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The map label for this gene is htpX

Identifier: 116872363

GI number: 116872363

Start: 970855

End: 971769

Strand: Direct

Name: htpX

Synonym: lwe0945

Alternate gene names: 116872363

Gene position: 970855-971769 (Clockwise)

Preceding gene: 116872362

Following gene: 116872367

Centisome position: 34.5

GC content: 36.07

Gene sequence:

>915_bases
ATGCTATTTGAACAAATTGCAGCAAATAAACGAAAAACTGTTTTTATCGTAATTGGCTTTTTTATTTTCGTTCTAATGGT
TGGTGCTGCTATTGGTATAATTGTTTGGAATAATTATCTGAATGGGCTTATATTAGCAGCAGTGATTGGTGCATTTTATA
TTTTGATAATGGTTATGACTAGTTCTTCCGTTGTAATGGCGATGAATCGTGCGAAAAGAATCACATCAAAAGAACAAGCA
CCTGTTTTATGGGACACCGTGGAAAGTATGGCGATGGTTGCTAGTATTCCGATGCCAAAAGTATATATTATGAATGATTT
AAGTCTAAATGCTTTTTCGGCAGGTATTTCTCCTGAAAAAGGGGCAGTAGCTGTTACGCAAGGATTACTAGATAATTTAG
AACGCTATGAATTAGAGGGCGTTATTGCTCACGAAGTTTCTCATATACGCAACTATGATATCCGTTTGTCAACAATCTCC
ATTGCGCTAGTAGCCGTAATTGCTATTCTAAGTGATTTAGCTATGCGAATGATTTTCTGGGGAAGTGTAACAGGTAGTAG
AAATAATCGGAAAAATGATAATAACAGTGGAGGCGGCGCTCAGTTAATAATATATATTGTAGCACTTGTCTTTGTTGTTT
TAGCACCTATTATTGCTACTGCAATCCAGTTCGCTTTATCAAGAAATAGAGAATATTTAGCGGATGCAAGCGCAATTGAA
TTGACACGGAATCCAGATGGACTGATCCAAGCATTACAAAAAGTTAGCGGTGATACGAAAAAAATGAAAGAAGTAAGTGC
TTCTAGTGAATCCATTTACTTCTCATCACCTTTGAAGTCAAAAAAAGATAAACCAGGTATTTTTGATTCCCATCCGCCTA
TTAGTTCAAGAATCGAGCGTTTGGAAAATATGTAA

Upstream 100 bases:

>100_bases
AAACTGCATAACTTTACTGAACGTGAAATGCTCTCTATTCCAGAAGTAGAACGTGTTGCACCAAAAGTAGAGTTTTAAGC
CATGAAGGAGAGCGGAAATC

Downstream 100 bases:

>100_bases
AAAAAAAGTAGCAACCTAGGAATGGGTTGCTACTTTTTTTATAATGTGCCGATATATTTCCAGTGAGGTTGTCCTTCTGG
GGCGTCAATTAATTCTACAA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLFEQIAANKRKTVFIVIGFFIFVLMVGAAIGIIVWNNYLNGLILAAVIGAFYILIMVMTSSSVVMAMNRAKRITSKEQA
PVLWDTVESMAMVASIPMPKVYIMNDLSLNAFSAGISPEKGAVAVTQGLLDNLERYELEGVIAHEVSHIRNYDIRLSTIS
IALVAVIAILSDLAMRMIFWGSVTGSRNNRKNDNNSGGGAQLIIYIVALVFVVLAPIIATAIQFALSRNREYLADASAIE
LTRNPDGLIQALQKVSGDTKKMKEVSASSESIYFSSPLKSKKDKPGIFDSHPPISSRIERLENM

Sequences:

>Translated_304_residues
MLFEQIAANKRKTVFIVIGFFIFVLMVGAAIGIIVWNNYLNGLILAAVIGAFYILIMVMTSSSVVMAMNRAKRITSKEQA
PVLWDTVESMAMVASIPMPKVYIMNDLSLNAFSAGISPEKGAVAVTQGLLDNLERYELEGVIAHEVSHIRNYDIRLSTIS
IALVAVIAILSDLAMRMIFWGSVTGSRNNRKNDNNSGGGAQLIIYIVALVFVVLAPIIATAIQFALSRNREYLADASAIE
LTRNPDGLIQALQKVSGDTKKMKEVSASSESIYFSSPLKSKKDKPGIFDSHPPISSRIERLENM
>Mature_304_residues
MLFEQIAANKRKTVFIVIGFFIFVLMVGAAIGIIVWNNYLNGLILAAVIGAFYILIMVMTSSSVVMAMNRAKRITSKEQA
PVLWDTVESMAMVASIPMPKVYIMNDLSLNAFSAGISPEKGAVAVTQGLLDNLERYELEGVIAHEVSHIRNYDIRLSTIS
IALVAVIAILSDLAMRMIFWGSVTGSRNNRKNDNNSGGGAQLIIYIVALVFVVLAPIIATAIQFALSRNREYLADASAIE
LTRNPDGLIQALQKVSGDTKKMKEVSASSESIYFSSPLKSKKDKPGIFDSHPPISSRIERLENM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=226, Percent_Identity=32.7433628318584, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_LISW6 (A0AH81)

Other databases:

- EMBL:   AM263198
- RefSeq:   YP_849144.1
- ProteinModelPortal:   A0AH81
- STRING:   A0AH81
- MEROPS:   M48.004
- GeneID:   4463750
- GenomeReviews:   AM263198_GR
- KEGG:   lwe:lwe0945
- NMPDR:   fig|386043.6.peg.919
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   GLYTHIA
- PhylomeDB:   A0AH81
- ProtClustDB:   PRK04897
- BioCyc:   LWEL386043:LWE0945-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 33262; Mature: 33262

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 145-145

Signals:

None

Transmembrane regions:

HASH(0x19e02b98)-; HASH(0x19d573a0)-; HASH(0x184d98c4)-; HASH(0x187b956c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFEQIAANKRKTVFIVIGFFIFVLMVGAAIGIIVWNNYLNGLILAAVIGAFYILIMVMT
CCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSSVVMAMNRAKRITSKEQAPVLWDTVESMAMVASIPMPKVYIMNDLSLNAFSAGISPEK
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCC
GAVAVTQGLLDNLERYELEGVIAHEVSHIRNYDIRLSTISIALVAVIAILSDLAMRMIFW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
GSVTGSRNNRKNDNNSGGGAQLIIYIVALVFVVLAPIIATAIQFALSRNREYLADASAIE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHEE
LTRNPDGLIQALQKVSGDTKKMKEVSASSESIYFSSPLKSKKDKPGIFDSHPPISSRIER
ECCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
LENM
HHCH
>Mature Secondary Structure
MLFEQIAANKRKTVFIVIGFFIFVLMVGAAIGIIVWNNYLNGLILAAVIGAFYILIMVMT
CCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSSVVMAMNRAKRITSKEQAPVLWDTVESMAMVASIPMPKVYIMNDLSLNAFSAGISPEK
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCC
GAVAVTQGLLDNLERYELEGVIAHEVSHIRNYDIRLSTISIALVAVIAILSDLAMRMIFW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
GSVTGSRNNRKNDNNSGGGAQLIIYIVALVFVVLAPIIATAIQFALSRNREYLADASAIE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHEE
LTRNPDGLIQALQKVSGDTKKMKEVSASSESIYFSSPLKSKKDKPGIFDSHPPISSRIER
ECCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
LENM
HHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA