Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 116689576

GI number: 116689576

Start: 1720344

End: 1721414

Strand: Reverse

Name: pyrD [H]

Synonym: Bcen2424_1554

Alternate gene names: 116689576

Gene position: 1721414-1720344 (Counterclockwise)

Preceding gene: 116689577

Following gene: 116689575

Centisome position: 49.41

GC content: 68.63

Gene sequence:

>1071_bases
TTGTCATTCATTCCGGCTGTCCGCCCAACTCCCGTGTTCAGTTCCCTCTACCCGCTGGCCCGCGCATCCCTGTTCAAAAT
GGATGCGGAAGACGCTCACCACCTTACGTTGCGCGCGCTCGGCGCGGCCGGCCGCACGGGCCTCGCCTGCGCGCTGTCGG
CCCGCGTGCCCGACGCGCCGCGCACCGTGATGGGGCTCACGTTCCGCAACCCGGTCGGCCTCGCGGCCGGCCTCGACAAG
GACGGCGCGGCCATCGACGGCCTCGCGGCGCTCGGCTTCGGCTTCATCGAGGTCGGCACGGTCACGCCGCGCCCGCAACC
CGGCAACCCGCGCCCGCGGATGTTCCGGCTGCCGCAGGCCGAGGCGCTGATCAACCGGATGGGCTTCAACAACCACGGCG
TCGACCAGTTCGTGAAGAACGTCCAGGCCGCCCGCTATCGCGGCATCCTCGGCCTGAACATCGGCAAGAACGCCGACACG
CCGATCGAGCGCGCCGCCGAGGATTACCTGTACTGCCTCGAGCGCGTGTACCCGTTCGCGAGCTACGTGACGATCAACAT
CTCGTCGCCGAACACGAAGAACCTGCGCCAGTTGCAGGGCGCGGGCGAGCTCGACGCACTGCTCGCCGCGCTGAAGGACA
AGCAGCAGCGCCTGGCCGACCTGCACGGCAAGCTCGTGCCGCTCGCGCTGAAGATCGCGCCCGATCTCGACGACGAACAG
GTCAAGGAAATCGGCGACACGCTGCTGCGCCACAAGATCGAAGCGGTAATCGCCACCAATACGACGCTGTCGCGCGCGGC
CGTCCAGGGCCTGCCGCATGCGGACGAAGCCGGCGGCCTGTCGGGCCGCCCGGTGTTCGACGCGTCGAACGAAGTGATCC
GCAAGCTGCACGCGGAAGTCGGCAACGACGTGCCGATCATCGGCGTCGGCGGCATTTTCTCGGGCGAGGACGCCCACGCG
AAGCTGGCAGCCGGCGCGGCGCTCGTCCAGCTCTATACCGGCTTCATCTATCGCGGCCCGGCACTCGTGTCCGAATGCGT
GAAGGCGATCGCCCGCGAACGCAGCGCGTAA

Upstream 100 bases:

>100_bases
CGCCCTTGCCGGGCGGGCATTCCGGGTCGGGCTGACGCGCGCCGCGGCGGCTACGAAGCAAAGCACGCCCGTGCCGCGCA
ACTCCCGGTAAAATAGCGGG

Downstream 100 bases:

>100_bases
TATAGTCATAAACAAACTGTATTTAATGATTGATAGCGTTTTTGCTATCATCGGCTTCACGATCAGAATCATTGACCCGG
ACAGGGCAAGGACACACACG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSFIPAVRPTPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDK
DGAAIDGLAALGFGFIEVGTVTPRPQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADT
PIERAAEDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGNDVPIIGVGGIFSGEDAHA
KLAAGAALVQLYTGFIYRGPALVSECVKAIARERSA

Sequences:

>Translated_356_residues
MSFIPAVRPTPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDK
DGAAIDGLAALGFGFIEVGTVTPRPQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADT
PIERAAEDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGNDVPIIGVGGIFSGEDAHA
KLAAGAALVQLYTGFIYRGPALVSECVKAIARERSA
>Mature_355_residues
SFIPAVRPTPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDKD
GAAIDGLAALGFGFIEVGTVTPRPQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTP
IERAAEDYLYCLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQV
KEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGNDVPIIGVGGIFSGEDAHAK
LAAGAALVQLYTGFIYRGPALVSECVKAIARERSA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=44.3452380952381, Blast_Score=254, Evalue=7e-68,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=56.2874251497006, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=42.0245398773006, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI281361352, Length=296, Percent_Identity=43.9189189189189, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI17137316, Length=296, Percent_Identity=43.9189189189189, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37922; Mature: 37791

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIPAVRPTPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCC
RTVMGLTFRNPVGLAAGLDKDGAAIDGLAALGFGFIEVGTVTPRPQPGNPRPRMFRLPQA
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHH
EALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAAEDYLYCLERVYPFA
HHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE
SYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
EEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHH
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEV
HHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GNDVPIIGVGGIFSGEDAHAKLAAGAALVQLYTGFIYRGPALVSECVKAIARERSA
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFIPAVRPTPVFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAP
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCC
RTVMGLTFRNPVGLAAGLDKDGAAIDGLAALGFGFIEVGTVTPRPQPGNPRPRMFRLPQA
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHH
EALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAAEDYLYCLERVYPFA
HHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCE
SYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQ
EEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHH
VKEIGDTLLRHKIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEV
HHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GNDVPIIGVGGIFSGEDAHAKLAAGAALVQLYTGFIYRGPALVSECVKAIARERSA
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA