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The map label for this gene is aroE

Identifier: 117918502

GI number: 117918502

Start: 48638

End: 49516

Strand: Direct

Name: aroE

Synonym: Shewana3_0043

Alternate gene names: 117918502

Gene position: 48638-49516 (Clockwise)

Preceding gene: 117918500

Following gene: 117918503

Centisome position: 0.98

GC content: 51.76

Gene sequence:

>879_bases
ATGACAGATATGCCCTCAGTAACTACGCCAGCGCTTGATCGATATGCCGTGTTTGGCAATCCGATAGGTCACAGTAAATC
GCCCTTTATTCATGGACAGTTTGCGTCTCTTACACAGCAGACTTTGAGTTATGAAGCGATTCTGGCGCCCATAGATGGTT
TTGAAGCGAGTTTACGAGCATTTTTTCAGGCGGGAGGAAAGGGCGCGAATGTGACTGTGCCCTTTAAAGAGCAAGCCTTT
GCCCTCTGCGACAGCTTAAGTGCCGAAGCGACATTGGCGGGTGCGGTCAATACTCTAAGCTTGTTGGCCGATGGCACTAT
TTACGGTGATAACACCGATGGTCTGGGGCTGGTGGCCGATCTTGTTCGCCATCTCGGCAGTTTGCAGCATAAGCGGGTAC
TCTTGGTGGGGGCCGGCGGTGCGGCGCGCGGCTGTATCTTGCCATTGCTCAAGGCTGAAGTCGGGCAATTGGTTATCACT
AACCGAACCCAAAGTAAGGCACAGGCCTTAGTGGATATTTTCAGCCAAGTACAAGAAGGGCGCTACAGCGATAAACTCCA
GGCTGTATCGATGTCAGAGTTGTCGGGGGTGTTCGATTTAGTGATTAACTCGACCTCAGCGAGTCTAGCGGGAGAGTTAC
CGCCACTGTCACAGTCCATCATAGGCAACAAAACGGCTTGCTACGATATGATGTATGGCGCCAAACCAACAGCATTTAAT
CAATGGGCTTTGCAACAGGGTGCAGCGCAAGTGATTGATGGACTGGGTATGCTTGTCGGTCAAGCGGCGAAGAGTTTTGC
ACTTTGGCGTGGCGTCGAGCCAGATACCTCAGGAGTGCTTAAATTGCTCAGGGACAAACTGCAGGTCGACGCGCAATAG

Upstream 100 bases:

>100_bases
GCTAAAGTCAGGTACAACAACTTAGACTCGCCATTAAGCTGTGCTACCGCCTAAAAGCACGCTAGACTGCAAGCCACTTA
CAGCCAATAGAATCCCGCAG

Downstream 100 bases:

>100_bases
AGGCTCAAGAGGAAGAGAAGATGAATCAGAGTATTTTATTCCCCGATCTGCAACATTGGGATGAAACCCAAAAACACATT
TGCTTTATTGCCCAGCAGCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTDMPSVTTPALDRYAVFGNPIGHSKSPFIHGQFASLTQQTLSYEAILAPIDGFEASLRAFFQAGGKGANVTVPFKEQAF
ALCDSLSAEATLAGAVNTLSLLADGTIYGDNTDGLGLVADLVRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVIT
NRTQSKAQALVDIFSQVQEGRYSDKLQAVSMSELSGVFDLVINSTSASLAGELPPLSQSIIGNKTACYDMMYGAKPTAFN
QWALQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQVDAQ

Sequences:

>Translated_292_residues
MTDMPSVTTPALDRYAVFGNPIGHSKSPFIHGQFASLTQQTLSYEAILAPIDGFEASLRAFFQAGGKGANVTVPFKEQAF
ALCDSLSAEATLAGAVNTLSLLADGTIYGDNTDGLGLVADLVRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVIT
NRTQSKAQALVDIFSQVQEGRYSDKLQAVSMSELSGVFDLVINSTSASLAGELPPLSQSIIGNKTACYDMMYGAKPTAFN
QWALQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQVDAQ
>Mature_291_residues
TDMPSVTTPALDRYAVFGNPIGHSKSPFIHGQFASLTQQTLSYEAILAPIDGFEASLRAFFQAGGKGANVTVPFKEQAFA
LCDSLSAEATLAGAVNTLSLLADGTIYGDNTDGLGLVADLVRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVITN
RTQSKAQALVDIFSQVQEGRYSDKLQAVSMSELSGVFDLVINSTSASLAGELPPLSQSIIGNKTACYDMMYGAKPTAFNQ
WALQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQVDAQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=277, Percent_Identity=51.6245487364621, Blast_Score=270, Evalue=6e-74,
Organism=Escherichia coli, GI1787983, Length=277, Percent_Identity=26.3537906137184, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320332, Length=167, Percent_Identity=33.5329341317365, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_SHESA (A0KR69)

Other databases:

- EMBL:   CP000469
- RefSeq:   YP_867694.1
- ProteinModelPortal:   A0KR69
- SMR:   A0KR69
- STRING:   A0KR69
- GeneID:   4478915
- GenomeReviews:   CP000469_GR
- KEGG:   shn:Shewana3_0043
- NMPDR:   fig|94122.5.peg.231
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   CEITITN
- PhylomeDB:   A0KR69
- ProtClustDB:   PRK00258
- BioCyc:   SSP94122:SHEWANA3_0043-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30732; Mature: 30601

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: ACT_SITE 76-76

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMPSVTTPALDRYAVFGNPIGHSKSPFIHGQFASLTQQTLSYEAILAPIDGFEASLRA
CCCCCCCCCCCHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHEEECCCCHHHHHHH
FFQAGGKGANVTVPFKEQAFALCDSLSAEATLAGAVNTLSLLADGTIYGDNTDGLGLVAD
HHHCCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHH
LVRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVITNRTQSKAQALVDIFSQVQEG
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCC
RYSDKLQAVSMSELSGVFDLVINSTSASLAGELPPLSQSIIGNKTACYDMMYGAKPTAFN
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHCCCHHHHHHHHCCCCCCHH
QWALQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQVDAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDMPSVTTPALDRYAVFGNPIGHSKSPFIHGQFASLTQQTLSYEAILAPIDGFEASLRA
CCCCCCCCCCHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHEEECCCCHHHHHHH
FFQAGGKGANVTVPFKEQAFALCDSLSAEATLAGAVNTLSLLADGTIYGDNTDGLGLVAD
HHHCCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHH
LVRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVITNRTQSKAQALVDIFSQVQEG
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCC
RYSDKLQAVSMSELSGVFDLVINSTSASLAGELPPLSQSIIGNKTACYDMMYGAKPTAFN
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHCCCHHHHHHHHCCCCCCHH
QWALQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQVDAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA