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The map label for this gene is fdh [H]

Identifier: 116622108

GI number: 116622108

Start: 3789768

End: 3790937

Strand: Reverse

Name: fdh [H]

Synonym: Acid_2995

Alternate gene names: 116622108

Gene position: 3790937-3789768 (Counterclockwise)

Preceding gene: 116622109

Following gene: 116622099

Centisome position: 38.04

GC content: 58.72

Gene sequence:

>1170_bases
ATGAAAGCGAATTGTTGGCGAGGCAAAAAGAAGATGGAGGTCGAACAGGTGCCCGATCCGAAGATCCTCAACTCGCAGGA
CGCGATCGTGAAAATTACGAGCACGGCGATCTGCGGCTCCGACCTTCACCTCTATAACGGGTTCGTTCCGTCGATGCAGG
ACGGCGATATTGTGGGCCACGAGTTCATGGGTGAAGTCATGGAAGTCGGGAAAGACGTCGGCAAACTGAAAGTAGGCGAC
CGGGTAGTCGTGCCGTTTCCGATTTCCTGCGGGAAGTGTTTCTTCTGCGAAAAACAAATGTATTCTCTCTGCGAGAATTC
CAACCCGAATGCCTGGCTGGCGGAGAAGCTGTGGGGACACTCGCCGGCGGGTCTCTTTGGGTATTCCCACCTGCTCGGTG
GATTCGCGGGTGGGCAGGCCGAATACGCGCGCGTGCCATTCGCGGATGTGGGCCCCATCAGAATCGAAAACGGCTTCACC
GACGAGCAGGTTCTGTTCCTGTCCGATATCTTTCCCACCGGGTATATGGCAGCCGAAGCTTGCGACATCCAGCCCGGCGA
TACCATCGCCGTCTGGGGCTGCGGACCGGTAGGGTTGTTCGCTATCAAGAGTGCGTTCCTGCTTGGCGCCGAGCGTGTCA
TCGCGATTGACCGCTTTCCCGAGCGGCTGAAAATGGCGCGAGAGAAGTGCGGCGCCGTCACTCTGAATTACGAACATGTG
GACGTGCTCGATACACTCAAGGAGATGACCGGAGGCCGCGGTCCCGATTCCTGCATCGACTCCGTCGGTATGGAGGCGCA
CGGCCATGGCGCGATGTACGCATACGATCGCGCCAAGCAGGCCCTGATGCTGGAGTCGGACCGCCCCATCGCGCTGCGGG
AGGCTATCATGGCCTGCCGCAACGGAGGGACAGTATCGGTGCCCGGCGTATATGGCGGGCTGGTGGACAAGCTGCCCATG
GGCTCTGTGATGAACCGGTCCCTTGTGATCAAAACTGGCCAGACGCACGTGCAACGCTACTTGCGGCCGCTTCTACAGAG
GATCGAAAACGGCGAGATCGATCCCAGCTTCGTGGTAACTCACCGGCTGCCGCTCGACGAAGCGCCCAAGGCTTACGACA
TGTTCTTGAACAAAACGGATGATTGCATCAAGGTCGTGCTCAAGCCATAG

Upstream 100 bases:

>100_bases
GGAGACGGGAGAGGCGATCACCACAGAAGGGCAACCGGCCGGCCGTCAAGACGGCACCACTTGGCTGGATAGCATTGCAA
AATAACGAGGAGGAGAAATC

Downstream 100 bases:

>100_bases
CGGCGGAGCCTGACGTCCCGGGGAAACAAGTCGTCAGGTCTTCACTGGCTTGCCGAGCCCAAACCTCTTCGTTGTGAGAT
CGATCATCGCATCCTCGATT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKANCWRGKKKMEVEQVPDPKILNSQDAIVKITSTAICGSDLHLYNGFVPSMQDGDIVGHEFMGEVMEVGKDVGKLKVGD
RVVVPFPISCGKCFFCEKQMYSLCENSNPNAWLAEKLWGHSPAGLFGYSHLLGGFAGGQAEYARVPFADVGPIRIENGFT
DEQVLFLSDIFPTGYMAAEACDIQPGDTIAVWGCGPVGLFAIKSAFLLGAERVIAIDRFPERLKMAREKCGAVTLNYEHV
DVLDTLKEMTGGRGPDSCIDSVGMEAHGHGAMYAYDRAKQALMLESDRPIALREAIMACRNGGTVSVPGVYGGLVDKLPM
GSVMNRSLVIKTGQTHVQRYLRPLLQRIENGEIDPSFVVTHRLPLDEAPKAYDMFLNKTDDCIKVVLKP

Sequences:

>Translated_389_residues
MKANCWRGKKKMEVEQVPDPKILNSQDAIVKITSTAICGSDLHLYNGFVPSMQDGDIVGHEFMGEVMEVGKDVGKLKVGD
RVVVPFPISCGKCFFCEKQMYSLCENSNPNAWLAEKLWGHSPAGLFGYSHLLGGFAGGQAEYARVPFADVGPIRIENGFT
DEQVLFLSDIFPTGYMAAEACDIQPGDTIAVWGCGPVGLFAIKSAFLLGAERVIAIDRFPERLKMAREKCGAVTLNYEHV
DVLDTLKEMTGGRGPDSCIDSVGMEAHGHGAMYAYDRAKQALMLESDRPIALREAIMACRNGGTVSVPGVYGGLVDKLPM
GSVMNRSLVIKTGQTHVQRYLRPLLQRIENGEIDPSFVVTHRLPLDEAPKAYDMFLNKTDDCIKVVLKP
>Mature_389_residues
MKANCWRGKKKMEVEQVPDPKILNSQDAIVKITSTAICGSDLHLYNGFVPSMQDGDIVGHEFMGEVMEVGKDVGKLKVGD
RVVVPFPISCGKCFFCEKQMYSLCENSNPNAWLAEKLWGHSPAGLFGYSHLLGGFAGGQAEYARVPFADVGPIRIENGFT
DEQVLFLSDIFPTGYMAAEACDIQPGDTIAVWGCGPVGLFAIKSAFLLGAERVIAIDRFPERLKMAREKCGAVTLNYEHV
DVLDTLKEMTGGRGPDSCIDSVGMEAHGHGAMYAYDRAKQALMLESDRPIALREAIMACRNGGTVSVPGVYGGLVDKLPM
GSVMNRSLVIKTGQTHVQRYLRPLLQRIENGEIDPSFVVTHRLPLDEAPKAYDMFLNKTDDCIKVVLKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=388, Percent_Identity=25.5154639175258, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=400, Percent_Identity=26.25, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI4501929, Length=268, Percent_Identity=30.2238805970149, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI34577061, Length=267, Percent_Identity=29.2134831460674, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI156523966, Length=380, Percent_Identity=25.2631578947368, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI4501933, Length=267, Percent_Identity=28.8389513108614, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI4501939, Length=255, Percent_Identity=28.6274509803922, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI71743840, Length=255, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI262073058, Length=255, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=47.9591836734694, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1790045, Length=372, Percent_Identity=26.3440860215054, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788073, Length=386, Percent_Identity=24.3523316062176, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788075, Length=381, Percent_Identity=26.246719160105, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787863, Length=376, Percent_Identity=24.2021276595745, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI226510992, Length=372, Percent_Identity=24.4623655913978, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082125, Length=382, Percent_Identity=24.869109947644, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081918, Length=231, Percent_Identity=32.9004329004329, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790718, Length=377, Percent_Identity=23.342175066313, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786552, Length=385, Percent_Identity=27.012987012987, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788407, Length=221, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=393, Percent_Identity=24.9363867684478, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=233, Percent_Identity=30.4721030042918, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=235, Percent_Identity=30.2127659574468, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=206, Percent_Identity=29.126213592233, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=405, Percent_Identity=28.3950617283951, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=428, Percent_Identity=23.1308411214953, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=391, Percent_Identity=25.0639386189258, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=374, Percent_Identity=24.5989304812834, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17137530, Length=388, Percent_Identity=25.7731958762887, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17737895, Length=393, Percent_Identity=26.2086513994911, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42571; Mature: 42571

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKANCWRGKKKMEVEQVPDPKILNSQDAIVKITSTAICGSDLHLYNGFVPSMQDGDIVGH
CCCCCCCCCCCCCHHCCCCCCCCCCCCCEEEEEEHEECCCCCHHHCCCCCCCCCCCEECH
EFMGEVMEVGKDVGKLKVGDRVVVPFPISCGKCFFCEKQMYSLCENSNPNAWLAEKLWGH
HHHHHHHHHHHHHCCEEECCEEEEECCCCCCCEEEEHHHHHHHHCCCCCCCCHHHHHCCC
SPAGLFGYSHLLGGFAGGQAEYARVPFADVGPIRIENGFTDEQVLFLSDIFPTGYMAAEA
CCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHC
CDIQPGDTIAVWGCGPVGLFAIKSAFLLGAERVIAIDRFPERLKMAREKCGAVTLNYEHV
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCEEEEECCHH
DVLDTLKEMTGGRGPDSCIDSVGMEAHGHGAMYAYDRAKQALMLESDRPIALREAIMACR
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEHHHHHHEEEECCCCCHHHHHHHHHHC
NGGTVSVPGVYGGLVDKLPMGSVMNRSLVIKTGQTHVQRYLRPLLQRIENGEIDPSFVVT
CCCEEECCCHHHHHHHHCCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEE
HRLPLDEAPKAYDMFLNKTDDCIKVVLKP
EECCCCCCCHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKANCWRGKKKMEVEQVPDPKILNSQDAIVKITSTAICGSDLHLYNGFVPSMQDGDIVGH
CCCCCCCCCCCCCHHCCCCCCCCCCCCCEEEEEEHEECCCCCHHHCCCCCCCCCCCEECH
EFMGEVMEVGKDVGKLKVGDRVVVPFPISCGKCFFCEKQMYSLCENSNPNAWLAEKLWGH
HHHHHHHHHHHHHCCEEECCEEEEECCCCCCCEEEEHHHHHHHHCCCCCCCCHHHHHCCC
SPAGLFGYSHLLGGFAGGQAEYARVPFADVGPIRIENGFTDEQVLFLSDIFPTGYMAAEA
CCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCHHHHC
CDIQPGDTIAVWGCGPVGLFAIKSAFLLGAERVIAIDRFPERLKMAREKCGAVTLNYEHV
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCEEEEECCHH
DVLDTLKEMTGGRGPDSCIDSVGMEAHGHGAMYAYDRAKQALMLESDRPIALREAIMACR
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEHHHHHHEEEECCCCCHHHHHHHHHHC
NGGTVSVPGVYGGLVDKLPMGSVMNRSLVIKTGQTHVQRYLRPLLQRIENGEIDPSFVVT
CCCEEECCCHHHHHHHHCCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEE
HRLPLDEAPKAYDMFLNKTDDCIKVVLKP
EECCCCCCCHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]