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The map label for this gene is comEC [H]

Identifier: 116872341

GI number: 116872341

Start: 952148

End: 953278

Strand: Direct

Name: comEC [H]

Synonym: lwe0923

Alternate gene names: 116872341

Gene position: 952148-953278 (Clockwise)

Preceding gene: 116872340

Following gene: 116872342

Centisome position: 33.83

GC content: 36.16

Gene sequence:

>1131_bases
ATGATAAAGAAATTAGTAATTGGTATAAGTTTAATCGCAATATTCTTAAGTGGTTGTAGTATGTCAGAACCATCTTCAAA
AACATCCACTATAACCGAAAAAACATTAAATGGTGCAAGTTTTACTTTTTTTGACGTTGGTCAAGGAGATAGCACGCTTA
TTCAAGCAAAAGATGGCACAACAGTGTTAATTGACACCGGACGACAAGACGATGACCGGATTTTGAGTTATTTAAAAGAA
GCAAAGATAAAGAAGATAGATTTGCTTTTACTGACACACCCGCATGCGGACCATATTGGAAATGCAGACAAAGTGATTGC
TACATATAAACCGAAAGAAATTTGGATGGATGGCTTAACTTTTTCCAGTAGTATTTATGAAAAAGTAATTGATGCCGCAT
TAGCTTCAGATGCGAAATATAAAGAACCAAGACGTGGTGACAAAGCAACTTTCGGACCTTTTAATTTAGAAGTTTTAAGC
CCAGATAAATTGGAAAATGATGCCAATAATGATTCTATCGCAGTAAAAATAACCTATAAAGATATTTCTGCCATTTTTAC
TGGGGACGCAGAAAAAGGACGCGAAAAAGAAGTAGTAGATAGTGGCGCCAATCTAGAAGCAGATATTTTGGACTTAGGAC
ACCATGGTTCTTCTACATCGAATCAACCATTTTTTCTTGATAAAATAAAACCACAAGTGGCTGTGTATTCTGCAGAAATG
GCAAATAGTTACGGTCATCCGCATGTAGAGGTATTGGAATGGTTGAAAGAACGCGATATTAAAACCTATGGAACAGATGT
TAACGGAACAGTTATTATTGAAACGGATGGCGAGAAACTACATGTTCAAACCGAAAAATCAGGTATACCAAAAGCAGGTA
GCAGCTACAATAAAGAAAATAGCACACAAAAAACAGAAGATGCAACCTCCGAAGAATTACCAGAAAGTATTAATTTGAAC
GCTGCCACAAGTGAAGAATTACAATTATTACCACTCATTGGACCAGCTCTTGCAGAAAAAATTATTGCAGAGCGTCCATA
TCAATCCATAGATGAATTAAAAAAAATTAACGGCATTGGCGATGGTATCGTTCGTCAAATAAAAGAACAAGGCATTGCCG
TAACGAAGTAG

Upstream 100 bases:

>100_bases
CCGCGTGTAATCGTTATGATTCCATGCGGTTTTTATTTTAAAAAAGCCTTTACTGTTTCTTGTTCCTTTGCTATTCTACT
TAGAGAGCAGGAGGAGTAAC

Downstream 100 bases:

>100_bases
GTGATTAGGGTGAAAAAGGCAATTTTAGATCGTGTGGAAGATGGAAAAGCAGTTTTTTTGTTAGAACCTGACCAAACAGA
ATGGCAAGTAGACAAAGAAA

Product: putative secreted lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MIKKLVIGISLIAIFLSGCSMSEPSSKTSTITEKTLNGASFTFFDVGQGDSTLIQAKDGTTVLIDTGRQDDDRILSYLKE
AKIKKIDLLLLTHPHADHIGNADKVIATYKPKEIWMDGLTFSSSIYEKVIDAALASDAKYKEPRRGDKATFGPFNLEVLS
PDKLENDANNDSIAVKITYKDISAIFTGDAEKGREKEVVDSGANLEADILDLGHHGSSTSNQPFFLDKIKPQVAVYSAEM
ANSYGHPHVEVLEWLKERDIKTYGTDVNGTVIIETDGEKLHVQTEKSGIPKAGSSYNKENSTQKTEDATSEELPESINLN
AATSEELQLLPLIGPALAEKIIAERPYQSIDELKKINGIGDGIVRQIKEQGIAVTK

Sequences:

>Translated_376_residues
MIKKLVIGISLIAIFLSGCSMSEPSSKTSTITEKTLNGASFTFFDVGQGDSTLIQAKDGTTVLIDTGRQDDDRILSYLKE
AKIKKIDLLLLTHPHADHIGNADKVIATYKPKEIWMDGLTFSSSIYEKVIDAALASDAKYKEPRRGDKATFGPFNLEVLS
PDKLENDANNDSIAVKITYKDISAIFTGDAEKGREKEVVDSGANLEADILDLGHHGSSTSNQPFFLDKIKPQVAVYSAEM
ANSYGHPHVEVLEWLKERDIKTYGTDVNGTVIIETDGEKLHVQTEKSGIPKAGSSYNKENSTQKTEDATSEELPESINLN
AATSEELQLLPLIGPALAEKIIAERPYQSIDELKKINGIGDGIVRQIKEQGIAVTK
>Mature_376_residues
MIKKLVIGISLIAIFLSGCSMSEPSSKTSTITEKTLNGASFTFFDVGQGDSTLIQAKDGTTVLIDTGRQDDDRILSYLKE
AKIKKIDLLLLTHPHADHIGNADKVIATYKPKEIWMDGLTFSSSIYEKVIDAALASDAKYKEPRRGDKATFGPFNLEVLS
PDKLENDANNDSIAVKITYKDISAIFTGDAEKGREKEVVDSGANLEADILDLGHHGSSTSNQPFFLDKIKPQVAVYSAEM
ANSYGHPHVEVLEWLKERDIKTYGTDVNGTVIIETDGEKLHVQTEKSGIPKAGSSYNKENSTQKTEDATSEELPESINLN
AATSEELQLLPLIGPALAEKIIAERPYQSIDELKKINGIGDGIVRQIKEQGIAVTK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 41056; Mature: 41056

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLVIGISLIAIFLSGCSMSEPSSKTSTITEKTLNGASFTFFDVGQGDSTLIQAKDGT
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCC
TVLIDTGRQDDDRILSYLKEAKIKKIDLLLLTHPHADHIGNADKVIATYKPKEIWMDGLT
EEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCCCCEEEEECCHHHHCCCCC
FSSSIYEKVIDAALASDAKYKEPRRGDKATFGPFNLEVLSPDKLENDANNDSIAVKITYK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCCEEEEEEEEE
DISAIFTGDAEKGREKEVVDSGANLEADILDLGHHGSSTSNQPFFLDKIKPQVAVYSAEM
CEEEEEECCCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCEEEEHHH
ANSYGHPHVEVLEWLKERDIKTYGTDVNGTVIIETDGEKLHVQTEKSGIPKAGSSYNKEN
HHCCCCCHHHHHHHHHHCCCEECCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCC
STQKTEDATSEELPESINLNAATSEELQLLPLIGPALAEKIIAERPYQSIDELKKINGIG
CCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCCC
DGIVRQIKEQGIAVTK
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIKKLVIGISLIAIFLSGCSMSEPSSKTSTITEKTLNGASFTFFDVGQGDSTLIQAKDGT
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCC
TVLIDTGRQDDDRILSYLKEAKIKKIDLLLLTHPHADHIGNADKVIATYKPKEIWMDGLT
EEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCCCCEEEEECCHHHHCCCCC
FSSSIYEKVIDAALASDAKYKEPRRGDKATFGPFNLEVLSPDKLENDANNDSIAVKITYK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCCEEEEEEEEE
DISAIFTGDAEKGREKEVVDSGANLEADILDLGHHGSSTSNQPFFLDKIKPQVAVYSAEM
CEEEEEECCCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCEEEEHHH
ANSYGHPHVEVLEWLKERDIKTYGTDVNGTVIIETDGEKLHVQTEKSGIPKAGSSYNKEN
HHCCCCCHHHHHHHHHHCCCEECCCCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCC
STQKTEDATSEELPESINLNAATSEELQLLPLIGPALAEKIIAERPYQSIDELKKINGIG
CCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHCCCC
DGIVRQIKEQGIAVTK
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]