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The map label for this gene is aslA [H]

Identifier: 116624385

GI number: 116624385

Start: 6645815

End: 6647332

Strand: Reverse

Name: aslA [H]

Synonym: Acid_5306

Alternate gene names: 116624385

Gene position: 6647332-6645815 (Counterclockwise)

Preceding gene: 116624395

Following gene: 116624384

Centisome position: 66.7

GC content: 59.82

Gene sequence:

>1518_bases
GTGGCAACAAAGAAGAAACCGAATATTCTCATTCTCTGGGGTGACGACATCGGCTGGCTCAATGTCAGCGCCTACAATCA
CGGCATCATGGGCTATAAGACTCCGAACATCGACCGCCTGGCCAAAGAAGGTGCGATGTTTACCGACTGGTACGGCCAGC
AGAGCTGTACGGCCGGCCGCGCGGCGTTCATCACCGGCCAATCGCCCATCCGTACGGGCCTGACCAAGGTCGGGCTGCCC
GGCGCCAAGATCGGACTGCAGCCGGAAGACCCGACCATCGCGGAACTGCTCAAACCTCACGGGTATGTCTGCGGCCAGTT
CGGCAAGAACCACGTCGGCGACCGCGATGAATTTCTGCCCACCGTCCACGGCTTTGACGAATTCTTCGGTAACCTCTATC
ACCTCAACGCCGAAGAGGAACCGGAGTGCGTGGACTATCCGAAGAATCCCGAATTCAAGAAGAAGTTCGGGCCGCGCGGC
GTGCTGCATTGCTGGGCCAACCCGGACGGCACCCAGAAGATCGAAGACACCGGGCCTTTGAACAAAAAGCGCATGGAAAC
CATGGATGAGGAGATCACCGCCAGTGCAATGGACTTCATGGAGCGCCAGGTCAAGGCCGACAAGCCCTTCTTTCTGTGGT
GGAACTCCACCAAGATGCACGTTTGGACCCACCTGAAGAAGGAGTGTCAAGGCGTAACCGGACTCGGCGTCTATGCCGAC
GGCATGGTGGAGCATGACCGTCAAGTCGGCCAAATGCTCGACAAGCTCGAGGAATTGGGCATCGCCGACAACACCATTGT
GATGTACTCCACCGATAACGGCGCCGAAGAGTTGAGTTGGCCCGATGGCGGCACCACCCCGTTCCGCGGCGAGAAGGATA
CCAACTGGGAAGGCGCCTGGCGCGTGCCGTGCGCGATCCGCTGGCCGGGTGTGATCAAACCGGGGACGGTATCCAACGAG
GTCTACTCGCACCAGGATATGCTGCCGACCCTGGTGGCGGCAGCCGGCGAACCCGATATCGTCGCCAAATGCAAGCAGGG
CTATAAGGCCGGCACTAAGACATTCAAGGTGTACCTAGATGGCTTCAACCTCGGGCCGCATCTGAAGGGAGAGGTCAAGG
AGAATCCGCGCCCCGGATTCCTTTACTGGAGCGATGAAGGCGACCTGATGGCGCTTCGCTACGGCGATTGGAAGGTCCAC
TTCCAGGTGCAGCGCGCAGAAGGCATGGGTGCGTGGCAGGAGCCGTTCGTGACCCTGCGATGTCCTATGCTCTTCAATTT
GCGCATGGACCCCTTCGAAAATGCCGAGGTGGCCGCCGACGTCTTCTACAACAAGTGGCGGGCGGATCGTATGTTCATGC
TGATACCGGCCGGCGCCCTGGTGCACCAGTACATGCAGACGATGATCGAGTTCCCGCCCCGGCAATCGCCGGAGAGTTGG
TCCGTCGGAAATGTGATGGAGAAACTCCGGCAGCATGCGGCGGCGCTCGAAAGCGGCTCGGCCATCGGGGTGAAGTAA

Upstream 100 bases:

>100_bases
ATGATAGCGCGGGTCGCCCCTTGGCTCGTGCGGTCCGGCGAAGATCCTGACTCCCTTGCCCCCATTTTGGAATCCCCTCC
CTTTTGCGAAGGAGACGCGA

Downstream 100 bases:

>100_bases
GCCGCTCCAGGAATACGCGTGGCGGGGCTACCGTTCTCCCGCCAGGCGCGTCCATTCCCTCGATGCGCGGCCTGACACTC
ATCGTTCTCTCCCTGTCAAT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MATKKKPNILILWGDDIGWLNVSAYNHGIMGYKTPNIDRLAKEGAMFTDWYGQQSCTAGRAAFITGQSPIRTGLTKVGLP
GAKIGLQPEDPTIAELLKPHGYVCGQFGKNHVGDRDEFLPTVHGFDEFFGNLYHLNAEEEPECVDYPKNPEFKKKFGPRG
VLHCWANPDGTQKIEDTGPLNKKRMETMDEEITASAMDFMERQVKADKPFFLWWNSTKMHVWTHLKKECQGVTGLGVYAD
GMVEHDRQVGQMLDKLEELGIADNTIVMYSTDNGAEELSWPDGGTTPFRGEKDTNWEGAWRVPCAIRWPGVIKPGTVSNE
VYSHQDMLPTLVAAAGEPDIVAKCKQGYKAGTKTFKVYLDGFNLGPHLKGEVKENPRPGFLYWSDEGDLMALRYGDWKVH
FQVQRAEGMGAWQEPFVTLRCPMLFNLRMDPFENAEVAADVFYNKWRADRMFMLIPAGALVHQYMQTMIEFPPRQSPESW
SVGNVMEKLRQHAAALESGSAIGVK

Sequences:

>Translated_505_residues
MATKKKPNILILWGDDIGWLNVSAYNHGIMGYKTPNIDRLAKEGAMFTDWYGQQSCTAGRAAFITGQSPIRTGLTKVGLP
GAKIGLQPEDPTIAELLKPHGYVCGQFGKNHVGDRDEFLPTVHGFDEFFGNLYHLNAEEEPECVDYPKNPEFKKKFGPRG
VLHCWANPDGTQKIEDTGPLNKKRMETMDEEITASAMDFMERQVKADKPFFLWWNSTKMHVWTHLKKECQGVTGLGVYAD
GMVEHDRQVGQMLDKLEELGIADNTIVMYSTDNGAEELSWPDGGTTPFRGEKDTNWEGAWRVPCAIRWPGVIKPGTVSNE
VYSHQDMLPTLVAAAGEPDIVAKCKQGYKAGTKTFKVYLDGFNLGPHLKGEVKENPRPGFLYWSDEGDLMALRYGDWKVH
FQVQRAEGMGAWQEPFVTLRCPMLFNLRMDPFENAEVAADVFYNKWRADRMFMLIPAGALVHQYMQTMIEFPPRQSPESW
SVGNVMEKLRQHAAALESGSAIGVK
>Mature_504_residues
ATKKKPNILILWGDDIGWLNVSAYNHGIMGYKTPNIDRLAKEGAMFTDWYGQQSCTAGRAAFITGQSPIRTGLTKVGLPG
AKIGLQPEDPTIAELLKPHGYVCGQFGKNHVGDRDEFLPTVHGFDEFFGNLYHLNAEEEPECVDYPKNPEFKKKFGPRGV
LHCWANPDGTQKIEDTGPLNKKRMETMDEEITASAMDFMERQVKADKPFFLWWNSTKMHVWTHLKKECQGVTGLGVYADG
MVEHDRQVGQMLDKLEELGIADNTIVMYSTDNGAEELSWPDGGTTPFRGEKDTNWEGAWRVPCAIRWPGVIKPGTVSNEV
YSHQDMLPTLVAAAGEPDIVAKCKQGYKAGTKTFKVYLDGFNLGPHLKGEVKENPRPGFLYWSDEGDLMALRYGDWKVHF
QVQRAEGMGAWQEPFVTLRCPMLFNLRMDPFENAEVAADVFYNKWRADRMFMLIPAGALVHQYMQTMIEFPPRQSPESWS
VGNVMEKLRQHAAALESGSAIGVK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=458, Percent_Identity=31.4410480349345, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI146229329, Length=458, Percent_Identity=31.4410480349345, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI6005990, Length=458, Percent_Identity=31.4410480349345, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI146229324, Length=458, Percent_Identity=31.4410480349345, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI4503899, Length=515, Percent_Identity=30.4854368932039, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI45430057, Length=454, Percent_Identity=27.7533039647577, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI146229327, Length=384, Percent_Identity=29.6875, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI53831991, Length=510, Percent_Identity=27.843137254902, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI58743319, Length=577, Percent_Identity=27.3830155979203, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI31742482, Length=531, Percent_Identity=26.1770244821092, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI71852584, Length=567, Percent_Identity=26.63139329806, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI38569405, Length=449, Percent_Identity=27.3942093541203, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI38569407, Length=406, Percent_Identity=28.0788177339901, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI109389362, Length=488, Percent_Identity=25.2049180327869, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI59797060, Length=526, Percent_Identity=25.2851711026616, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI157266309, Length=146, Percent_Identity=39.041095890411, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71852586, Length=153, Percent_Identity=34.640522875817, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1790233, Length=501, Percent_Identity=30.1397205588822, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081924, Length=371, Percent_Identity=25.0673854447439, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115533416, Length=419, Percent_Identity=25.2983293556086, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17559078, Length=282, Percent_Identity=29.7872340425532, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24666175, Length=396, Percent_Identity=29.040404040404, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24666109, Length=418, Percent_Identity=27.2727272727273, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366397, Length=396, Percent_Identity=28.5353535353535, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281366395, Length=396, Percent_Identity=28.5353535353535, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24666163, Length=396, Percent_Identity=28.5353535353535, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281363223, Length=427, Percent_Identity=26.6978922716628, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 56795; Mature: 56664

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKKKPNILILWGDDIGWLNVSAYNHGIMGYKTPNIDRLAKEGAMFTDWYGQQSCTAGR
CCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCC
AAFITGQSPIRTGLTKVGLPGAKIGLQPEDPTIAELLKPHGYVCGQFGKNHVGDRDEFLP
EEEEECCCHHHHCHHHCCCCCCEECCCCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHCC
TVHGFDEFFGNLYHLNAEEEPECVDYPKNPEFKKKFGPRGVLHCWANPDGTQKIEDTGPL
HHCCHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCC
NKKRMETMDEEITASAMDFMERQVKADKPFFLWWNSTKMHVWTHLKKECQGVTGLGVYAD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHHHHHCCCCCCCEEEC
GMVEHDRQVGQMLDKLEELGIADNTIVMYSTDNGAEELSWPDGGTTPFRGEKDTNWEGAW
CHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
RVPCAIRWPGVIKPGTVSNEVYSHQDMLPTLVAAAGEPDIVAKCKQGYKAGTKTFKVYLD
ECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEEE
GFNLGPHLKGEVKENPRPGFLYWSDEGDLMALRYGDWKVHFQVQRAEGMGAWQEPFVTLR
CCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEEEEEEEEECCCCCCCCCCCEEEE
CPMLFNLRMDPFENAEVAADVFYNKWRADRMFMLIPAGALVHQYMQTMIEFPPRQSPESW
CCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCC
SVGNVMEKLRQHAAALESGSAIGVK
CHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATKKKPNILILWGDDIGWLNVSAYNHGIMGYKTPNIDRLAKEGAMFTDWYGQQSCTAGR
CCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCC
AAFITGQSPIRTGLTKVGLPGAKIGLQPEDPTIAELLKPHGYVCGQFGKNHVGDRDEFLP
EEEEECCCHHHHCHHHCCCCCCEECCCCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHCC
TVHGFDEFFGNLYHLNAEEEPECVDYPKNPEFKKKFGPRGVLHCWANPDGTQKIEDTGPL
HHCCHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCC
NKKRMETMDEEITASAMDFMERQVKADKPFFLWWNSTKMHVWTHLKKECQGVTGLGVYAD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHHHHHCCCCCCCEEEC
GMVEHDRQVGQMLDKLEELGIADNTIVMYSTDNGAEELSWPDGGTTPFRGEKDTNWEGAW
CHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
RVPCAIRWPGVIKPGTVSNEVYSHQDMLPTLVAAAGEPDIVAKCKQGYKAGTKTFKVYLD
ECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEEE
GFNLGPHLKGEVKENPRPGFLYWSDEGDLMALRYGDWKVHFQVQRAEGMGAWQEPFVTLR
CCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCEEEEEEEEECCCCCCCCCCCEEEE
CPMLFNLRMDPFENAEVAADVFYNKWRADRMFMLIPAGALVHQYMQTMIEFPPRQSPESW
CCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCC
SVGNVMEKLRQHAAALESGSAIGVK
CHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]