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The map label for this gene is yngE [H]

Identifier: 116622972

GI number: 116622972

Start: 4909094

End: 4910647

Strand: Reverse

Name: yngE [H]

Synonym: Acid_3875

Alternate gene names: 116622972

Gene position: 4910647-4909094 (Counterclockwise)

Preceding gene: 116622973

Following gene: 116622971

Centisome position: 49.28

GC content: 65.25

Gene sequence:

>1554_bases
ATGCGCCATCTTTTCGAACAACTGGAGAAGCTTGCATCGCGCCTCCGCGAGGGCGGGGGTGCGGCGCGCATCGAGAAGCA
GCACAAGGCTGGAAAACTGACGGCGCGCGAACGCATCGCGGCGCTGCTGGACCCCGGATCGCCGCTGCTCGAGATCGGAT
TGCTGATCGCCTACGACCGCTATGACGGGCAGGCGCCGGCCGCCGGCGTGGTCACTTGCGTGGGCCGCATCGAAGGCCGT
CCCGCCGTGATCGTGGCCAATGACGCCACCGTGAAGGCCGGAGCCTGGTGGCCGGAAACGATCACCAAAATTCTGCGCGC
GCAGGAAATCGCGATGCGCAACCGCCTGCCCATCGTCTACATGGTAGATTCGGCGGGCGTCAATCTTCCCTATCAGGACA
GCATCTTCCCCGGTCAGTACGGCGCCGGCCGGATCTTCTATTACAACTCGGTGATGCGCCGCAAACTCCGCATTCCGCAG
ATCGCCGCCGTCATGGGCCCCTGCATCGCGGGAGGCGCTTATCTTCCGGCCTTGAGCGACGTCATCTTCATGGTGGAGGG
GACAAGCTTTATGGGGCTCGGAGGACCCAACCTGGTGAAGGGCGCTACCGGGCACGTGATCGATTCCGAACCGCTCGGCG
GCGCCCGCCTTCACACCTCGGTCAGCGGCGTGGCGCACTATATGCCGAAGGACGACGCGGAATGCCTGCGCATGATCCGC
GAGCGCTTTCGCCAGTTGCCTGCGCCGTCCCCCGCACCCACGGGCGCCACCGCGCCAGCGCGCGACGCTGCGCAGATTTA
CGGCGCGCTGCCCGCCGACCACCGCCTGCCGTACGAGATGGAGGATGTGATCTTCCGCATCTTCGACGCCGCCGATTATC
GCGAGTTCCAGCCAGAGATCGCGCCCGAGATGCTGTGTGCCAATGCGCGTCTTAACGGTCGTCCGGTGGCTGTCATCGCC
AACCGCCGCGGCTTTTTGAAGGCGCAGGGCAAGCCGCGCATCGGCGGCATCATCTATACGGAGAGCGCGCGCAAGGTGGC
GTACTTCGTAGAGAATGCGGAGCGCGCCGGCACTCCGCTGGTCTACCTGCAGGATGTTTCGGGTTTCATGGTGGGCCCGG
AGGCCGAGAAGGAAGGCATCATCCGCGCCGGCGCGGAGATGGTGGAGACCATGGCCTGCACCACCGTGCCTAAGATTGTG
CTCACGCTCAATCACGCCAGCGGGGCAGGGTATTACGCGATGGCCGGGCAGGGCTTCGATCCCAACTTTACCTTCAACTG
GCCGACCGCGCGCATCGGTGTGATGGAAGGCGATTCGGCGGTGGTCGCGCTGTTCTCTGCCGAGCTCGAAAAATACAAGG
GCGTCGAGATGCCGGAGGAATTGAAGGCCGCGGTGGAGCGCACGCGCGCCGATTACGAGCGCTGGCTGGACGCACGCTAT
GCCGCCGCGCGCGGCCACTGCGACGCCATCATCGATCCCCTGGGCACGCGCGAGACACTGGCATTCGCCCTGGAGGCATG
CATGCAACACGGTTGCGGAACGGAGCGGGCATGA

Upstream 100 bases:

>100_bases
ATCCTGGCGAAACCGCCGGAATCGGTATTCCTGGAGCCGACTGATTTCTCGCAGCTGAAATAACGGTTCAAATAACGTGG
ACGTCGCGCGCCAGGCGCAC

Downstream 100 bases:

>100_bases
TTCGCATCGCCAATGGCCAAGGCTTCTGGGGCGACTGGCTGGAAGCGCCCGTGCGCCTGGTGGAACAGGGTCCGCTGGAC
TATCTCGCGCTCGATTACCT

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MRHLFEQLEKLASRLREGGGAARIEKQHKAGKLTARERIAALLDPGSPLLEIGLLIAYDRYDGQAPAAGVVTCVGRIEGR
PAVIVANDATVKAGAWWPETITKILRAQEIAMRNRLPIVYMVDSAGVNLPYQDSIFPGQYGAGRIFYYNSVMRRKLRIPQ
IAAVMGPCIAGGAYLPALSDVIFMVEGTSFMGLGGPNLVKGATGHVIDSEPLGGARLHTSVSGVAHYMPKDDAECLRMIR
ERFRQLPAPSPAPTGATAPARDAAQIYGALPADHRLPYEMEDVIFRIFDAADYREFQPEIAPEMLCANARLNGRPVAVIA
NRRGFLKAQGKPRIGGIIYTESARKVAYFVENAERAGTPLVYLQDVSGFMVGPEAEKEGIIRAGAEMVETMACTTVPKIV
LTLNHASGAGYYAMAGQGFDPNFTFNWPTARIGVMEGDSAVVALFSAELEKYKGVEMPEELKAAVERTRADYERWLDARY
AAARGHCDAIIDPLGTRETLAFALEACMQHGCGTERA

Sequences:

>Translated_517_residues
MRHLFEQLEKLASRLREGGGAARIEKQHKAGKLTARERIAALLDPGSPLLEIGLLIAYDRYDGQAPAAGVVTCVGRIEGR
PAVIVANDATVKAGAWWPETITKILRAQEIAMRNRLPIVYMVDSAGVNLPYQDSIFPGQYGAGRIFYYNSVMRRKLRIPQ
IAAVMGPCIAGGAYLPALSDVIFMVEGTSFMGLGGPNLVKGATGHVIDSEPLGGARLHTSVSGVAHYMPKDDAECLRMIR
ERFRQLPAPSPAPTGATAPARDAAQIYGALPADHRLPYEMEDVIFRIFDAADYREFQPEIAPEMLCANARLNGRPVAVIA
NRRGFLKAQGKPRIGGIIYTESARKVAYFVENAERAGTPLVYLQDVSGFMVGPEAEKEGIIRAGAEMVETMACTTVPKIV
LTLNHASGAGYYAMAGQGFDPNFTFNWPTARIGVMEGDSAVVALFSAELEKYKGVEMPEELKAAVERTRADYERWLDARY
AAARGHCDAIIDPLGTRETLAFALEACMQHGCGTERA
>Mature_517_residues
MRHLFEQLEKLASRLREGGGAARIEKQHKAGKLTARERIAALLDPGSPLLEIGLLIAYDRYDGQAPAAGVVTCVGRIEGR
PAVIVANDATVKAGAWWPETITKILRAQEIAMRNRLPIVYMVDSAGVNLPYQDSIFPGQYGAGRIFYYNSVMRRKLRIPQ
IAAVMGPCIAGGAYLPALSDVIFMVEGTSFMGLGGPNLVKGATGHVIDSEPLGGARLHTSVSGVAHYMPKDDAECLRMIR
ERFRQLPAPSPAPTGATAPARDAAQIYGALPADHRLPYEMEDVIFRIFDAADYREFQPEIAPEMLCANARLNGRPVAVIA
NRRGFLKAQGKPRIGGIIYTESARKVAYFVENAERAGTPLVYLQDVSGFMVGPEAEKEGIIRAGAEMVETMACTTVPKIV
LTLNHASGAGYYAMAGQGFDPNFTFNWPTARIGVMEGDSAVVALFSAELEKYKGVEMPEELKAAVERTRADYERWLDARY
AAARGHCDAIIDPLGTRETLAFALEACMQHGCGTERA

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=518, Percent_Identity=39.1891891891892, Blast_Score=338, Evalue=9e-93,
Organism=Homo sapiens, GI119943100, Length=529, Percent_Identity=33.0812854442344, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI295821216, Length=549, Percent_Identity=32.6047358834244, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI310133460, Length=125, Percent_Identity=46.4, Blast_Score=102, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17552936, Length=519, Percent_Identity=39.4990366088632, Blast_Score=359, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI25147362, Length=492, Percent_Identity=33.739837398374, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI25147359, Length=492, Percent_Identity=33.739837398374, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24586065, Length=536, Percent_Identity=38.2462686567164, Blast_Score=353, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: NA

Molecular weight: Translated: 56148; Mature: 56148

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHLFEQLEKLASRLREGGGAARIEKQHKAGKLTARERIAALLDPGSPLLEIGLLIAYDR
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCHHHHEEEEEEEEC
YDGQAPAAGVVTCVGRIEGRPAVIVANDATVKAGAWWPETITKILRAQEIAMRNRLPIVY
CCCCCCCHHHHHHHHHCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEE
MVDSAGVNLPYQDSIFPGQYGAGRIFYYNSVMRRKLRIPQIAAVMGPCIAGGAYLPALSD
EECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHC
VIFMVEGTSFMGLGGPNLVKGATGHVIDSEPLGGARLHTSVSGVAHYMPKDDAECLRMIR
EEEEEECCEEEECCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
ERFRQLPAPSPAPTGATAPARDAAQIYGALPADHRLPYEMEDVIFRIFDAADYREFQPEI
HHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCCHH
APEMLCANARLNGRPVAVIANRRGFLKAQGKPRIGGIIYTESARKVAYFVENAERAGTPL
HHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCEEEEECCCCEEHHHHHHHHHCCCCE
VYLQDVSGFMVGPEAEKEGIIRAGAEMVETMACTTVPKIVLTLNHASGAGYYAMAGQGFD
EEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCC
PNFTFNWPTARIGVMEGDSAVVALFSAELEKYKGVEMPEELKAAVERTRADYERWLDARY
CCEEECCCCEEEEEEECCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AAARGHCDAIIDPLGTRETLAFALEACMQHGCGTERA
HHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRHLFEQLEKLASRLREGGGAARIEKQHKAGKLTARERIAALLDPGSPLLEIGLLIAYDR
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCHHHHEEEEEEEEC
YDGQAPAAGVVTCVGRIEGRPAVIVANDATVKAGAWWPETITKILRAQEIAMRNRLPIVY
CCCCCCCHHHHHHHHHCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEE
MVDSAGVNLPYQDSIFPGQYGAGRIFYYNSVMRRKLRIPQIAAVMGPCIAGGAYLPALSD
EECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHC
VIFMVEGTSFMGLGGPNLVKGATGHVIDSEPLGGARLHTSVSGVAHYMPKDDAECLRMIR
EEEEEECCEEEECCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
ERFRQLPAPSPAPTGATAPARDAAQIYGALPADHRLPYEMEDVIFRIFDAADYREFQPEI
HHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCCHH
APEMLCANARLNGRPVAVIANRRGFLKAQGKPRIGGIIYTESARKVAYFVENAERAGTPL
HHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCEEEEECCCCEEHHHHHHHHHCCCCE
VYLQDVSGFMVGPEAEKEGIIRAGAEMVETMACTTVPKIVLTLNHASGAGYYAMAGQGFD
EEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCC
PNFTFNWPTARIGVMEGDSAVVALFSAELEKYKGVEMPEELKAAVERTRADYERWLDARY
CCEEECCCCEEEEEEECCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AAARGHCDAIIDPLGTRETLAFALEACMQHGCGTERA
HHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]