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The map label for this gene is zwf [H]

Identifier: 116624360

GI number: 116624360

Start: 6617873

End: 6619417

Strand: Reverse

Name: zwf [H]

Synonym: Acid_5281

Alternate gene names: 116624360

Gene position: 6619417-6617873 (Counterclockwise)

Preceding gene: 116624363

Following gene: 116624359

Centisome position: 66.42

GC content: 61.88

Gene sequence:

>1545_bases
ATGTTGGACTTAATGCCCAACGAGAACCCCTTTCAAGATCCGCTCCGCTTTGAACGGCAAGTTCCCGAGTGTGTCATCGT
GATCTTCGGCGCCAATGGCGACCTGACCAAGCGCAAACTGCTGCCGGCGCTGTATCGACTGGCATACGACCGGCGGCTGG
CGGCGGGCTTTGCGGTAGTGGGCATCTCGCGCACGCCGCTTTCCGACGATCAATTTCGCGCGAAGATGCGCGAGAGCGTG
GAGCAATTTTCCGAAGATACCAAGCTGGATGAAGAGGTTTGGGGGGCGTTCGCGCGCGGCCTGTATTATGTCGCGGGCGA
CGTTGCGGATGCCGGACTGTACCAGCGTGTCAGCGAGAAAGTGGGGCAGATCGAGACCGAGCGTCACACGGGCGGCAACG
TGCTGTTCTATCTCTCTACTCAGCCGAGCCAGTACGCGGAGATCGCGCACGGCATCGGTGTGGCGGGAATGGGGAAGGGA
AATGGCTGGCGGAGGCTGGTGGTGGAAAAGCCGTTCGGCCACGATCTGGCCAGCGCGCGCGAACTGAGCAACCGGCTGCA
CGAGGTCTTTGACGAATCCGACGTCTACCGCATCGATCACTACCTGGGCAAAGAGACGGTGCAGAACATTCTGGCCTTCC
GTTTCGGCAACGGTATTTTCGAGCCGTTATGGAACCGGCGGTATGTGAATCACGTGCAGATCACGGGTGCGGAATCGATC
GGCGTGGAAGGGCGCGGCGCATATTACCAAGAGGCCGGCGCGCTCGACGACATGATCCAGAACCATCTGCTCCAGGTGAT
GGCGACGGTGGCAATGGAGCCGAGCGCGAGCTTCCGCGCCAACAGCGTGCGCGACGAGCGCTCCAAGCTGCTGCGCTCGA
TTCGTCCGATGACCCGCGACGAAGTGCTCCAGAACGCGGTGGCGGGGCAGTACGGACCGGCGCGCATTGGCGGCGAGGAC
GTCCCGGGCTTCCGTCAGGAACAGGGCGTGGATCCGAATTCGCAGACCAACACTTACGCCGCGGTCACGTTCTTTGTGGA
CAACTGGCGATGGGCGGGAGTGCCGTTTTACGTGCGCACAGGCAAGCGGCTGGCCAAGCGGGTCAGCGAAATCGCCATTC
AATTCAACTCGGCGCCGCTGCACCTGTTCAATCAGGATTCGGGCGGACCGTCGGGTGACCCGGGTGTGAACCTGCTGATT
CTGCGCATTCAGCCCGAGGAGGGGATCTCGCTGAAGTTCCTCTCGAAACGTCCGGGCCAGGGGATGACGCTGCGCCCGGT
GTCCATGGATTTCAACTACGGGTCGAGCTTCGGCGAGCGGTCGCCTTCGGCATACGAGACGCTGCTTTTGGACGCGATAA
TCGGCGACCCGACGCTGTATACGAGGCAGGACATGGTGGAAGCGAGCTGGAGCGTAGTGGAGCCGATTCAGAATACGTGG
CGCGAGACCAAGTTCGATTTTCCGAATTATCCGGCAGGGAGCTGGGGACCGCAAGCCGCGGATGTGATGCTGGCGCGGCG
CGGCCACGTGTGGAGGAAACCCTGA

Upstream 100 bases:

>100_bases
TAATAAAAGTAAGAATTCTCACGATCCTCATTGACGAACAAGTCTAGCAGACATTGACATCTGAAAAGGTGGTCCGGCAG
TCATTCGGCCCTCGCGTGAT

Downstream 100 bases:

>100_bases
TGTCCGCCACGGTCGCGCCCGACAAAATTCTCAAGGAACTGGCCGCGCTGTGGACCCAGCAGGGCAAGGAAGGCGAGTCT
GGCGTGCTGCGGGCCTGCTC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MLDLMPNENPFQDPLRFERQVPECVIVIFGANGDLTKRKLLPALYRLAYDRRLAAGFAVVGISRTPLSDDQFRAKMRESV
EQFSEDTKLDEEVWGAFARGLYYVAGDVADAGLYQRVSEKVGQIETERHTGGNVLFYLSTQPSQYAEIAHGIGVAGMGKG
NGWRRLVVEKPFGHDLASARELSNRLHEVFDESDVYRIDHYLGKETVQNILAFRFGNGIFEPLWNRRYVNHVQITGAESI
GVEGRGAYYQEAGALDDMIQNHLLQVMATVAMEPSASFRANSVRDERSKLLRSIRPMTRDEVLQNAVAGQYGPARIGGED
VPGFRQEQGVDPNSQTNTYAAVTFFVDNWRWAGVPFYVRTGKRLAKRVSEIAIQFNSAPLHLFNQDSGGPSGDPGVNLLI
LRIQPEEGISLKFLSKRPGQGMTLRPVSMDFNYGSSFGERSPSAYETLLLDAIIGDPTLYTRQDMVEASWSVVEPIQNTW
RETKFDFPNYPAGSWGPQAADVMLARRGHVWRKP

Sequences:

>Translated_514_residues
MLDLMPNENPFQDPLRFERQVPECVIVIFGANGDLTKRKLLPALYRLAYDRRLAAGFAVVGISRTPLSDDQFRAKMRESV
EQFSEDTKLDEEVWGAFARGLYYVAGDVADAGLYQRVSEKVGQIETERHTGGNVLFYLSTQPSQYAEIAHGIGVAGMGKG
NGWRRLVVEKPFGHDLASARELSNRLHEVFDESDVYRIDHYLGKETVQNILAFRFGNGIFEPLWNRRYVNHVQITGAESI
GVEGRGAYYQEAGALDDMIQNHLLQVMATVAMEPSASFRANSVRDERSKLLRSIRPMTRDEVLQNAVAGQYGPARIGGED
VPGFRQEQGVDPNSQTNTYAAVTFFVDNWRWAGVPFYVRTGKRLAKRVSEIAIQFNSAPLHLFNQDSGGPSGDPGVNLLI
LRIQPEEGISLKFLSKRPGQGMTLRPVSMDFNYGSSFGERSPSAYETLLLDAIIGDPTLYTRQDMVEASWSVVEPIQNTW
RETKFDFPNYPAGSWGPQAADVMLARRGHVWRKP
>Mature_514_residues
MLDLMPNENPFQDPLRFERQVPECVIVIFGANGDLTKRKLLPALYRLAYDRRLAAGFAVVGISRTPLSDDQFRAKMRESV
EQFSEDTKLDEEVWGAFARGLYYVAGDVADAGLYQRVSEKVGQIETERHTGGNVLFYLSTQPSQYAEIAHGIGVAGMGKG
NGWRRLVVEKPFGHDLASARELSNRLHEVFDESDVYRIDHYLGKETVQNILAFRFGNGIFEPLWNRRYVNHVQITGAESI
GVEGRGAYYQEAGALDDMIQNHLLQVMATVAMEPSASFRANSVRDERSKLLRSIRPMTRDEVLQNAVAGQYGPARIGGED
VPGFRQEQGVDPNSQTNTYAAVTFFVDNWRWAGVPFYVRTGKRLAKRVSEIAIQFNSAPLHLFNQDSGGPSGDPGVNLLI
LRIQPEEGISLKFLSKRPGQGMTLRPVSMDFNYGSSFGERSPSAYETLLLDAIIGDPTLYTRQDMVEASWSVVEPIQNTW
RETKFDFPNYPAGSWGPQAADVMLARRGHVWRKP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=37.7049180327869, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=37.7049180327869, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI52145310, Length=476, Percent_Identity=30.4621848739496, Blast_Score=178, Evalue=9e-45,
Organism=Escherichia coli, GI1788158, Length=494, Percent_Identity=39.4736842105263, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17538218, Length=504, Percent_Identity=34.9206349206349, Blast_Score=331, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6324088, Length=504, Percent_Identity=34.5238095238095, Blast_Score=300, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24643350, Length=489, Percent_Identity=34.560327198364, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24643352, Length=489, Percent_Identity=34.560327198364, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI221513548, Length=493, Percent_Identity=29.6146044624746, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57625; Mature: 57625

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00069 G6P_DEHYDROGENASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLMPNENPFQDPLRFERQVPECVIVIFGANGDLTKRKLLPALYRLAYDRRLAAGFAVV
CCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEE
GISRTPLSDDQFRAKMRESVEQFSEDTKLDEEVWGAFARGLYYVAGDVADAGLYQRVSEK
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCHHHHHHHHHHHHH
VGQIETERHTGGNVLFYLSTQPSQYAEIAHGIGVAGMGKGNGWRRLVVEKPFGHDLASAR
HCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEECCCCCCEEEEEEECCCCCHHHHHH
ELSNRLHEVFDESDVYRIDHYLGKETVQNILAFRFGNGIFEPLWNRRYVNHVQITGAESI
HHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCHHC
GVEGRGAYYQEAGALDDMIQNHLLQVMATVAMEPSASFRANSVRDERSKLLRSIRPMTRD
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
EVLQNAVAGQYGPARIGGEDVPGFRQEQGVDPNSQTNTYAAVTFFVDNWRWAGVPFYVRT
HHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEEEEEECCEECCCCEEECC
GKRLAKRVSEIAIQFNSAPLHLFNQDSGGPSGDPGVNLLILRIQPEEGISLKFLSKRPGQ
HHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCC
GMTLRPVSMDFNYGSSFGERSPSAYETLLLDAIIGDPTLYTRQDMVEASWSVVEPIQNTW
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RETKFDFPNYPAGSWGPQAADVMLARRGHVWRKP
HHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLDLMPNENPFQDPLRFERQVPECVIVIFGANGDLTKRKLLPALYRLAYDRRLAAGFAVV
CCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEE
GISRTPLSDDQFRAKMRESVEQFSEDTKLDEEVWGAFARGLYYVAGDVADAGLYQRVSEK
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCHHHHHHHHHHHHH
VGQIETERHTGGNVLFYLSTQPSQYAEIAHGIGVAGMGKGNGWRRLVVEKPFGHDLASAR
HCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCEEECCCCCCEEEEEEECCCCCHHHHHH
ELSNRLHEVFDESDVYRIDHYLGKETVQNILAFRFGNGIFEPLWNRRYVNHVQITGAESI
HHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCHHC
GVEGRGAYYQEAGALDDMIQNHLLQVMATVAMEPSASFRANSVRDERSKLLRSIRPMTRD
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
EVLQNAVAGQYGPARIGGEDVPGFRQEQGVDPNSQTNTYAAVTFFVDNWRWAGVPFYVRT
HHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEEEEEECCEECCCCEEECC
GKRLAKRVSEIAIQFNSAPLHLFNQDSGGPSGDPGVNLLILRIQPEEGISLKFLSKRPGQ
HHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCC
GMTLRPVSMDFNYGSSFGERSPSAYETLLLDAIIGDPTLYTRQDMVEASWSVVEPIQNTW
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RETKFDFPNYPAGSWGPQAADVMLARRGHVWRKP
HHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]