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The map label for this gene is copA [H]

Identifier: 116622170

GI number: 116622170

Start: 3860327

End: 3861799

Strand: Reverse

Name: copA [H]

Synonym: Acid_3062

Alternate gene names: 116622170

Gene position: 3861799-3860327 (Counterclockwise)

Preceding gene: 116622175

Following gene: 116622169

Centisome position: 38.75

GC content: 63.61

Gene sequence:

>1473_bases
ATGCCCAGCCCAACCTCCCGCCCTATCCATATAGACCGCCGCGATTTCCTGAAACTCGCCGGCGCGGCAGCGGCCGCGGC
ACCGCTGGCGGGGCAGGAAATGCCGATGCCGGGGCACGCGGCGCCGGCGGCTGCGCGCACCAACGAGATCTCCGGAACAG
TATTCAATCTCGAGATCGCGCCGGTGACCGTCGAACTTGCGCCGAACCGGATCGTCAGCACGATCGGCTACAACGGCATG
TCGCCGGGACCCCTCCTGCGGATGAAGGAAGGCGCGCCGGTCACGGTCAACGTAGTCAACAAGACCGATACGCCTGAGTA
CGTCCATTTTCACGGGTTGCTGATTCCAGCGGACGTGGATGGTTCCGAAGAAGAAGGCACGCCGCCGGTCCCGCCGCACG
GCACCCGCAGCTATAAATTCACGCCGACGCCCGCCGGGACGCGCTGGTATCACACGCATGCCATGTCGATGGACGATCTG
CACCGCGGTTCATACACCGGACAGTTCGGATTTCTGATCGTGGAGGGCGGCGCCAACCCGGGCAACTACGATCAGGAGCA
TTATCTGGCGCTGCGTGACTGGGAGCCGTACTTCACCACGCAATACATGGACACGGACGATCTCGACCCTTCGGGGCCGA
AGCCGGAGAAGCCCGCGGTGCTCGATACGCGGCCGCCCGGGCTCGAGGTGGCGGCCGACCTGTATTCGATCAACGACAAA
GCTCTGGGATCGGGCGAACCCATCCGTGTGCGTGCGGGCGAGCGTGTCATGTTCCATTTTCTGAACGCGAGCGCGATCGA
GAACCGGCACCTGGCGCTGCCCGGGCACAAATTCAACATCGTAGGACTCGATGGCAATCCGGTACCGCGAAGCGCAGCGG
TAGACGTGTTGATGCTGGGTCCGGGCGAGCGCATCGATGCCTGGGTGACGATGAATCAGCCGGGCGTCTGGGTGATGGGT
GCGCCGGAAGATATGGTGCGCGACGGCGGGCTCGGCGTGGTAATCGAGTACGCCAACCAGCGGCGCAGTCCGCAATGGAT
GCCGCCGCCGCAGTCCGGGTGGGACTACACCATTTTCGGGAAGCCGGCCTCCGGACCGGCGCCCTCCGAGCATTTGGAGA
TGATCTTTGAGAAGGTGCCGCGCGGCGCCGGAAAGTTCAATCTGTTCACGGTGAACGGCGCGCCTTATCCGCACGATCGC
GAGTTTGTGTTGAAACAGGGCGCCCGCTACCGCCTGACCTTCCGCAACCGCACGGACGATTCGCATCCCCTGCACCTCCA
CCGGCATCAGTTCGAGATCGCCGAGATCTACGGAAAACCCACCGCGGGGATCATCAAGGATACAGTGGTCGCCCCCTCGT
ATGGCCGCGTGAGCGTCGATTTCACCGCCGACCAGCCAGGTCCGGCGCTGTTTCACTGCCATATCCAGCACCACATGGAC
TACGGCTTCAAGGCACTCCTGAAGTACGCCTGA

Upstream 100 bases:

>100_bases
CAAGCAGGGGCCACGCCAGTTTCATGCTCCGAGCGCCTTTGTTATCCTGAAGCGTATCACGAACGGCCCTCGGGACGAAG
ATCCCTGCGAATCTTTTTCG

Downstream 100 bases:

>100_bases
GGAAGAACCCGGAGTTTTCTTCGTTCTGGATTTTTCGACACGCTGCCTCTTCATCATTCCTGTGTATACTCTCAGAAAAT
CAGCATACGGAGGTGTCAGA

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MPSPTSRPIHIDRRDFLKLAGAAAAAAPLAGQEMPMPGHAAPAAARTNEISGTVFNLEIAPVTVELAPNRIVSTIGYNGM
SPGPLLRMKEGAPVTVNVVNKTDTPEYVHFHGLLIPADVDGSEEEGTPPVPPHGTRSYKFTPTPAGTRWYHTHAMSMDDL
HRGSYTGQFGFLIVEGGANPGNYDQEHYLALRDWEPYFTTQYMDTDDLDPSGPKPEKPAVLDTRPPGLEVAADLYSINDK
ALGSGEPIRVRAGERVMFHFLNASAIENRHLALPGHKFNIVGLDGNPVPRSAAVDVLMLGPGERIDAWVTMNQPGVWVMG
APEDMVRDGGLGVVIEYANQRRSPQWMPPPQSGWDYTIFGKPASGPAPSEHLEMIFEKVPRGAGKFNLFTVNGAPYPHDR
EFVLKQGARYRLTFRNRTDDSHPLHLHRHQFEIAEIYGKPTAGIIKDTVVAPSYGRVSVDFTADQPGPALFHCHIQHHMD
YGFKALLKYA

Sequences:

>Translated_490_residues
MPSPTSRPIHIDRRDFLKLAGAAAAAAPLAGQEMPMPGHAAPAAARTNEISGTVFNLEIAPVTVELAPNRIVSTIGYNGM
SPGPLLRMKEGAPVTVNVVNKTDTPEYVHFHGLLIPADVDGSEEEGTPPVPPHGTRSYKFTPTPAGTRWYHTHAMSMDDL
HRGSYTGQFGFLIVEGGANPGNYDQEHYLALRDWEPYFTTQYMDTDDLDPSGPKPEKPAVLDTRPPGLEVAADLYSINDK
ALGSGEPIRVRAGERVMFHFLNASAIENRHLALPGHKFNIVGLDGNPVPRSAAVDVLMLGPGERIDAWVTMNQPGVWVMG
APEDMVRDGGLGVVIEYANQRRSPQWMPPPQSGWDYTIFGKPASGPAPSEHLEMIFEKVPRGAGKFNLFTVNGAPYPHDR
EFVLKQGARYRLTFRNRTDDSHPLHLHRHQFEIAEIYGKPTAGIIKDTVVAPSYGRVSVDFTADQPGPALFHCHIQHHMD
YGFKALLKYA
>Mature_489_residues
PSPTSRPIHIDRRDFLKLAGAAAAAAPLAGQEMPMPGHAAPAAARTNEISGTVFNLEIAPVTVELAPNRIVSTIGYNGMS
PGPLLRMKEGAPVTVNVVNKTDTPEYVHFHGLLIPADVDGSEEEGTPPVPPHGTRSYKFTPTPAGTRWYHTHAMSMDDLH
RGSYTGQFGFLIVEGGANPGNYDQEHYLALRDWEPYFTTQYMDTDDLDPSGPKPEKPAVLDTRPPGLEVAADLYSINDKA
LGSGEPIRVRAGERVMFHFLNASAIENRHLALPGHKFNIVGLDGNPVPRSAAVDVLMLGPGERIDAWVTMNQPGVWVMGA
PEDMVRDGGLGVVIEYANQRRSPQWMPPPQSGWDYTIFGKPASGPAPSEHLEMIFEKVPRGAGKFNLFTVNGAPYPHDRE
FVLKQGARYRLTFRNRTDDSHPLHLHRHQFEIAEIYGKPTAGIIKDTVVAPSYGRVSVDFTADQPGPALFHCHIQHHMDY
GFKALLKYA

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=181, Percent_Identity=30.939226519337, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321067, Length=247, Percent_Identity=26.7206477732794, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 53749; Mature: 53618

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPTSRPIHIDRRDFLKLAGAAAAAAPLAGQEMPMPGHAAPAAARTNEISGTVFNLEIA
CCCCCCCCEEECHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
PVTVELAPNRIVSTIGYNGMSPGPLLRMKEGAPVTVNVVNKTDTPEYVHFHGLLIPADVD
EEEEEECCCCEEHHHCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEEECCCC
GSEEEGTPPVPPHGTRSYKFTPTPAGTRWYHTHAMSMDDLHRGSYTGQFGFLIVEGGANP
CCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEECCHHHHCCCCCCCCEEEEEEECCCCC
GNYDQEHYLALRDWEPYFTTQYMDTDDLDPSGPKPEKPAVLDTRPPGLEVAADLYSINDK
CCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEEECCCC
ALGSGEPIRVRAGERVMFHFLNASAIENRHLALPGHKFNIVGLDGNPVPRSAAVDVLMLG
CCCCCCCEEEECCCEEEEEEECCHHCCCCEEECCCCEEEEEEECCCCCCCHHHEEEEEEC
PGERIDAWVTMNQPGVWVMGAPEDMVRDGGLGVVIEYANQRRSPQWMPPPQSGWDYTIFG
CCCCEEEEEEECCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEC
KPASGPAPSEHLEMIFEKVPRGAGKFNLFTVNGAPYPHDREFVLKQGARYRLTFRNRTDD
CCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCCC
SHPLHLHRHQFEIAEIYGKPTAGIIKDTVVAPSYGRVSVDFTADQPGPALFHCHIQHHMD
CCCEEEECCEEEEEHHCCCCCCCHHHHEEECCCCCEEEEEEECCCCCCEEEEEEEEECCC
YGFKALLKYA
CCHHHHHHCC
>Mature Secondary Structure 
PSPTSRPIHIDRRDFLKLAGAAAAAAPLAGQEMPMPGHAAPAAARTNEISGTVFNLEIA
CCCCCCCEEECHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
PVTVELAPNRIVSTIGYNGMSPGPLLRMKEGAPVTVNVVNKTDTPEYVHFHGLLIPADVD
EEEEEECCCCEEHHHCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEEECCCC
GSEEEGTPPVPPHGTRSYKFTPTPAGTRWYHTHAMSMDDLHRGSYTGQFGFLIVEGGANP
CCCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEECCHHHHCCCCCCCCEEEEEEECCCCC
GNYDQEHYLALRDWEPYFTTQYMDTDDLDPSGPKPEKPAVLDTRPPGLEVAADLYSINDK
CCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEEECCCC
ALGSGEPIRVRAGERVMFHFLNASAIENRHLALPGHKFNIVGLDGNPVPRSAAVDVLMLG
CCCCCCCEEEECCCEEEEEEECCHHCCCCEEECCCCEEEEEEECCCCCCCHHHEEEEEEC
PGERIDAWVTMNQPGVWVMGAPEDMVRDGGLGVVIEYANQRRSPQWMPPPQSGWDYTIFG
CCCCEEEEEEECCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEC
KPASGPAPSEHLEMIFEKVPRGAGKFNLFTVNGAPYPHDREFVLKQGARYRLTFRNRTDD
CCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCCC
SHPLHLHRHQFEIAEIYGKPTAGIIKDTVVAPSYGRVSVDFTADQPGPALFHCHIQHHMD
CCCEEEECCEEEEEHHCCCCCCCHHHHEEECCCCCEEEEEEECCCCCCEEEEEEEEECCC
YGFKALLKYA
CCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]