Click here to switch to the map view.

The map label for this gene is bdhA [H]

Identifier: 117918762

GI number: 117918762

Start: 341231

End: 342307

Strand: Direct

Name: bdhA [H]

Synonym: Shewana3_0305

Alternate gene names: 117918762

Gene position: 341231-342307 (Clockwise)

Preceding gene: 117918761

Following gene: 117918763

Centisome position: 6.86

GC content: 50.51

Gene sequence:

>1077_bases
ATGAGCATGATGAATGCCCAAACCATGAAGGCAATCGTGATGCAGGACGGCGAAGTCACCCTGCAGCAAGTCGATTTACC
TAAACCACAGGTTGGCCAAGTGTTAGTTCGTAGCCTTGCCTGTGGTATCTGTGGTTCAGATATCCACATTACTCGCCACT
ACAGTGAAGTGTTTAGCTTCTACCGCAAGCTTGGCGTTATGCCAGAAGGCGTAGATGACCATGTACCTGTGATGCTTGGC
CATGAGTTCTGCGCTGAAGTGGTAGAATTCGGTCCGCAAACGCAACAAACATTAGCAGTCGGCACTCGCGTAACTTCAGT
ACCTATCCTGATGAGCCAAAATGGCGCTGGTGTCGGTGTTACCCCTGGTGTAAACGGTGCTTACTCTGAGTACTTCATTC
TCGATGAAGCCCTGTTAATGCCAGTGCCAGAGCATCTGCCGCCAGAAGCGGTTGCGCTGACTGAGCCATTAGCTGTGGGT
TTACATGCAGTAAACCGTGGTGATGTGGGCGTTGAAGACACTGCCTTAGTCGTGGGTTGTGGTCCTATCGGTTTAGCGGC
AATTTCTGCGCTTCACCTACGTGGTGTGCGCAATATTATTGCGGCCGACCTACAGGGCGAAAAACTGCAATTAGCCCGTG
AATTTGGTGCGACTCACACTGTGAACCCTGGTGAGCAGGACGAAGTCGCCTATGCCGCCGAAGTTGCCGAGGGTCATCGT
GTGGTGATTTTCGAATGCGTGGGTATTCACAAGTTGATTGAAGGCTTTGTGAAGCGTGCGCCAGCTAAGGCAACTATCGT
TGTGACCGGTATTCACACCGCAGAAGCGAATATCAACTACGCCTATGCCACAGTGAAAGAGCTGGATATGCGTTTCTCTT
ACTACTATCAGCCTGATGAATTCGCTGCCTGTTTAGCGGAATTAGCACAGGGCACTATTCCTTGGCGTAAGCTACTCACG
GGAAAAGTGGGGATGGATGGGGTATCGGGGGCATTCAAGCAATTAATGAAACCGAATCCACATATTAAGGTTGTGATTGA
ACCTTGGCGTAACGGCGAGTTGGAGACGCTCAACTAA

Upstream 100 bases:

>100_bases
CAAGCTGTTGTTGCTGCGGCTAAAGCGCAAGGCTTTACTGCTCGTTACATCAAACCAGGTGCTCAAGCGCGTATGAGCGA
CGCAGAATAAGGATTTGGCT

Downstream 100 bases:

>100_bases
TCGTTCAAAGCGCTCAATCAAATTAAGCCGCTAACTCATTTAGCGGCTTTTTTGTTCATTGTTACTATTTTTGTTATCCT
CAATTGGCTAATTTTTAATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSMMNAQTMKAIVMQDGEVTLQQVDLPKPQVGQVLVRSLACGICGSDIHITRHYSEVFSFYRKLGVMPEGVDDHVPVMLG
HEFCAEVVEFGPQTQQTLAVGTRVTSVPILMSQNGAGVGVTPGVNGAYSEYFILDEALLMPVPEHLPPEAVALTEPLAVG
LHAVNRGDVGVEDTALVVGCGPIGLAAISALHLRGVRNIIAADLQGEKLQLAREFGATHTVNPGEQDEVAYAAEVAEGHR
VVIFECVGIHKLIEGFVKRAPAKATIVVTGIHTAEANINYAYATVKELDMRFSYYYQPDEFAACLAELAQGTIPWRKLLT
GKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELETLN

Sequences:

>Translated_358_residues
MSMMNAQTMKAIVMQDGEVTLQQVDLPKPQVGQVLVRSLACGICGSDIHITRHYSEVFSFYRKLGVMPEGVDDHVPVMLG
HEFCAEVVEFGPQTQQTLAVGTRVTSVPILMSQNGAGVGVTPGVNGAYSEYFILDEALLMPVPEHLPPEAVALTEPLAVG
LHAVNRGDVGVEDTALVVGCGPIGLAAISALHLRGVRNIIAADLQGEKLQLAREFGATHTVNPGEQDEVAYAAEVAEGHR
VVIFECVGIHKLIEGFVKRAPAKATIVVTGIHTAEANINYAYATVKELDMRFSYYYQPDEFAACLAELAQGTIPWRKLLT
GKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELETLN
>Mature_357_residues
SMMNAQTMKAIVMQDGEVTLQQVDLPKPQVGQVLVRSLACGICGSDIHITRHYSEVFSFYRKLGVMPEGVDDHVPVMLGH
EFCAEVVEFGPQTQQTLAVGTRVTSVPILMSQNGAGVGVTPGVNGAYSEYFILDEALLMPVPEHLPPEAVALTEPLAVGL
HAVNRGDVGVEDTALVVGCGPIGLAAISALHLRGVRNIIAADLQGEKLQLAREFGATHTVNPGEQDEVAYAAEVAEGHRV
VIFECVGIHKLIEGFVKRAPAKATIVVTGIHTAEANINYAYATVKELDMRFSYYYQPDEFAACLAELAQGTIPWRKLLTG
KVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELETLN

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=347, Percent_Identity=24.7838616714697, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1787863, Length=347, Percent_Identity=26.5129682997118, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790045, Length=345, Percent_Identity=25.2173913043478, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=26.5671641791045, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=27.4143302180685, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=23.6311239193084, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=330, Percent_Identity=26.3636363636364, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87082125, Length=252, Percent_Identity=27.3809523809524, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=21.5469613259669, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=27.7008310249307, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562878, Length=348, Percent_Identity=27.5862068965517, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=367, Percent_Identity=28.3378746594005, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=27.4011299435028, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319955, Length=354, Percent_Identity=27.4011299435028, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=354, Percent_Identity=26.271186440678, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=25.1336898395722, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=137, Percent_Identity=32.1167883211679, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17137530, Length=351, Percent_Identity=26.7806267806268, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17737897, Length=349, Percent_Identity=26.647564469914, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 38606; Mature: 38475

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMMNAQTMKAIVMQDGEVTLQQVDLPKPQVGQVLVRSLACGICGSDIHITRHYSEVFSF
CCCCCHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
YRKLGVMPEGVDDHVPVMLGHEFCAEVVEFGPQTQQTLAVGTRVTSVPILMSQNGAGVGV
HHHHCCCCCCCCCCCCEEECHHHHHHHHHCCCCCHHHHHHCCEEEEEEEEEECCCCCCCC
TPGVNGAYSEYFILDEALLMPVPEHLPPEAVALTEPLAVGLHAVNRGDVGVEDTALVVGC
CCCCCCCCCCEEEECHHHHCCCCCCCCCCHHHHCCHHHHHHEECCCCCCCCCCCEEEEEC
GPIGLAAISALHLRGVRNIIAADLQGEKLQLAREFGATHTVNPGEQDEVAYAAEVAEGHR
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCE
VVIFECVGIHKLIEGFVKRAPAKATIVVTGIHTAEANINYAYATVKELDMRFSYYYQPDE
EEEEEECCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEHHHHHHHCEEEEEECCHH
FAACLAELAQGTIPWRKLLTGKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELETLN
HHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCEECC
>Mature Secondary Structure 
SMMNAQTMKAIVMQDGEVTLQQVDLPKPQVGQVLVRSLACGICGSDIHITRHYSEVFSF
CCCCHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
YRKLGVMPEGVDDHVPVMLGHEFCAEVVEFGPQTQQTLAVGTRVTSVPILMSQNGAGVGV
HHHHCCCCCCCCCCCCEEECHHHHHHHHHCCCCCHHHHHHCCEEEEEEEEEECCCCCCCC
TPGVNGAYSEYFILDEALLMPVPEHLPPEAVALTEPLAVGLHAVNRGDVGVEDTALVVGC
CCCCCCCCCCEEEECHHHHCCCCCCCCCCHHHHCCHHHHHHEECCCCCCCCCCCEEEEEC
GPIGLAAISALHLRGVRNIIAADLQGEKLQLAREFGATHTVNPGEQDEVAYAAEVAEGHR
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCE
VVIFECVGIHKLIEGFVKRAPAKATIVVTGIHTAEANINYAYATVKELDMRFSYYYQPDE
EEEEEECCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEHHHHHHHCEEEEEECCHH
FAACLAELAQGTIPWRKLLTGKVGMDGVSGAFKQLMKPNPHIKVVIEPWRNGELETLN
HHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]