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The map label for this gene is xylR [H]

Identifier: 116624256

GI number: 116624256

Start: 6498500

End: 6499354

Strand: Reverse

Name: xylR [H]

Synonym: Acid_5174

Alternate gene names: 116624256

Gene position: 6499354-6498500 (Counterclockwise)

Preceding gene: 116624257

Following gene: 116624255

Centisome position: 65.22

GC content: 63.98

Gene sequence:

>855_bases
ATGATTCTGGCGATCGATATCGGCGGCACCAAGTTCAGCATGGCGGTCTTCGAAGGCGAGCGCATGGTGCGGCGCGAATC
GCGCGCCACTAACGCGGAAGGAGGGCGGGCGTGGATGGTGGAGCGGATCGCCGAAATCTGCGGAGAGTGGCGGCGCGAGT
TTTGCCTGGAGCGCTGCGGGATCGGGTTCGGTGGCCCTGTCAATTTTTTCGCCCAGCGGGTGGTGTTCTCCACCCACGTC
GGCGGCTGGGATGATTTCGACCTGTGCGGTTTTGTGCAGCAGGCGGCCGGAGTTCCCGCGGTGATGGACAACGATGCCAA
TGCCGGCGCCATCGGCGAGGCCGAATTCGGGGCAGGCAAGGGTCATTCGCCGTTGTTCTATATGACACTTTCCACCGGCA
TTGGCGGGGGCATCTGGGAGGATGGGCGGGTTTGGCGCGGCGCCGATTCGTACGGCGGCGAAATCGGCCACATGACAATT
CGCCCCGAGGGTCCCGAATGCCTGTGCGGCGCGCGGGGCTGTTTCGAGCGCATGTGCTGCGGCCTATGGCTGCAGCGGGA
TTACGGCAAGCCGGCCAGCGAGCTGATGCTCGACGCCGAATTCGTCAGACGCTACGTGGTGGACCTGGCGCTCGGCTTGA
AGGCGGCGATCATGCTGCTCAATCCGCAGCGCATCGTAATCGGCGGGGGAATTACCAAGGCGGGCGACCGGTTGTTCGTT
CCCTTACGTGAAGAGCTGGGGAGGACCATTACGAAATGGTCTGCAGCCCGCGTTGACGTAGTCCCGGCGGCGCTCGGCGA
TGACAGTGTGTTGTACGGCGCACTCGCGATGGCTAGGGGGAACCCACTCCGGTAA

Upstream 100 bases:

>100_bases
CGATCGCGGCCAACCAGTGGAGCGCGCTGCCGATCAACGTGGACGAGGCGCGCGGGCGCGTCTGGGATTGGAAGGATGCT
CAATTTTTGCGAGGTTTGCA

Downstream 100 bases:

>100_bases
AGTACCGGGTCAATCTGCCAAGGAGTACTAACGATCTACGGCTTTAGACAACGCCGGGTTACTAGCGGAGTGCCACTAAC
CCAAATCAAATAGGACACTT

Product: ROK family protein

Products: ADP; D-glucose 6-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MILAIDIGGTKFSMAVFEGERMVRRESRATNAEGGRAWMVERIAEICGEWRREFCLERCGIGFGGPVNFFAQRVVFSTHV
GGWDDFDLCGFVQQAAGVPAVMDNDANAGAIGEAEFGAGKGHSPLFYMTLSTGIGGGIWEDGRVWRGADSYGGEIGHMTI
RPEGPECLCGARGCFERMCCGLWLQRDYGKPASELMLDAEFVRRYVVDLALGLKAAIMLLNPQRIVIGGGITKAGDRLFV
PLREELGRTITKWSAARVDVVPAALGDDSVLYGALAMARGNPLR

Sequences:

>Translated_284_residues
MILAIDIGGTKFSMAVFEGERMVRRESRATNAEGGRAWMVERIAEICGEWRREFCLERCGIGFGGPVNFFAQRVVFSTHV
GGWDDFDLCGFVQQAAGVPAVMDNDANAGAIGEAEFGAGKGHSPLFYMTLSTGIGGGIWEDGRVWRGADSYGGEIGHMTI
RPEGPECLCGARGCFERMCCGLWLQRDYGKPASELMLDAEFVRRYVVDLALGLKAAIMLLNPQRIVIGGGITKAGDRLFV
PLREELGRTITKWSAARVDVVPAALGDDSVLYGALAMARGNPLR
>Mature_284_residues
MILAIDIGGTKFSMAVFEGERMVRRESRATNAEGGRAWMVERIAEICGEWRREFCLERCGIGFGGPVNFFAQRVVFSTHV
GGWDDFDLCGFVQQAAGVPAVMDNDANAGAIGEAEFGAGKGHSPLFYMTLSTGIGGGIWEDGRVWRGADSYGGEIGHMTI
RPEGPECLCGARGCFERMCCGLWLQRDYGKPASELMLDAEFVRRYVVDLALGLKAAIMLLNPQRIVIGGGITKAGDRLFV
PLREELGRTITKWSAARVDVVPAALGDDSVLYGALAMARGNPLR

Specific function: Transcriptional repressor of xylose-utilizing enzymes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=204, Percent_Identity=31.3725490196078, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4885285, Length=204, Percent_Identity=31.3725490196078, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI298566315, Length=204, Percent_Identity=31.3725490196078, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI190014632, Length=204, Percent_Identity=31.3725490196078, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87081733, Length=308, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787878, Length=206, Percent_Identity=25.7281553398058, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1790522, Length=245, Percent_Identity=26.530612244898, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787363, Length=270, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: 2.7.1.2

Molecular weight: Translated: 30765; Mature: 30765

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILAIDIGGTKFSMAVFEGERMVRRESRATNAEGGRAWMVERIAEICGEWRREFCLERCG
CEEEEEECCCEEEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
IGFGGPVNFFAQRVVFSTHVGGWDDFDLCGFVQQAAGVPAVMDNDANAGAIGEAEFGAGK
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCC
GHSPLFYMTLSTGIGGGIWEDGRVWRGADSYGGEIGHMTIRPEGPECLCGARGCFERMCC
CCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCEECHHHHHHHHHH
GLWLQRDYGKPASELMLDAEFVRRYVVDLALGLKAAIMLLNPQRIVIGGGITKAGDRLFV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCEEEE
PLREELGRTITKWSAARVDVVPAALGDDSVLYGALAMARGNPLR
EHHHHCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MILAIDIGGTKFSMAVFEGERMVRRESRATNAEGGRAWMVERIAEICGEWRREFCLERCG
CEEEEEECCCEEEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
IGFGGPVNFFAQRVVFSTHVGGWDDFDLCGFVQQAAGVPAVMDNDANAGAIGEAEFGAGK
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCC
GHSPLFYMTLSTGIGGGIWEDGRVWRGADSYGGEIGHMTIRPEGPECLCGARGCFERMCC
CCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCEECHHHHHHHHHH
GLWLQRDYGKPASELMLDAEFVRRYVVDLALGLKAAIMLLNPQRIVIGGGITKAGDRLFV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCEEEE
PLREELGRTITKWSAARVDVVPAALGDDSVLYGALAMARGNPLR
EHHHHCCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; D-glucose

Specific reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2544559 [H]