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The map label for this gene is ldh [H]

Identifier: 116872452

GI number: 116872452

Start: 1050169

End: 1051122

Strand: Direct

Name: ldh [H]

Synonym: lwe1034

Alternate gene names: 116872452

Gene position: 1050169-1051122 (Clockwise)

Preceding gene: 116872451

Following gene: 116872453

Centisome position: 37.32

GC content: 35.32

Gene sequence:

>954_bases
ATGGCATCTAAGAAGAAAAAAATTGTCGTTATTGGAAGAAGCAATCTACAAAATCTCTATATTCATACAGTTCTTTTAAA
AAAGCTTACAGCCGAGATATATTTAATAGATGATCAAGCTAAAACAAGCGTTCAGGACTTTGAATATGCAAGTTACTATC
ATTCAGCTACAACGATTAACAATGGTACTTTTAATGAATGTCGAAACGCTGATATAGTCGTTTTTTTTCAAGAAGAAATG
TCGAATGCTTCGTTTTCCAATGAAGAGAATGTAACCTTAATCAAAGAAAAAGTGAAAAAAATGATGGCAACTGGTTTTCA
AGGAATCGTCTTAGTAGCAACTGCTGAAAGTAATGTGGTTGCATCTTTAATAAAACGCTATTCTGGTTTACCTGCCAACC
AAATTTTGACACTTGGCACTATGCTTGCGACTTCTTATTTTCAAGTTGAAATTGCTAAATTATTTAAAATTAGCCCCAAA
AATGTTCATGGATATATTATTGGTGATAATGCGAATGACGTTATACCTGTGTGGAGCAGAGCGTTCCTTGGAGGCAAGCC
AATTTTAAGTTATTTAGCCGAAGAACAAAAAAGAATCACCTCAGATGACTTACAAAATTTAACAAAAATGATTACTCGGA
TTCCTGATTTTCCTTTTGAGAATAAAGATGGCTGTACGTTCCGTTTTAGTACGGTAACCGTTCTTGCTGAATTAACCGAA
GTCATTTTACGGGATGAAGCTAGAGTTCTTACAGTAGGCGTAGAGGTGAAAGAGGCATATGGCTTAGAAACCCCAGTTTT
TATTAGTGTACCAGCTGTTATTGGCGCTGAAGGAGTGAGAGAATTACTTGAGCTAAATCTATCCGATGATGAACAAAAAG
AATTAAAGCAAATCGCCACAAAAACGACCGAGAAATTGGATGTACTACAGCTTAACAAGGGAGGAATTAGTTAA

Upstream 100 bases:

>100_bases
GCGAATGAGCGATGCTTTTTATTTATGCGGTCAAGTTATTTTATTCTGACTCTTAGGCATGCTAAAATGATATAAGAGAC
TTGATGAGGAGGAGATGGAT

Downstream 100 bases:

>100_bases
TGGAATATAGTTATCCACTAAATCCAGACTGGACAACGGAAGAAATGACGATTGTTGTACAATTTTTAGAAGCTATCGAA
CGAGCATATGAAAAAGGCAT

Product: lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MASKKKKIVVIGRSNLQNLYIHTVLLKKLTAEIYLIDDQAKTSVQDFEYASYYHSATTINNGTFNECRNADIVVFFQEEM
SNASFSNEENVTLIKEKVKKMMATGFQGIVLVATAESNVVASLIKRYSGLPANQILTLGTMLATSYFQVEIAKLFKISPK
NVHGYIIGDNANDVIPVWSRAFLGGKPILSYLAEEQKRITSDDLQNLTKMITRIPDFPFENKDGCTFRFSTVTVLAELTE
VILRDEARVLTVGVEVKEAYGLETPVFISVPAVIGAEGVRELLELNLSDDEQKELKQIATKTTEKLDVLQLNKGGIS

Sequences:

>Translated_317_residues
MASKKKKIVVIGRSNLQNLYIHTVLLKKLTAEIYLIDDQAKTSVQDFEYASYYHSATTINNGTFNECRNADIVVFFQEEM
SNASFSNEENVTLIKEKVKKMMATGFQGIVLVATAESNVVASLIKRYSGLPANQILTLGTMLATSYFQVEIAKLFKISPK
NVHGYIIGDNANDVIPVWSRAFLGGKPILSYLAEEQKRITSDDLQNLTKMITRIPDFPFENKDGCTFRFSTVTVLAELTE
VILRDEARVLTVGVEVKEAYGLETPVFISVPAVIGAEGVRELLELNLSDDEQKELKQIATKTTEKLDVLQLNKGGIS
>Mature_316_residues
ASKKKKIVVIGRSNLQNLYIHTVLLKKLTAEIYLIDDQAKTSVQDFEYASYYHSATTINNGTFNECRNADIVVFFQEEMS
NASFSNEENVTLIKEKVKKMMATGFQGIVLVATAESNVVASLIKRYSGLPANQILTLGTMLATSYFQVEIAKLFKISPKN
VHGYIIGDNANDVIPVWSRAFLGGKPILSYLAEEQKRITSDDLQNLTKMITRIPDFPFENKDGCTFRFSTVTVLAELTEV
ILRDEARVLTVGVEVKEAYGLETPVFISVPAVIGAEGVRELLELNLSDDEQKELKQIATKTTEKLDVLQLNKGGIS

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI9257228, Length=303, Percent_Identity=24.4224422442244, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4504973, Length=303, Percent_Identity=24.4224422442244, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI291575128, Length=301, Percent_Identity=24.2524916943522, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI4557032, Length=301, Percent_Identity=24.2524916943522, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI15082234, Length=313, Percent_Identity=23.3226837060703, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI260099723, Length=307, Percent_Identity=22.8013029315961, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI5031857, Length=307, Percent_Identity=23.1270358306189, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI47059044, Length=306, Percent_Identity=22.5490196078431, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI221136809, Length=306, Percent_Identity=22.5490196078431, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI207028494, Length=216, Percent_Identity=24.537037037037, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17535107, Length=293, Percent_Identity=20.4778156996587, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550422, Length=303, Percent_Identity=23.7623762376238, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17136226, Length=316, Percent_Identity=23.1012658227848, Blast_Score=94, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 35274; Mature: 35143

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKKKKIVVIGRSNLQNLYIHTVLLKKLTAEIYLIDDQAKTSVQDFEYASYYHSATTIN
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCCEEEC
NGTFNECRNADIVVFFQEEMSNASFSNEENVTLIKEKVKKMMATGFQGIVLVATAESNVV
CCCCHHHCCCCEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
ASLIKRYSGLPANQILTLGTMLATSYFQVEIAKLFKISPKNVHGYIIGDNANDVIPVWSR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCEEEEEEECCCCCEEHHHHH
AFLGGKPILSYLAEEQKRITSDDLQNLTKMITRIPDFPFENKDGCTFRFSTVTVLAELTE
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHH
VILRDEARVLTVGVEVKEAYGLETPVFISVPAVIGAEGVRELLELNLSDDEQKELKQIAT
HHHCCCCEEEEEEEEEHHHCCCCCCEEEECCHHHCHHHHHHHHHCCCCCCHHHHHHHHHH
KTTEKLDVLQLNKGGIS
HHHHHEEEEEECCCCCC
>Mature Secondary Structure 
ASKKKKIVVIGRSNLQNLYIHTVLLKKLTAEIYLIDDQAKTSVQDFEYASYYHSATTIN
CCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHCCEEEC
NGTFNECRNADIVVFFQEEMSNASFSNEENVTLIKEKVKKMMATGFQGIVLVATAESNVV
CCCCHHHCCCCEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
ASLIKRYSGLPANQILTLGTMLATSYFQVEIAKLFKISPKNVHGYIIGDNANDVIPVWSR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCEEEEEEECCCCCEEHHHHH
AFLGGKPILSYLAEEQKRITSDDLQNLTKMITRIPDFPFENKDGCTFRFSTVTVLAELTE
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHH
VILRDEARVLTVGVEVKEAYGLETPVFISVPAVIGAEGVRELLELNLSDDEQKELKQIAT
HHHCCCCEEEEEEEEEHHHCCCCCCEEEECCHHHCHHHHHHHHHCCCCCCHHHHHHHHHH
KTTEKLDVLQLNKGGIS
HHHHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6352452; 3026926; 3675869; 6618448; 1731077 [H]