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The map label for this gene is phbA [H]

Identifier: 116689811

GI number: 116689811

Start: 1986637

End: 1987818

Strand: Reverse

Name: phbA [H]

Synonym: Bcen2424_1790

Alternate gene names: 116689811

Gene position: 1987818-1986637 (Counterclockwise)

Preceding gene: 116689812

Following gene: 116689810

Centisome position: 57.06

GC content: 70.14

Gene sequence:

>1182_bases
ATGACGGATGTAGTGATCGTATCGGCCGCGCGGACCGCGGTCGGCAAATTCGGCGGCTCGCTCGCGAAGATTGCGGCGCC
CGAACTGGGCGCGACGGTGATCCGCGCGGTGCTGGAGCGTGCGGGCGTGAAGCCCGAGCAGGTCAGCGAAGTGATCATGG
GCCAGGTGCTGACGGCCGGCTCCGGGCAGAACCCGGCGCGGCAGTCGCTGATCAAGGCGGGGCTGCCGACGGCCGTGCCG
GGGATGACGATCAACAAGGTGTGCGGCTCGGGCCTGAAGGCCGTGATGCTGGCGGCGAACGCGATCATCGCGGGCGACGC
GGAGATCGTGGTCGCAGGCGGCCAGGAGAACATGAGCGCGTCGCCGCACGTGCTGCCGGGCTCGCGCGACGGCTTCCGGA
TGGGCGACGCGAAGCTGGTCGACACGATGATCGTCGACGGCCTGTGGGACGTGTACAACCAGTACCACATGGGCATCACG
GCGGAGAACGTCGCGAAGGAATACGGGATCACGCGCGAAGAGCAGGACGCGTTTGCGGCGCTGTCGCAGAACAAGGCGGA
AGCCGCGCAGAAGGCCGGCCGTTTCAATGACGAGATCGTGCCGGTGTCGATCCCGCAACGCAAGGGCGAGCCGCTGCAGT
TCGCGACCGACGAGTTCGTGCGTCACGGCGTGACGGCGGAATCGCTGGCGGGCCTGAAGCCGGCGTTCTCGAAGGACGGC
TCGGTGACGGCGGCGAACGCGTCGGGGCTGAACGACGGCGCGGCGGCGGTGCTGGTGATGTCGGCGCAGAAGGCGGCGGC
GCTGGGCCTGACGCCGCTGGCGCGGATCAAGGCGTACGCGAACGCGGGCGTGGACCCGAGCGTGATGGGCATGGGCCCGG
TGCCGGCGTCGCGCCGTGCGCTGGAGCGCGCGGGCTGGACGCCGGGCGACCTGGACCTGATGGAAATCAACGAGGCGTTC
GCGGCGCAGGCGCTGGCGGTGCACAAGCAGATGGGCTGGGACACGTCGAAGGTGAACGTGAACGGCGGGGCGATCGCGAT
CGGCCACCCGATCGGCGCGTCGGGCTGCCGGATTCTGGTGACGCTGCTGCACGAGATGGCCAAGCGCGACGCGAAGCGCG
GGCTGGCGTCGCTGTGCATCGGCGGCGGGATGGGCGTCGCGCTCGCGGTCGAGCGTCCGTAA

Upstream 100 bases:

>100_bases
ACGAAAACCGGACAGCGGCGCACGCTGTCCGGTGCACCGCAGTTTTTTTAACAGGGCCGGTAACGATGCGCCGTGTCGTG
CGGGCCTGGAGGAAAGGGAA

Downstream 100 bases:

>100_bases
CCGGCCGTCCGTAACCGGCCGTTCGCCATCGGCGAACCGAATCCGTGCGTCGGCCGATTGCGGCTTCGGCCGGCGTCACG
TGAAGTCAGAGGGGGCTCCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVP
GMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRALERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERP

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVP
GMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRALERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERP
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVPG
MTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITA
ENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDGS
VTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRALERAGWTPGDLDLMEINEAFA
AQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.2659846547315, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=45.0381679389313, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.6153846153846, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=43.21608040201, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.3679245283019, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=31.8987341772152, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=62.2448979591837, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.8142493638677, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.5445544554455, Blast_Score=321, Evalue=6e-89,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.8571428571429, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=34.2298288508557, Blast_Score=198, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=46.4102564102564, Blast_Score=332, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.3772609819121, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=41.9191919191919, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=32.3979591836735, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.7757009345794, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=42.0654911838791, Blast_Score=288, Evalue=8e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=40.1002506265664, Blast_Score=236, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.3979591836735, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.3104325699746, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.3846153846154, Blast_Score=314, Evalue=6e-86,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.2941176470588, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40406; Mature: 40275

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPTAVPGMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
SPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRA
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCEECCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMAKRDAKRGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPTAVPGMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
SPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFNDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRA
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCEECCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMAKRDAKRGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]