Click here to switch to the map view.

The map label for this gene is tcmR [H]

Identifier: 116622225

GI number: 116622225

Start: 3954088

End: 3954711

Strand: Reverse

Name: tcmR [H]

Synonym: Acid_3118

Alternate gene names: 116622225

Gene position: 3954711-3954088 (Counterclockwise)

Preceding gene: 116622228

Following gene: 116622222

Centisome position: 39.68

GC content: 63.78

Gene sequence:

>624_bases
ATGAATTCGCAATCGTCGCAGCACTCCGCCAACACGCCCTCGCTGCAGATCCGCAAGCAGCAGTTGGTGCGAGACGCAAT
CTGGGATGCCGCGACGGACCTGTTCGCCGTGAAGGGTTTCGACGAGACCACGGTGGAGGACATTGCAGAAGCAGCGGGCG
TATCGCGGCGATCCTTCTTCCGCTACTTCGCCTCCAAGAACGACCTGATGGCGCATGGGATGGTGAATTACGGAGCCGAA
CTCACGGCCGCCATTGAAGCCTGCCCCGAGAAGGACTCGCTGGCCGAGGTCTTTCGGAAGACGGTGCTCCAGGTTGCCCG
GAAATCCGCCGCGAACCCTCGCGCGCGGATCATCCTGGCGATCGTGACCAAGTACCCGGCCGCGCGGGAGGCGGAGCTAT
CGCGGTTCGCCGAGGTGCAGGATCTGGTTGCGAAGGCGTTCGCCCGGCGCTGCAGGAAGCGCGGTGAAACCGAACTGACG
GCGCGGCTGCTGGCCGGACTGACGCTGCAGGTTACGGGAGTAACGGTGCGATGGTGGTTCGAGCAAGGCGAGCCGGAGAT
TCAAAGTGCGGTGGATGACGCACTCGCGACTCTGGAGCACCTGATTTGCCGCCGGCGGAAGTGA

Upstream 100 bases:

>100_bases
GTGCCATCGACGGGATTATATCGGCACTCAGTGCCATTGTCAACAGCTCACGCCACTCTTGCTCCCAAGCCGCAACACAT
GGTAACGTTGCGAAAGCGTC

Downstream 100 bases:

>100_bases
AGGTCCGCCGGCGGCGACAGGACAAAGTACTGTTCTACTGTTGGTCGTCGTCTCCTTCCTTGGCGCCGTGGAATGTGGCA
ATCGCGATACCGGAACGGCC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MNSQSSQHSANTPSLQIRKQQLVRDAIWDAATDLFAVKGFDETTVEDIAEAAGVSRRSFFRYFASKNDLMAHGMVNYGAE
LTAAIEACPEKDSLAEVFRKTVLQVARKSAANPRARIILAIVTKYPAAREAELSRFAEVQDLVAKAFARRCRKRGETELT
ARLLAGLTLQVTGVTVRWWFEQGEPEIQSAVDDALATLEHLICRRRK

Sequences:

>Translated_207_residues
MNSQSSQHSANTPSLQIRKQQLVRDAIWDAATDLFAVKGFDETTVEDIAEAAGVSRRSFFRYFASKNDLMAHGMVNYGAE
LTAAIEACPEKDSLAEVFRKTVLQVARKSAANPRARIILAIVTKYPAAREAELSRFAEVQDLVAKAFARRCRKRGETELT
ARLLAGLTLQVTGVTVRWWFEQGEPEIQSAVDDALATLEHLICRRRK
>Mature_207_residues
MNSQSSQHSANTPSLQIRKQQLVRDAIWDAATDLFAVKGFDETTVEDIAEAAGVSRRSFFRYFASKNDLMAHGMVNYGAE
LTAAIEACPEKDSLAEVFRKTVLQVARKSAANPRARIILAIVTKYPAAREAELSRFAEVQDLVAKAFARRCRKRGETELT
ARLLAGLTLQVTGVTVRWWFEQGEPEIQSAVDDALATLEHLICRRRK

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23098; Mature: 23098

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSQSSQHSANTPSLQIRKQQLVRDAIWDAATDLFAVKGFDETTVEDIAEAAGVSRRSFF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHH
RYFASKNDLMAHGMVNYGAELTAAIEACPEKDSLAEVFRKTVLQVARKSAANPRARIILA
HHHHCCCCHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IVTKYPAAREAELSRFAEVQDLVAKAFARRCRKRGETELTARLLAGLTLQVTGVTVRWWF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEEEEEEEEE
EQGEPEIQSAVDDALATLEHLICRRRK
CCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSQSSQHSANTPSLQIRKQQLVRDAIWDAATDLFAVKGFDETTVEDIAEAAGVSRRSFF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHH
RYFASKNDLMAHGMVNYGAELTAAIEACPEKDSLAEVFRKTVLQVARKSAANPRARIILA
HHHHCCCCHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IVTKYPAAREAELSRFAEVQDLVAKAFARRCRKRGETELTARLLAGLTLQVTGVTVRWWF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEEEEEEEEE
EQGEPEIQSAVDDALATLEHLICRRRK
CCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]