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The map label for this gene is hdaH [H]

Identifier: 116689952

GI number: 116689952

Start: 2147622

End: 2148731

Strand: Direct

Name: hdaH [H]

Synonym: Bcen2424_1931

Alternate gene names: 116689952

Gene position: 2147622-2148731 (Clockwise)

Preceding gene: 116689951

Following gene: 116689953

Centisome position: 61.64

GC content: 69.01

Gene sequence:

>1110_bases
ATGAATCGCACTGCCTTCTTCACCGACGAACGCACTTTCTGGCATACCGGCGGCACGCACGCGCTGTTCTTCCCAGTCGG
AGGCTGGGTCCAGCCGCCGTCGAGCGCGGGCTACGCGGAATCGCCCGATTCGAAACGCCGCTTCCTGTCGCTCGTGCAGG
CGTCGGGCCTGGCCGCGCAACTCGACCTGCGTGGCGCCGAGCCCGCGACGACGGCCGACCTGCTGCGCATTCATCCGGCG
CACTATCTCGATGCATTTCGCGCGCTGAGCGACGCGAACGGTGGCGACCTCGGCGATCTCGCGCCATTCGGCAAGGGCAG
CTACGAGATCGCCGCGCTGTCGGCCGGTCTCGCGATCGTGGCGGTCGATGCGGTCGTCGGCGAGCGCGCGGCGAATGCGT
TCTCGCTGTCGCGGCCGCCCGGCCATCACTGCCTGCGCGACCGCCCGATGGGCTTCTGCATGCTCGCGAACATCCCGGTC
GCGATCGAGGCCGCGCGCGCGAAGCACGGCATCGAGCGCGTCGCGGTGATCGACTGGGACGTGCATCACGGCAACGGCAC
GCAGTCGATCTACTACGACGATCCCGATACGCTGACGATCTCGCTGCACCAGGATCGCTGCTTCCCGCCCGGCTACAGCG
GCGCGGACGATCGCGGCGAAGGCGCGGGCATCGGCGCGAACCTGAACGTGCCGCTGCTCGCGGGCAGCGGCGACGACGCG
TACCGGTATGCGTTCGAGCGAATCGTGCTGCCGGCGCTCGCGCGTTTCCGCCCCGAGCTGATCGTCATCGCGAGCGGCCT
CGATGCGAGCGCGGTCGATCCGCTCGCGCGCATGCAGTTGCATACCGACAGCTACCGGTTCATGACGCGCGCGGTAAAGG
AGGCCGCGCAGCGCCATTGCGGCGGGCGGCTCGTGATCGTTCACGAAGGCGGCTATTCGGAGGCGTACGTGCCGTTCTGC
GGGCTCGCGATCGTCGAGGAACTGGCCGGCATCCGCACCGCGGTCACCGATCCGATGCTCGACCTGGCGATCGCGCAGCA
GCCGGGCGCGCGGTTCGTTGCGTTCCAGCGCGCACTGCTCGACGAACTGGCCGCGTCGTTCGGGTTGTAA

Upstream 100 bases:

>100_bases
CCGCGACGGCCGTCGCGATCGTGTCGTTCGCCGCGCTGCGCCACATCGATCGCCGCGCGCGCTCTTCCGTTTCCTCCCAA
CCGTGACAGGTCACGCATCC

Downstream 100 bases:

>100_bases
CGCGCGGGAACGGACGTGACGGGGCCGGCCCGCGCCGGCCCTTGCGCGATCCGTGCGGATGGGGTTTCCTGTGTCTTTAC
CCCTGTTCCGGCACGAGGCC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQLDLRGAEPATTADLLRIHPA
HYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIVAVDAVVGERAANAFSLSRPPGHHCLRDRPMGFCMLANIPV
AIEAARAKHGIERVAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGIGANLNVPLLAGSGDDA
YRYAFERIVLPALARFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGIRTAVTDPMLDLAIAQQPGARFVAFQRALLDELAASFGL

Sequences:

>Translated_369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQLDLRGAEPATTADLLRIHPA
HYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIVAVDAVVGERAANAFSLSRPPGHHCLRDRPMGFCMLANIPV
AIEAARAKHGIERVAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGIGANLNVPLLAGSGDDA
YRYAFERIVLPALARFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGIRTAVTDPMLDLAIAQQPGARFVAFQRALLDELAASFGL
>Mature_369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQLDLRGAEPATTADLLRIHPA
HYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIVAVDAVVGERAANAFSLSRPPGHHCLRDRPMGFCMLANIPV
AIEAARAKHGIERVAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGIGANLNVPLLAGSGDDA
YRYAFERIVLPALARFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGIRTAVTDPMLDLAIAQQPGARFVAFQRALLDELAASFGL

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=291, Percent_Identity=34.3642611683849, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI20070354, Length=284, Percent_Identity=33.4507042253521, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI153085395, Length=259, Percent_Identity=32.8185328185328, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI169234807, Length=233, Percent_Identity=33.9055793991416, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI148539870, Length=232, Percent_Identity=34.051724137931, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI30795202, Length=259, Percent_Identity=29.7297297297297, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI30795204, Length=259, Percent_Identity=29.7297297297297, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI17158039, Length=259, Percent_Identity=29.7297297297297, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI62750349, Length=231, Percent_Identity=32.4675324675325, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI62750347, Length=231, Percent_Identity=32.4675324675325, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI226529806, Length=284, Percent_Identity=30.6338028169014, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI8923769, Length=251, Percent_Identity=27.0916334661355, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI293336691, Length=267, Percent_Identity=25.0936329588015, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI13128860, Length=254, Percent_Identity=25.1968503937008, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI13128862, Length=255, Percent_Identity=26.2745098039216, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=28.2511210762332, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI262073088, Length=182, Percent_Identity=29.1208791208791, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=31.7152103559871, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=31.7152103559871, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=31.7152103559871, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI193209491, Length=239, Percent_Identity=33.8912133891213, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=313, Percent_Identity=28.7539936102236, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25154020, Length=286, Percent_Identity=26.5734265734266, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17561978, Length=297, Percent_Identity=27.6094276094276, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25154022, Length=286, Percent_Identity=25.8741258741259, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17537347, Length=256, Percent_Identity=28.90625, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534739, Length=226, Percent_Identity=29.646017699115, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=318, Percent_Identity=31.7610062893082, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321244, Length=274, Percent_Identity=29.5620437956204, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323999, Length=288, Percent_Identity=28.4722222222222, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6325141, Length=312, Percent_Identity=28.2051282051282, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325325, Length=199, Percent_Identity=24.1206030150754, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281360899, Length=337, Percent_Identity=32.6409495548961, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24642146, Length=337, Percent_Identity=32.6409495548961, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24642144, Length=337, Percent_Identity=32.6409495548961, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24642142, Length=337, Percent_Identity=32.6409495548961, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24641720, Length=246, Percent_Identity=34.9593495934959, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281360799, Length=246, Percent_Identity=34.9593495934959, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281360801, Length=246, Percent_Identity=34.9593495934959, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24657891, Length=254, Percent_Identity=28.3464566929134, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24644244, Length=273, Percent_Identity=26.3736263736264, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39497; Mature: 39497

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQ
CCCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDLRGAEPATTADLLRIHPAHYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIV
EECCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEE
AVDAVVGERAANAFSLSRPPGHHCLRDRPMGFCMLANIPVAIEAARAKHGIERVAVIDWD
EHHHHHHHHHCCCEECCCCCCCHHHHCCCCCEEEEECCCEEEEHHHHHCCCCEEEEEEEE
VHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGIGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALARFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCHHHHHEECCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGIRTAVTDPMLDLAIAQQPGARFVAFQRALL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHH
DELAASFGL
HHHHHHHCC
>Mature Secondary Structure
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAQ
CCCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDLRGAEPATTADLLRIHPAHYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIV
EECCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEE
AVDAVVGERAANAFSLSRPPGHHCLRDRPMGFCMLANIPVAIEAARAKHGIERVAVIDWD
EHHHHHHHHHCCCEECCCCCCCHHHHCCCCCEEEEECCCEEEEHHHHHCCCCEEEEEEEE
VHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYSGADDRGEGAGIGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALARFRPELIVIASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCHHHHHEECCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGIRTAVTDPMLDLAIAQQPGARFVAFQRALL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHH
DELAASFGL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA