGFENAPVSSEHIDEQTYFDKGIF
HHHHHHHHCCHHHHHHHHHHCCCCHHHHEEEHHHHHCCCCCCCCCHHHCCHHHHHHCHHH
LVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCHHHC
CYLFNHAAVPMLRDYVNAMSPEYLGAGLKDSSNNVDNLQLIAINDAIRHTSVEYIGAELR
EEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
GYMTDMKSIVGA
HHHHHHHHHHCC
>Mature Secondary Structure 
ANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKDWNIVILGCGAQGLNQGLNMRDSG
CCCHHCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCC
LNIAYALRPEAIAQKRASWQKATDNGFKVGTFEELIPTADLVLNLTPDKQHSNVVSAVMP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHHH
LMKQGATLSYSHGFNIVEEGMQIRPDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHCCCEECCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPNGDGLEIAKAYASATGGDRAGVLQSSFIAEVKSDLMGEQTILCGMLQTGAILGYDKM
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEECHHHH
VADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMQDWANDDANLLRWRAETAETGFENAPVSSEHIDEQTYFDKGIF
HHHHHHHHCCHHHHHHHHHHCCCCHHHHEEEHHHHHCCCCCCCCCHHHCCHHHHHHCHHH
LVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCHHHC
CYLFNHAAVPMLRDYVNAMSPEYLGAGLKDSSNNVDNLQLIAINDAIRHTSVEYIGAELR
EEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHH
GYMTDMKSIVGA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]