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The map label for this gene is ptpA [H]

Identifier: 116624381

GI number: 116624381

Start: 6640636

End: 6642810

Strand: Reverse

Name: ptpA [H]

Synonym: Acid_5302

Alternate gene names: 116624381

Gene position: 6642810-6640636 (Counterclockwise)

Preceding gene: 116624383

Following gene: 116624380

Centisome position: 66.66

GC content: 63.63

Gene sequence:

>2175_bases
ATGACGAAGCTTAGCCTCATCCTTCTTCTCTCCCTCGCCGCGTTCGCGCAAAAGAAGCCCATCACGCTCGAGTCCCTCCA
GGCCGGGGGACGCGGCGGCGGACGTGGCGGCGCCGGGTTCGGCGGGCCGCCCACATGGATGCCCGATGGCAAGACCTTCG
TCACCCGCCAGGGCCGCAGCCTCATGGTTTACGACCCCGCTACCCAGACCTCGAAGCTCCTCATCGATACCACTCCGATC
GACGCCGCTGCCGTCAATCCGCCCGCCGCCGACGGCCCCACCGATTGGACGAATCGCCGCGCGCGCGCCGGCGGCATGCA
GTTCTCCGCCGACGGCCAGTCCCTGCTCTACGCCACCGGCGGCGATCTCTTCCTCATCCACCCCGCCACCGGAAAGTGGG
ACCAGCTCACCAAGACGCCCGTACCCGAGCTCGACGCCAAACTTTCCCCCGATACCTCCGCGGTCGCCTTCCGCCGCGGC
TGGGATCTCTACACCGTGAACACCGCCACGCTCAAGGAAACCCGACTCACCAAGGACGGCTCCGAAACCCTCCGAAACGG
CATCCCCGATTGGGTCTATCCCGAGGAACTCACGCTCGGTACCGGCTTCTGGTGGTCGCCCGATTCCAAATCCCTCTGCT
ACCTGCAGTTCGATTCCAGCCGCGAGCCCGTCTTCCCGCACGCCGACATGCTCGGCACGCGCGCCTTCGCCGAGCCCGAG
CGCTATCCGCAGGCCGGCGAGAACAACCCCGATATTCACCTCGGCATCATCGCGGCCACCGGCGGCCCCACCAAGTGGCT
CGAAGTGGGCGATACCCGCAATGCCTTCCTGATCGCGCGCGCCGGCTGGATGCCCAATTCGCGCGGCGTCTACATGCTGC
GCATGAACCGCGTGCAGAACAAGATCGAGATGATCACGATCGACGCCGAATCCGGGGAGGCCGCCAGCGTCTTCAAGGAA
TCCGACCCCTTCTGGATCAACCTGGAAGGCGATATCGAGTTTCTCAAGGATGGCAAGCGCTTCCTCTGGACCAGCCAGCG
CGACGGCGGCTACCGCCACATCTTCATCTCCTCGAACGATGGCAAGTCTATCAAGCAACTGACCAAGGGACCCTGGGAAG
TCACCGCCATCAACGCCGTGGATGAAGCCGGCGATCGCATCTACTTCACCTCCACCGAGCCCACCCCGCTCGAGCGCCAC
CTCTACACCATCAAGCTCGATGGCACCGGCAAGCGCCAGTTGACGGCCGCGAATTTCACACACAACGTCTCCGTCAGTCC
CAACGGCGCTTACTACCTGGATACCTACTCGAATCTGACGACCCCCGGCCGCACGACCCTGCACTCCGGCGACGGCAAGG
AACTCGCGGTCTACCGTGAGGCCGACCGCACACAGGCCGACGAGTACGAAATTCTGCCCACCGAGATCGTCAAGTTCAAG
GGCCCCGACGGCAGCGAACTCTACGGCCGCCTGATCAGGCCCGCCGGCTTCCAGCCCGGCAGGAAGTATCCTGTGATCGT
ACCGGTCTATGGCGGCCCCGGAGTCGGGTCGCCGGTGCGCAATGCCTGGTCCGGAATCGGCATGGACCAGGTCTACGCGC
ACAAGGGCTACGTTGTGTGGCAATGCGAGAATCGCGGCATCATGGGGCGCGGCCACCAGCTCGAGACCGCCATCTATCAT
CATCTCGGCGAGGCCGAACTCGCCGACCAGGTGGCCGGTGTGAAGTACCTGGTCTCCCTCGGCTTCGCCGACCCCGCGCG
CGTCGGCATCACCGGCACCAGCTACGGCGGCTTTATGACAATCAACGCCATGCTCAACGCGCCAGACACCTTCCACGCCG
GCGTCTCCGGCGCCCCCGTTACCAGTTGGATCAACTACGACACCATCTACACGGAGCGCTACATGGGCCTTCCCAAAGAG
AACCCCGATGGCTACCGTGATACGGCCCTGCCGCCCAAGGCGAAAAATCTCAAAGGCAAGCTGCTCATCTTCCACAATTT
CGAAGATGACAACGTCCTCTTCCAGAACACACTGCAGATGACCAATGCCCTGCAGCTCGCCGGCAAGCAATTCGAGTTCA
TGCTGTACCCGCAAAAGACTCATGGCGTCACGGGCGCCGCTTCGCGCCAGCTCCAGCAGATGACGCTCGACTTCTTCGAT
CGCAATTTGAAGTAG

Upstream 100 bases:

>100_bases
CTGCCACCGAAATCGCGAGTACGCCAAGCCACCAGAGTTTCACGTCTTCATTCTAGTCTTACCGCTCGCCGCGTCCACCC
CACTGCTACAATCGCTAACG

Downstream 100 bases:

>100_bases
GATGAACCGTCCGGTTCGCGCCTCCTGAACCGGACGGTTCACAGAATACCCGCCTTACACGCATTCTCAACGACTTGCGT
CCGTCCTGCTGCGTGGCCGC

Product: peptidase S9B dipeptidylpeptidase IV subunit

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 724; Mature: 723

Protein sequence:

>724_residues
MTKLSLILLLSLAAFAQKKPITLESLQAGGRGGGRGGAGFGGPPTWMPDGKTFVTRQGRSLMVYDPATQTSKLLIDTTPI
DAAAVNPPAADGPTDWTNRRARAGGMQFSADGQSLLYATGGDLFLIHPATGKWDQLTKTPVPELDAKLSPDTSAVAFRRG
WDLYTVNTATLKETRLTKDGSETLRNGIPDWVYPEELTLGTGFWWSPDSKSLCYLQFDSSREPVFPHADMLGTRAFAEPE
RYPQAGENNPDIHLGIIAATGGPTKWLEVGDTRNAFLIARAGWMPNSRGVYMLRMNRVQNKIEMITIDAESGEAASVFKE
SDPFWINLEGDIEFLKDGKRFLWTSQRDGGYRHIFISSNDGKSIKQLTKGPWEVTAINAVDEAGDRIYFTSTEPTPLERH
LYTIKLDGTGKRQLTAANFTHNVSVSPNGAYYLDTYSNLTTPGRTTLHSGDGKELAVYREADRTQADEYEILPTEIVKFK
GPDGSELYGRLIRPAGFQPGRKYPVIVPVYGGPGVGSPVRNAWSGIGMDQVYAHKGYVVWQCENRGIMGRGHQLETAIYH
HLGEAELADQVAGVKYLVSLGFADPARVGITGTSYGGFMTINAMLNAPDTFHAGVSGAPVTSWINYDTIYTERYMGLPKE
NPDGYRDTALPPKAKNLKGKLLIFHNFEDDNVLFQNTLQMTNALQLAGKQFEFMLYPQKTHGVTGAASRQLQQMTLDFFD
RNLK

Sequences:

>Translated_724_residues
MTKLSLILLLSLAAFAQKKPITLESLQAGGRGGGRGGAGFGGPPTWMPDGKTFVTRQGRSLMVYDPATQTSKLLIDTTPI
DAAAVNPPAADGPTDWTNRRARAGGMQFSADGQSLLYATGGDLFLIHPATGKWDQLTKTPVPELDAKLSPDTSAVAFRRG
WDLYTVNTATLKETRLTKDGSETLRNGIPDWVYPEELTLGTGFWWSPDSKSLCYLQFDSSREPVFPHADMLGTRAFAEPE
RYPQAGENNPDIHLGIIAATGGPTKWLEVGDTRNAFLIARAGWMPNSRGVYMLRMNRVQNKIEMITIDAESGEAASVFKE
SDPFWINLEGDIEFLKDGKRFLWTSQRDGGYRHIFISSNDGKSIKQLTKGPWEVTAINAVDEAGDRIYFTSTEPTPLERH
LYTIKLDGTGKRQLTAANFTHNVSVSPNGAYYLDTYSNLTTPGRTTLHSGDGKELAVYREADRTQADEYEILPTEIVKFK
GPDGSELYGRLIRPAGFQPGRKYPVIVPVYGGPGVGSPVRNAWSGIGMDQVYAHKGYVVWQCENRGIMGRGHQLETAIYH
HLGEAELADQVAGVKYLVSLGFADPARVGITGTSYGGFMTINAMLNAPDTFHAGVSGAPVTSWINYDTIYTERYMGLPKE
NPDGYRDTALPPKAKNLKGKLLIFHNFEDDNVLFQNTLQMTNALQLAGKQFEFMLYPQKTHGVTGAASRQLQQMTLDFFD
RNLK
>Mature_723_residues
TKLSLILLLSLAAFAQKKPITLESLQAGGRGGGRGGAGFGGPPTWMPDGKTFVTRQGRSLMVYDPATQTSKLLIDTTPID
AAAVNPPAADGPTDWTNRRARAGGMQFSADGQSLLYATGGDLFLIHPATGKWDQLTKTPVPELDAKLSPDTSAVAFRRGW
DLYTVNTATLKETRLTKDGSETLRNGIPDWVYPEELTLGTGFWWSPDSKSLCYLQFDSSREPVFPHADMLGTRAFAEPER
YPQAGENNPDIHLGIIAATGGPTKWLEVGDTRNAFLIARAGWMPNSRGVYMLRMNRVQNKIEMITIDAESGEAASVFKES
DPFWINLEGDIEFLKDGKRFLWTSQRDGGYRHIFISSNDGKSIKQLTKGPWEVTAINAVDEAGDRIYFTSTEPTPLERHL
YTIKLDGTGKRQLTAANFTHNVSVSPNGAYYLDTYSNLTTPGRTTLHSGDGKELAVYREADRTQADEYEILPTEIVKFKG
PDGSELYGRLIRPAGFQPGRKYPVIVPVYGGPGVGSPVRNAWSGIGMDQVYAHKGYVVWQCENRGIMGRGHQLETAIYHH
LGEAELADQVAGVKYLVSLGFADPARVGITGTSYGGFMTINAMLNAPDTFHAGVSGAPVTSWINYDTIYTERYMGLPKEN
PDGYRDTALPPKAKNLKGKLLIFHNFEDDNVLFQNTLQMTNALQLAGKQFEFMLYPQKTHGVTGAASRQLQQMTLDFFDR
NLK

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=685, Percent_Identity=30.0729927007299, Blast_Score=269, Evalue=9e-72,
Organism=Homo sapiens, GI37577089, Length=685, Percent_Identity=30.0729927007299, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI194394146, Length=680, Percent_Identity=29.1176470588235, Blast_Score=245, Evalue=1e-64,
Organism=Homo sapiens, GI86792863, Length=767, Percent_Identity=26.4667535853977, Blast_Score=223, Evalue=7e-58,
Organism=Homo sapiens, GI86792774, Length=767, Percent_Identity=26.4667535853977, Blast_Score=223, Evalue=7e-58,
Organism=Homo sapiens, GI86792778, Length=767, Percent_Identity=26.4667535853977, Blast_Score=222, Evalue=9e-58,
Organism=Homo sapiens, GI16933540, Length=641, Percent_Identity=28.2371294851794, Blast_Score=216, Evalue=6e-56,
Organism=Homo sapiens, GI18765694, Length=605, Percent_Identity=28.099173553719, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI85787627, Length=582, Percent_Identity=28.6941580756014, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI52426756, Length=582, Percent_Identity=28.6941580756014, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI295849272, Length=582, Percent_Identity=28.6941580756014, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI295842359, Length=582, Percent_Identity=28.6941580756014, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI295842403, Length=582, Percent_Identity=28.6941580756014, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI37577091, Length=684, Percent_Identity=26.7543859649123, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI18450278, Length=477, Percent_Identity=26.8343815513627, Blast_Score=137, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17508017, Length=646, Percent_Identity=26.4705882352941, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17508019, Length=646, Percent_Identity=26.4705882352941, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17564634, Length=590, Percent_Identity=27.2881355932203, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17564632, Length=590, Percent_Identity=27.2881355932203, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17550672, Length=602, Percent_Identity=25.4152823920266, Blast_Score=145, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17552908, Length=277, Percent_Identity=25.6317689530686, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25144540, Length=278, Percent_Identity=25.1798561151079, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=278, Percent_Identity=25.5395683453237, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321817, Length=638, Percent_Identity=26.4890282131661, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324793, Length=601, Percent_Identity=26.955074875208, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45551969, Length=693, Percent_Identity=26.5512265512266, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI45550825, Length=693, Percent_Identity=26.5512265512266, Blast_Score=229, Evalue=5e-60,
Organism=Drosophila melanogaster, GI45553511, Length=693, Percent_Identity=26.5512265512266, Blast_Score=229, Evalue=5e-60,
Organism=Drosophila melanogaster, GI17933704, Length=730, Percent_Identity=26.4383561643836, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI221331178, Length=730, Percent_Identity=26.4383561643836, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI161083744, Length=730, Percent_Identity=26.4383561643836, Blast_Score=197, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24582032, Length=573, Percent_Identity=29.6684118673647, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24582257, Length=223, Percent_Identity=33.6322869955157, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI221372263, Length=675, Percent_Identity=23.2592592592593, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45551475, Length=675, Percent_Identity=23.2592592592593, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221372266, Length=675, Percent_Identity=23.2592592592593, Blast_Score=108, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 79714; Mature: 79583

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLSLILLLSLAAFAQKKPITLESLQAGGRGGGRGGAGFGGPPTWMPDGKTFVTRQGRS
CCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCE
LMVYDPATQTSKLLIDTTPIDAAAVNPPAADGPTDWTNRRARAGGMQFSADGQSLLYATG
EEEECCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEC
GDLFLIHPATGKWDQLTKTPVPELDAKLSPDTSAVAFRRGWDLYTVNTATLKETRLTKDG
CCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCEEEHHHCCCCC
SETLRNGIPDWVYPEELTLGTGFWWSPDSKSLCYLQFDSSREPVFPHADMLGTRAFAEPE
HHHHHCCCCCCCCCCCEEECCCEEECCCCCCEEEEEECCCCCCCCCCHHHHCCHHHCCCH
RYPQAGENNPDIHLGIIAATGGPTKWLEVGDTRNAFLIARAGWMPNSRGVYMLRMNRVQN
HCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCC
KIEMITIDAESGEAASVFKESDPFWINLEGDIEFLKDGKRFLWTSQRDGGYRHIFISSND
EEEEEEEECCCCCHHHHEECCCCEEEEECCCCCEECCCCEEEEECCCCCCEEEEEEECCC
GKSIKQLTKGPWEVTAINAVDEAGDRIYFTSTEPTPLERHLYTIKLDGTGKRQLTAANFT
CHHHHHHHCCCEEEEEEECHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCE
HNVSVSPNGAYYLDTYSNLTTPGRTTLHSGDGKELAVYREADRTQADEYEILPTEIVKFK
EEEEECCCCCEEEECCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCEEECCEEEEEEC
GPDGSELYGRLIRPAGFQPGRKYPVIVPVYGGPGVGSPVRNAWSGIGMDQVYAHKGYVVW
CCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHHEECCCEEEE
QCENRGIMGRGHQLETAIYHHLGEAELADQVAGVKYLVSLGFADPARVGITGTSYGGFMT
EECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCEEE
INAMLNAPDTFHAGVSGAPVTSWINYDTIYTERYMGLPKENPDGYRDTALPPKAKNLKGK
EEEEECCCCHHCCCCCCCCEEEEECCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
LLIFHNFEDDNVLFQNTLQMTNALQLAGKQFEFMLYPQKTHGVTGAASRQLQQMTLDFFD
EEEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHHHH
RNLK
CCCC
>Mature Secondary Structure 
TKLSLILLLSLAAFAQKKPITLESLQAGGRGGGRGGAGFGGPPTWMPDGKTFVTRQGRS
CHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCE
LMVYDPATQTSKLLIDTTPIDAAAVNPPAADGPTDWTNRRARAGGMQFSADGQSLLYATG
EEEECCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEC
GDLFLIHPATGKWDQLTKTPVPELDAKLSPDTSAVAFRRGWDLYTVNTATLKETRLTKDG
CCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCEEEHHHCCCCC
SETLRNGIPDWVYPEELTLGTGFWWSPDSKSLCYLQFDSSREPVFPHADMLGTRAFAEPE
HHHHHCCCCCCCCCCCEEECCCEEECCCCCCEEEEEECCCCCCCCCCHHHHCCHHHCCCH
RYPQAGENNPDIHLGIIAATGGPTKWLEVGDTRNAFLIARAGWMPNSRGVYMLRMNRVQN
HCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCC
KIEMITIDAESGEAASVFKESDPFWINLEGDIEFLKDGKRFLWTSQRDGGYRHIFISSND
EEEEEEEECCCCCHHHHEECCCCEEEEECCCCCEECCCCEEEEECCCCCCEEEEEEECCC
GKSIKQLTKGPWEVTAINAVDEAGDRIYFTSTEPTPLERHLYTIKLDGTGKRQLTAANFT
CHHHHHHHCCCEEEEEEECHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCE
HNVSVSPNGAYYLDTYSNLTTPGRTTLHSGDGKELAVYREADRTQADEYEILPTEIVKFK
EEEEECCCCCEEEECCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCCEEECCEEEEEEC
GPDGSELYGRLIRPAGFQPGRKYPVIVPVYGGPGVGSPVRNAWSGIGMDQVYAHKGYVVW
CCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHHEECCCEEEE
QCENRGIMGRGHQLETAIYHHLGEAELADQVAGVKYLVSLGFADPARVGITGTSYGGFMT
EECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCEEE
INAMLNAPDTFHAGVSGAPVTSWINYDTIYTERYMGLPKENPDGYRDTALPPKAKNLKGK
EEEEECCCCHHCCCCCCCCEEEEECCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
LLIFHNFEDDNVLFQNTLQMTNALQLAGKQFEFMLYPQKTHGVTGAASRQLQQMTLDFFD
EEEEEECCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHHHH
RNLK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA