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The map label for this gene is ptxR [H]

Identifier: 116689455

GI number: 116689455

Start: 1582141

End: 1583076

Strand: Direct

Name: ptxR [H]

Synonym: Bcen2424_1433

Alternate gene names: 116689455

Gene position: 1582141-1583076 (Clockwise)

Preceding gene: 116689453

Following gene: 116689456

Centisome position: 45.41

GC content: 71.69

Gene sequence:

>936_bases
ATGAATCAGCAAAATGTCCAGGCGCTCTGGCCGCATATCCATTCGCTGACAGTGCTGGCCGCCGCGGGCAGTTTCACGGC
TGCCGCGCAGCGGCTCGGCATCAGCAAGGCCGCGATGAGCCAGCGCATCGCCGATCTCGAAAAGGCGGCCGGCGTGCCGC
TCGTGCGCCGCACCACGCGCAGCGTGCGGCTCACCGATGCGGGCCAGACGCTCGTCGACAGCACGCGCGACGCGTTCGAG
TCGATCGGCCAGCATTTTGCGCGGGTGAAGGATCTCGCCGGCGAGCCGCGCGGGCTGCTGCGCGTCACGGTGCCGGTCGC
GCTCGGGCGCCAGCAGGTCGTGCCGCACCTGCCCGATTTCCTGCGCCAGCATCCGGGCGTGCAGATCGAGCTCGACCTGT
CGGACCGCCTGCATTCGCTGACGCAGGAGGGCTTCGACCTCGCGATCCGCCATACGACCACCGCGCCGCAGACCCACGTC
GCGTGGAAGCTGTGCGACACGCGTTCGCTGCTGGTTGCGAGCCGCGACTATCTCGACGCGCGCGGCGCGCCGCGCCACCC
GAGCGAACTCGTCGATCACAGCTGCCTGTGCTACCTGCGCGACAACGAGCCGGCGGCATGGAGCTTCGAGCCGGACGGCC
GCCGGCGCCAGCGCGTGAGCGTGCCGGTGCGCGGCAGTTTCGCGGCGAACAACAGCGAGGCGATGCGCGAGGCCGCGCTC
GGCGGGCTCGGCATCGCGCTGCTGCCCGATTTCAGCGCGCGGCGCGATCTCGACGCCGGCCGGCTCGTCGCGCTGCTCGA
CGGCTGGCGGCCGTCGGGCGCGTTCGGCGATCACATTTTCGCGATTCGTCCGTACAGCCCGGTCGTGCCGAGCGCGGTGC
GCGCGCTGGTGCGCCACTTGCGCGAGCGGCTCGCGGGCGGCTTCTCCGGCGCGTGA

Upstream 100 bases:

>100_bases
CTGGGGATGAGGGGCAACAGCGCCTAGTCTAGGGAAACCGGCAGGGCGGGAGAAGGCCGCGAAACTTGATTCACTGTTCA
GAATTCTGAATAATCAATGG

Downstream 100 bases:

>100_bases
GCCGGCTGCCGGGTGCCGGCGGGCGCGGGGCCGTGGGCGGCCGGGCAGGCGCGGCGGCGCTGCGGTAAAATCGCGGCTTC
CTCCCGCGCCGTGTGTGGCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTRSVRLTDAGQTLVDSTRDAFE
SIGQHFARVKDLAGEPRGLLRVTVPVALGRQQVVPHLPDFLRQHPGVQIELDLSDRLHSLTQEGFDLAIRHTTTAPQTHV
AWKLCDTRSLLVASRDYLDARGAPRHPSELVDHSCLCYLRDNEPAAWSFEPDGRRRQRVSVPVRGSFAANNSEAMREAAL
GGLGIALLPDFSARRDLDAGRLVALLDGWRPSGAFGDHIFAIRPYSPVVPSAVRALVRHLRERLAGGFSGA

Sequences:

>Translated_311_residues
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTRSVRLTDAGQTLVDSTRDAFE
SIGQHFARVKDLAGEPRGLLRVTVPVALGRQQVVPHLPDFLRQHPGVQIELDLSDRLHSLTQEGFDLAIRHTTTAPQTHV
AWKLCDTRSLLVASRDYLDARGAPRHPSELVDHSCLCYLRDNEPAAWSFEPDGRRRQRVSVPVRGSFAANNSEAMREAAL
GGLGIALLPDFSARRDLDAGRLVALLDGWRPSGAFGDHIFAIRPYSPVVPSAVRALVRHLRERLAGGFSGA
>Mature_311_residues
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTRSVRLTDAGQTLVDSTRDAFE
SIGQHFARVKDLAGEPRGLLRVTVPVALGRQQVVPHLPDFLRQHPGVQIELDLSDRLHSLTQEGFDLAIRHTTTAPQTHV
AWKLCDTRSLLVASRDYLDARGAPRHPSELVDHSCLCYLRDNEPAAWSFEPDGRRRQRVSVPVRGSFAANNSEAMREAAL
GGLGIALLPDFSARRDLDAGRLVALLDGWRPSGAFGDHIFAIRPYSPVVPSAVRALVRHLRERLAGGFSGA

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=277, Percent_Identity=29.9638989169675, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787128, Length=248, Percent_Identity=31.4516129032258, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87081978, Length=295, Percent_Identity=29.1525423728814, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI145693193, Length=264, Percent_Identity=30.3030303030303, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786401, Length=297, Percent_Identity=27.2727272727273, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787589, Length=262, Percent_Identity=30.1526717557252, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790011, Length=311, Percent_Identity=26.3665594855305, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789639, Length=249, Percent_Identity=27.710843373494, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789173, Length=258, Percent_Identity=28.6821705426357, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788706, Length=260, Percent_Identity=27.3076923076923, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI157672245, Length=120, Percent_Identity=35.8333333333333, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786448, Length=244, Percent_Identity=27.0491803278689, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33949; Mature: 33949

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCCC
SVRLTDAGQTLVDSTRDAFESIGQHFARVKDLAGEPRGLLRVTVPVALGRQQVVPHLPDF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCHHHHHHHHHH
LRQHPGVQIELDLSDRLHSLTQEGFDLAIRHTTTAPQTHVAWKLCDTRSLLVASRDYLDA
HHHCCCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCCHHHHHHHHHHHCC
RGAPRHPSELVDHSCLCYLRDNEPAAWSFEPDGRRRQRVSVPVRGSFAANNSEAMREAAL
CCCCCCHHHHHCCCEEEEEECCCCCEECCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHH
GGLGIALLPDFSARRDLDAGRLVALLDGWRPSGAFGDHIFAIRPYSPVVPSAVRALVRHL
CCCCEEECCCCHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
RERLAGGFSGA
HHHHCCCCCCC
>Mature Secondary Structure
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCCC
SVRLTDAGQTLVDSTRDAFESIGQHFARVKDLAGEPRGLLRVTVPVALGRQQVVPHLPDF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHCCCHHHHHHHHHH
LRQHPGVQIELDLSDRLHSLTQEGFDLAIRHTTTAPQTHVAWKLCDTRSLLVASRDYLDA
HHHCCCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCCHHHHHHHHHHHCC
RGAPRHPSELVDHSCLCYLRDNEPAAWSFEPDGRRRQRVSVPVRGSFAANNSEAMREAAL
CCCCCCHHHHHCCCEEEEEECCCCCEECCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHH
GGLGIALLPDFSARRDLDAGRLVALLDGWRPSGAFGDHIFAIRPYSPVVPSAVRALVRHL
CCCCEEECCCCHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
RERLAGGFSGA
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]