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The map label for this gene is moeA [H]

Identifier: 116872437

GI number: 116872437

Start: 1037404

End: 1038627

Strand: Direct

Name: moeA [H]

Synonym: lwe1019

Alternate gene names: 116872437

Gene position: 1037404-1038627 (Clockwise)

Preceding gene: 116872436

Following gene: 116872438

Centisome position: 36.86

GC content: 37.91

Gene sequence:

>1224_bases
TTGATTGAAAAACGAAATACCATAAGTGTGGAGCAAGCCAGAGAAGTATTATGTAACCAAATAACGCATCTTCCAGTAGA
AAGAAAAATCGTAACAGAAGCATTAAATCAAGTTTTACAAGAGCCTGTTTTTGCCCCATTTCCTGCTCCTTATTTTAGAC
GTTCTGGTTATGATGGGTTTGCAATTACAGAAGCAGATGACGGGAATTATCCAATTAGACTACATGTTGTTGCAGAAGTT
CCTTGTGGAAAAACATATGATAAACCATTAAATCCAGGAGAAACGGTCCGAATAATGACTGGGGCAAAAGTGCCTGATAA
CGCAGCAAAAATTATTATGCTTGAACAATCAAGAAATGCTGATAAAGAAAACGAAATTATTCTTATTAATACACAAAAGT
CTAGTAACATTACAGAAATTGGTGCAGAGTTTGCGAAAGGCGATTTGCTGCTAGATCGTGGCCATATTTTGAATGCTGGA
TCAATAAGTTTATTGTCCTCATTTGGAATTCATGAAGTGCAAGTAATAAAAAAACCTAAAGTTGCAATTTTATCTACAGG
TAGTGAACTCATTTCTGCTGGAAATCCGCTTCCTGATGGCAAAATTTACAATAGTAATCAGCCGCTTCTTGAGAACTTAT
TAAAAGTACATCATGCAGAAATTTGTGTCGCCGAACAATTACCTGACAACTATGAAGATACAAAAAAACGCTTGCTGGAA
CTGACAGAAATAGCTGATTTAATTATTACAACTGGCGGTGTTTCTGTAGGGGATTATGACTTTATGGCCGATATCGCGAA
ACAAGAAGCGGAATTACTTTTTAATAAAATTCAAATGCGACCAGGCAGTCCGACAACTGGAATGTGGTTGAATCAGACGC
TTATTATTGCTCTTTCTGGAAATCCAGGGGCTTGCTTTACAGGTTTTTACTTGTTAGTAGAGCCTGTATTAGCAACTTTA
ATGGGAAAAGATACAACGGCGACTACCAAAGTGCGTGCTAAGATGGCGAGTGACTATACGAAAAATAATGGTTATGATCG
TTTTTTACGCGGGACGTATCGTTTATCAGACGAAGGGGAATATTTGGTTGATTTGGTAGGTAGCGACATGTCTAGTGCAC
TCGGAAACCTTCATCTTACTACCTGTTTATTTAAAATCCCACGAGGGCAAGTTGGAAAATTCAAAGGAGAAGAGGTCGAA
GCATGGCTACTATCCTCCAAGTAA

Upstream 100 bases:

>100_bases
AAGTAGTAAGGAGTCGCTTTACTTTTTAAAATAAGAAAACTCCTGTATATTGGTACTAAAGAAAACGCATACATGATTTG
TAGAAGGGAAGTGCGCCCAG

Downstream 100 bases:

>100_bases
TCGGTTTTAAAAACAGTGGTAAAACAACTTTAATAAATGCACTTATTAAAGCTAGTCATAAAGAAAACTATACGGTTTCT
GCCATCAAACATGATGCGCA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MIEKRNTISVEQAREVLCNQITHLPVERKIVTEALNQVLQEPVFAPFPAPYFRRSGYDGFAITEADDGNYPIRLHVVAEV
PCGKTYDKPLNPGETVRIMTGAKVPDNAAKIIMLEQSRNADKENEIILINTQKSSNITEIGAEFAKGDLLLDRGHILNAG
SISLLSSFGIHEVQVIKKPKVAILSTGSELISAGNPLPDGKIYNSNQPLLENLLKVHHAEICVAEQLPDNYEDTKKRLLE
LTEIADLIITTGGVSVGDYDFMADIAKQEAELLFNKIQMRPGSPTTGMWLNQTLIIALSGNPGACFTGFYLLVEPVLATL
MGKDTTATTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGEYLVDLVGSDMSSALGNLHLTTCLFKIPRGQVGKFKGEEVE
AWLLSSK

Sequences:

>Translated_407_residues
MIEKRNTISVEQAREVLCNQITHLPVERKIVTEALNQVLQEPVFAPFPAPYFRRSGYDGFAITEADDGNYPIRLHVVAEV
PCGKTYDKPLNPGETVRIMTGAKVPDNAAKIIMLEQSRNADKENEIILINTQKSSNITEIGAEFAKGDLLLDRGHILNAG
SISLLSSFGIHEVQVIKKPKVAILSTGSELISAGNPLPDGKIYNSNQPLLENLLKVHHAEICVAEQLPDNYEDTKKRLLE
LTEIADLIITTGGVSVGDYDFMADIAKQEAELLFNKIQMRPGSPTTGMWLNQTLIIALSGNPGACFTGFYLLVEPVLATL
MGKDTTATTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGEYLVDLVGSDMSSALGNLHLTTCLFKIPRGQVGKFKGEEVE
AWLLSSK
>Mature_407_residues
MIEKRNTISVEQAREVLCNQITHLPVERKIVTEALNQVLQEPVFAPFPAPYFRRSGYDGFAITEADDGNYPIRLHVVAEV
PCGKTYDKPLNPGETVRIMTGAKVPDNAAKIIMLEQSRNADKENEIILINTQKSSNITEIGAEFAKGDLLLDRGHILNAG
SISLLSSFGIHEVQVIKKPKVAILSTGSELISAGNPLPDGKIYNSNQPLLENLLKVHHAEICVAEQLPDNYEDTKKRLLE
LTEIADLIITTGGVSVGDYDFMADIAKQEAELLFNKIQMRPGSPTTGMWLNQTLIIALSGNPGACFTGFYLLVEPVLATL
MGKDTTATTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGEYLVDLVGSDMSSALGNLHLTTCLFKIPRGQVGKFKGEEVE
AWLLSSK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=390, Percent_Identity=28.974358974359, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI66932975, Length=390, Percent_Identity=28.974358974359, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=29.4270833333333, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=419, Percent_Identity=28.6396181384248, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=355, Percent_Identity=27.0422535211268, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17136978, Length=370, Percent_Identity=29.7297297297297, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24638841, Length=370, Percent_Identity=29.7297297297297, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44758; Mature: 44758

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS01070 NUCLEASE_NON_SPEC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKRNTISVEQAREVLCNQITHLPVERKIVTEALNQVLQEPVFAPFPAPYFRRSGYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCE
AITEADDGNYPIRLHVVAEVPCGKTYDKPLNPGETVRIMTGAKVPDNAAKIIMLEQSRNA
EEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCC
DKENEIILINTQKSSNITEIGAEFAKGDLLLDRGHILNAGSISLLSSFGIHEVQVIKKPK
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCEECCCCHHHHHHCCCCEEEEECCCC
VAILSTGSELISAGNPLPDGKIYNSNQPLLENLLKVHHAEICVAEQLPDNYEDTKKRLLE
EEEEECCHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHEEEHHHCCCCHHHHHHHHHH
LTEIADLIITTGGVSVGDYDFMADIAKQEAELLFNKIQMRPGSPTTGMWLNQTLIIALSG
HHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECC
NPGACFTGFYLLVEPVLATLMGKDTTATTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGE
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCEEEEECCCCC
YLVDLVGSDMSSALGNLHLTTCLFKIPRGQVGKFKGEEVEAWLLSSK
EEEEECCCCHHHHHCCCEEEHHHEECCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MIEKRNTISVEQAREVLCNQITHLPVERKIVTEALNQVLQEPVFAPFPAPYFRRSGYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCE
AITEADDGNYPIRLHVVAEVPCGKTYDKPLNPGETVRIMTGAKVPDNAAKIIMLEQSRNA
EEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCC
DKENEIILINTQKSSNITEIGAEFAKGDLLLDRGHILNAGSISLLSSFGIHEVQVIKKPK
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCEECCCCHHHHHHCCCCEEEEECCCC
VAILSTGSELISAGNPLPDGKIYNSNQPLLENLLKVHHAEICVAEQLPDNYEDTKKRLLE
EEEEECCHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHEEEHHHCCCCHHHHHHHHHH
LTEIADLIITTGGVSVGDYDFMADIAKQEAELLFNKIQMRPGSPTTGMWLNQTLIIALSG
HHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECC
NPGACFTGFYLLVEPVLATLMGKDTTATTKVRAKMASDYTKNNGYDRFLRGTYRLSDEGE
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHCEEEEECCCCC
YLVDLVGSDMSSALGNLHLTTCLFKIPRGQVGKFKGEEVEAWLLSSK
EEEEECCCCHHHHHCCCEEEHHHEECCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA