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The map label for this gene is fsr [H]

Identifier: 116689466

GI number: 116689466

Start: 1596884

End: 1598122

Strand: Reverse

Name: fsr [H]

Synonym: Bcen2424_1444

Alternate gene names: 116689466

Gene position: 1598122-1596884 (Counterclockwise)

Preceding gene: 116689468

Following gene: 116689463

Centisome position: 45.87

GC content: 67.15

Gene sequence:

>1239_bases
ATGGAAACCAGCCTCGACTCCGGAGCCGCCGGCGCAGCCGCCGCCCAGCCGTCCGCATCGCCCGTCGCCCGCACCATCTA
CCCGGTGCTCGGCGCGATCAGCTTCTCGCACATGCTCAACGACATGATCCAGTCGCTGATCCTCGCGATCTATCCGATGC
TCAAGAGCCAGTTCGCGCTGTCGTTCGCGCAGATCGGCCTGATCACGCTCACTTACCAGATCACCGCGTCGCTGCTGCAG
CCGCTCGTGGGCCTCTATACCGACAAGCATCCGAAGCCGTATTCGCTGCCGGTCGGCATGGGCTTCACGCTCGCGGGGCT
GCTGCTGATGTCGGCCGCGCCGAATTTCCCGATGCTGCTGGTGGCCGCCGCGCTCGTCGGCTGCGGCTCGTCGGTGTTCC
ACCCCGAATCGTCGCGGGTCGCGCGGATGGCGTCGGGCGGCCGGCACGGGCTCGCGCAGTCGGTGTTCCAGGTGGGCGGC
AATGCCGGCTCCGCGCTCGGGCCGCTGCTCGCCGCGCTCGTGATCATTCCGCACGGCCAGCACAGCATCGCTTGGTTTTC
GGCGGCCGCGCTCGTCGCGATGATCGTGCTCACGCAGATCGGCCACTGGTACAAGAAGCATCCGTCGATGAAGAAGAAGG
CCGCCTCGGCCGGCCACCCGACGCTGTCGCGCGGCCGCGTGATGGCCGCGATCGGCGTGCTGGTGCTGCTCGTGTTCTCG
AAGTACTTCTACCTCGCGAGCATCAACAGCTATTTCACGTTCTACCTGATCGACAAGTTCCACCTGTCGGTGCAGGCCGC
GCAGATCCACCTGTTCGTGTTCCTCGCGGCGGTGGCGGCCGGCACGCTGATCGGCGGGCCCGTCGGCGACCGGATCGGCC
GCAAGTACGTGATCTGGGTGTCGATCCTGGGCGTCGCGCCGTTCACGATGCTGCTGCCGTACGCGAACCTGTTCTGGACG
AGCGTGCTGACCGTGATCATCGGCGTCGTGCTGGCGTCGGCGTTCGCCGCGATCCTCGTCTATGCGACGGAGCTGATGCC
CGGCAAGGTCGGGATGGTCGCGGGCCTGTTCTTCGGCTTCGCGTTCGGCCTGGGCGGCGTCGGCGCGGCCGTGCTCGGCC
AGCTCGCCGATGCGACGAGCATCCCGTTCGTCTACAAGGTGTGCTCGTTCCTGCCGCTGATCGGCGTGCTGACGGTGTTC
CTGCCGAACCTCGAAAGCAGCCGGCGCAAAAAGGCGTGA

Upstream 100 bases:

>100_bases
TTCTCTATACGCCACATTACACTTCTTTGACGCATCAACGAATCGACAACGCGCCGATCCCCAACAGAGCGCGCCAGCCA
CCTCAACTCGTTCAGCTCAC

Downstream 100 bases:

>100_bases
CGAACGACTGGCCGCGGCGTGCGCGCCGCGGCCAGTCGAGCGGTTTGATGGGAAAAGTACGAGACGGCGGCTTCAGGCCG
CCGTCGTCGCATGCAGCGTC

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
METSLDSGAAGAAAAQPSASPVARTIYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLLQ
PLVGLYTDKHPKPYSLPVGMGFTLAGLLLMSAAPNFPMLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSVFQVGG
NAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMIVLTQIGHWYKKHPSMKKKAASAGHPTLSRGRVMAAIGVLVLLVFS
KYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTMLLPYANLFWT
SVLTVIIGVVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSIPFVYKVCSFLPLIGVLTVF
LPNLESSRRKKA

Sequences:

>Translated_412_residues
METSLDSGAAGAAAAQPSASPVARTIYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLLQ
PLVGLYTDKHPKPYSLPVGMGFTLAGLLLMSAAPNFPMLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSVFQVGG
NAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMIVLTQIGHWYKKHPSMKKKAASAGHPTLSRGRVMAAIGVLVLLVFS
KYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTMLLPYANLFWT
SVLTVIIGVVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSIPFVYKVCSFLPLIGVLTVF
LPNLESSRRKKA
>Mature_412_residues
METSLDSGAAGAAAAQPSASPVARTIYPVLGAISFSHMLNDMIQSLILAIYPMLKSQFALSFAQIGLITLTYQITASLLQ
PLVGLYTDKHPKPYSLPVGMGFTLAGLLLMSAAPNFPMLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSVFQVGG
NAGSALGPLLAALVIIPHGQHSIAWFSAAALVAMIVLTQIGHWYKKHPSMKKKAASAGHPTLSRGRVMAAIGVLVLLVFS
KYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTLIGGPVGDRIGRKYVIWVSILGVAPFTMLLPYANLFWT
SVLTVIIGVVLASAFAAILVYATELMPGKVGMVAGLFFGFAFGLGGVGAAVLGQLADATSIPFVYKVCSFLPLIGVLTVF
LPNLESSRRKKA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=404, Percent_Identity=66.3366336633663, Blast_Score=498, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43334; Mature: 43334

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]