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The map label for this gene is polC [H]

Identifier: 116690004

GI number: 116690004

Start: 2199909

End: 2200547

Strand: Direct

Name: polC [H]

Synonym: Bcen2424_1983

Alternate gene names: 116690004

Gene position: 2199909-2200547 (Clockwise)

Preceding gene: 116690002

Following gene: 116690006

Centisome position: 63.14

GC content: 63.85

Gene sequence:

>639_bases
ATGACGCCCCCGAATTCAACCATGCAAACCGTCGCGGTACTGGACTTCGAAACAACCGGCCTGTCGCCGAATCTGGGCGA
CCGTGCAACCGAAATTGCCGTCATCCTGCTGCGCAACGGGCAGGTCGTCGACCGTTTCCAGAGTTTGATGAATGCCGGCC
GACGCATCCCGTCCGATGTCGTTGCGCTCACCGGCATCACGAACGACATGATCGCGACGGCGCCGCCGGCGTCCGAAGTC
ATGAAGGAAGCGGCGGCGTTCGTCGGCAAGCATGCGGTCGTGGCCCACAACGCCGGTTTCGACAAACGCTTCTGGCAGTC
GGAACTCGGGATGCTCGGCATGTCGGCCGACCATGCGTTTGCGTGCACGATGCTGGTGGCGAGACGAATCTACCCGGACG
CGCGGAGTCACCGCCTGTCGAGCCTCGCCGAGATGCTGCGGCTGCCGCAAACGGGTCGTGCGCACCGCGCGATGGTCGAT
GCGGAGATGGCCGGCCATCTGTGGTGCCGGTTGCAGCAGGATATTTCGCGGACTTACGGGCTGGATCGCATCGATCACGC
GCTGATGTCGCGTGTTCAGGCGACGACCAAGGCGAAGGTGCCGATGTACTTGCGTTCGCTCGTGCGCGCGCACGCGTGA

Upstream 100 bases:

>100_bases
CGTCAATCGGTAGCCGGCCCGCTCGCTGCTCACCGCTAGACGAATCCGCCGTTCACACGCCTGAAGATGCTACCCTCTCG
GCCACACTCGACACCCTCTG

Downstream 100 bases:

>100_bases
GCAATTCACGCACTGTGTAAACGCAAAACGGCTTGGCAACATCCAAGCCGTTTCTTGTACCCCGGCAGCGTCAGGCACGC
TGCTTCATCAGCCCGGCCAG

Product: DNA polymerase III, epsilon subunit

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTPPNSTMQTVAVLDFETTGLSPNLGDRATEIAVILLRNGQVVDRFQSLMNAGRRIPSDVVALTGITNDMIATAPPASEV
MKEAAAFVGKHAVVAHNAGFDKRFWQSELGMLGMSADHAFACTMLVARRIYPDARSHRLSSLAEMLRLPQTGRAHRAMVD
AEMAGHLWCRLQQDISRTYGLDRIDHALMSRVQATTKAKVPMYLRSLVRAHA

Sequences:

>Translated_212_residues
MTPPNSTMQTVAVLDFETTGLSPNLGDRATEIAVILLRNGQVVDRFQSLMNAGRRIPSDVVALTGITNDMIATAPPASEV
MKEAAAFVGKHAVVAHNAGFDKRFWQSELGMLGMSADHAFACTMLVARRIYPDARSHRLSSLAEMLRLPQTGRAHRAMVD
AEMAGHLWCRLQQDISRTYGLDRIDHALMSRVQATTKAKVPMYLRSLVRAHA
>Mature_211_residues
TPPNSTMQTVAVLDFETTGLSPNLGDRATEIAVILLRNGQVVDRFQSLMNAGRRIPSDVVALTGITNDMIATAPPASEVM
KEAAAFVGKHAVVAHNAGFDKRFWQSELGMLGMSADHAFACTMLVARRIYPDARSHRLSSLAEMLRLPQTGRAHRAMVDA
EMAGHLWCRLQQDISRTYGLDRIDHALMSRVQATTKAKVPMYLRSLVRAHA

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 23297; Mature: 23166

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPNSTMQTVAVLDFETTGLSPNLGDRATEIAVILLRNGQVVDRFQSLMNAGRRIPSDV
CCCCCCCHHEEEEEEEECCCCCCCCCCHHHHEEEEEECCCHHHHHHHHHHHHCCCCCHHH
VALTGITNDMIATAPPASEVMKEAAAFVGKHAVVAHNAGFDKRFWQSELGMLGMSADHAF
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHHCCCCCCHHH
ACTMLVARRIYPDARSHRLSSLAEMLRLPQTGRAHRAMVDAEMAGHLWCRLQQDISRTYG
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDRIDHALMSRVQATTKAKVPMYLRSLVRAHA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TPPNSTMQTVAVLDFETTGLSPNLGDRATEIAVILLRNGQVVDRFQSLMNAGRRIPSDV
CCCCCCHHEEEEEEEECCCCCCCCCCHHHHEEEEEECCCHHHHHHHHHHHHCCCCCHHH
VALTGITNDMIATAPPASEVMKEAAAFVGKHAVVAHNAGFDKRFWQSELGMLGMSADHAF
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHEEECCCCCHHHHHHHHHHCCCCCCHHH
ACTMLVARRIYPDARSHRLSSLAEMLRLPQTGRAHRAMVDAEMAGHLWCRLQQDISRTYG
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDRIDHALMSRVQATTKAKVPMYLRSLVRAHA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]