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The map label for this gene is malS [H]

Identifier: 116622067

GI number: 116622067

Start: 3733334

End: 3735067

Strand: Reverse

Name: malS [H]

Synonym: Acid_2954

Alternate gene names: 116622067

Gene position: 3735067-3733334 (Counterclockwise)

Preceding gene: 116622068

Following gene: 116622066

Centisome position: 37.48

GC content: 60.61

Gene sequence:

>1734_bases
ATGCGCCAGAGTGTCATACCGATCTTTGTACCCGTCACGAAGCCCCGGCCCCTTGAGTGTCGTTCCTATCAAACCAAGTG
TCGAGGGGTGGCGGTCCTGAATTCGCCCATGCTGAACAAAGGAACGGCGTTTACCTCAAAGGAGCGGAAAGAGCTGGGTC
TGACAGGCCTGCTCCCACCCGAAATCAGCACGCTCGGCACCCAGGTAAAATTGGCATATATCCAATATGACCGCCTGCCG
GATACATTGGCCAAGAACACCTACCTGACTACTCTGCACGCACACAACGAAGTGCTGTTTTACCGCCTCTTCTCAGAACA
CCTGCGTGAGATGATTCCAGTTCTCGACGATGCGACGCTGAGTCTGGCCGCACAGCGCAACCACCATGAGTGCGGTCAGT
CGCGAGGCGTGTACCTCTCGATTGACCACATCGACGCTATGGAAGAAGCGTTTGCCAATCTGGGCGCGGACGCCGGCGAC
ATCGACCTGATCCTGACTACCGACGGCGAGCAGGTACGGGGTGTCGGCGATGCAGGCATGAGCGGCATCGAAAGGTCTCT
CGGCAAACTCGCAGTCTATACGGCCGCCGGCGGAATCAATCCGAATCGGGCAATTTCCGTGGTGCTCGACGTCGGTACCG
ATCGGCAAGATCTCCTCGACGATCCCACGTACATCGGCAATCGGCATCCCCGAATCCGCGGGAAGCGCTACGATGCCTTC
CTGGAATCCTATGTAACGACCACTACGCGGCTGTTTCCGCACGCGATGCTTCATTGGGAGAACTTCGCTCCTGGGAACGG
ACGCCGGCTTCTCGAAAAATACGGCGGGCAGGTATGCACCTTCAATGACGATATGCAGGGTACCGGCGCGATCACCCTGG
CAGCGGCGATCTCCGCGGTCCGGATCTGCGGAACGCCTCTCCGCAATCAGCGGGTGGTTATCTTGGGCGCCGGGACTGCG
GGCGTTGGCATTGCAGATCAGATCTGCGACGCCATGGCGCGTGAGGGTCTCTCCCGGCAGGAGGCGGTGCGCCAGTTCTG
GTTTGTAGACCGGCAAGGCTTGCTTACCAGCAACATGACGGGCCAACTACGCGACCACCAGGTAACCTTCGCACGGCCGG
ATGTCGAGAGCAGAGGCTGGAAGCAGCTTCACGGGGGAGGCATCGGTCTCGCCGAGGTAGTGCGGCAAGTGAAACCCACC
ATGCTGATTGGCGCATCATCGTCGTCCGGCAGTTTCACGGAACCCATCATCAGGCAGATGGCGGCGCATACCGCCCGGCC
GATCATCTTCGTGCTTTCCACGCCGCCGGTGCGGGCGGAAGCGAATCCTGCCGACTTGATTGCGTGGACGGCCGGGCGCG
CGTTGATTGCGACTGGCAGCCTGTTTGCACCGGTCACGTACAGGGGCTTGACCTATGTGGTCGCGCAATTGAACAACGCG
ATGGTTTACCCGGGACTGAGTCTCGGCGCGGTAGTAGCACGTGCCCGCAGGATCAGCGAAGGGATGTTTGAGGCGGCGGC
CGGCGCGGTGTCGAGCCTGGTAACAGTGCGCCATCCAGGGGCATCGCTGCTGCCCCATATCGACGACCTGAGTTCGGTGT
CAATGACGGTGGCCGCCGCCGTGGCCGAAGCCGCGGTTTCGGAAGGCCTCTCACGAGCGCCGATCGATGATATTGTTCAA
CAGGTGCGAGATGCGATGTGGCAGCCCGAGTACCACGAGATCCAGGCATCATGA

Upstream 100 bases:

>100_bases
GCGCACGGCCGCAAGACGGATACAGTAATCCCTTTGCGATTTCTCGCGCGGCCCGCCTTCACCGGCGAGCCGCGCGAAGG
TCCGTTTTAGGAGATTCAGC

Downstream 100 bases:

>100_bases
ACATAGTCACGGCGAGTCTGCTGCCTTTGTTACTGGTGGTGGGGCCTACCGGGGCGCAGGACACGACGCCATTTCATCTT
TCGGTCAACGTCGACCTGGT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MRQSVIPIFVPVTKPRPLECRSYQTKCRGVAVLNSPMLNKGTAFTSKERKELGLTGLLPPEISTLGTQVKLAYIQYDRLP
DTLAKNTYLTTLHAHNEVLFYRLFSEHLREMIPVLDDATLSLAAQRNHHECGQSRGVYLSIDHIDAMEEAFANLGADAGD
IDLILTTDGEQVRGVGDAGMSGIERSLGKLAVYTAAGGINPNRAISVVLDVGTDRQDLLDDPTYIGNRHPRIRGKRYDAF
LESYVTTTTRLFPHAMLHWENFAPGNGRRLLEKYGGQVCTFNDDMQGTGAITLAAAISAVRICGTPLRNQRVVILGAGTA
GVGIADQICDAMAREGLSRQEAVRQFWFVDRQGLLTSNMTGQLRDHQVTFARPDVESRGWKQLHGGGIGLAEVVRQVKPT
MLIGASSSSGSFTEPIIRQMAAHTARPIIFVLSTPPVRAEANPADLIAWTAGRALIATGSLFAPVTYRGLTYVVAQLNNA
MVYPGLSLGAVVARARRISEGMFEAAAGAVSSLVTVRHPGASLLPHIDDLSSVSMTVAAAVAEAAVSEGLSRAPIDDIVQ
QVRDAMWQPEYHEIQAS

Sequences:

>Translated_577_residues
MRQSVIPIFVPVTKPRPLECRSYQTKCRGVAVLNSPMLNKGTAFTSKERKELGLTGLLPPEISTLGTQVKLAYIQYDRLP
DTLAKNTYLTTLHAHNEVLFYRLFSEHLREMIPVLDDATLSLAAQRNHHECGQSRGVYLSIDHIDAMEEAFANLGADAGD
IDLILTTDGEQVRGVGDAGMSGIERSLGKLAVYTAAGGINPNRAISVVLDVGTDRQDLLDDPTYIGNRHPRIRGKRYDAF
LESYVTTTTRLFPHAMLHWENFAPGNGRRLLEKYGGQVCTFNDDMQGTGAITLAAAISAVRICGTPLRNQRVVILGAGTA
GVGIADQICDAMAREGLSRQEAVRQFWFVDRQGLLTSNMTGQLRDHQVTFARPDVESRGWKQLHGGGIGLAEVVRQVKPT
MLIGASSSSGSFTEPIIRQMAAHTARPIIFVLSTPPVRAEANPADLIAWTAGRALIATGSLFAPVTYRGLTYVVAQLNNA
MVYPGLSLGAVVARARRISEGMFEAAAGAVSSLVTVRHPGASLLPHIDDLSSVSMTVAAAVAEAAVSEGLSRAPIDDIVQ
QVRDAMWQPEYHEIQAS
>Mature_577_residues
MRQSVIPIFVPVTKPRPLECRSYQTKCRGVAVLNSPMLNKGTAFTSKERKELGLTGLLPPEISTLGTQVKLAYIQYDRLP
DTLAKNTYLTTLHAHNEVLFYRLFSEHLREMIPVLDDATLSLAAQRNHHECGQSRGVYLSIDHIDAMEEAFANLGADAGD
IDLILTTDGEQVRGVGDAGMSGIERSLGKLAVYTAAGGINPNRAISVVLDVGTDRQDLLDDPTYIGNRHPRIRGKRYDAF
LESYVTTTTRLFPHAMLHWENFAPGNGRRLLEKYGGQVCTFNDDMQGTGAITLAAAISAVRICGTPLRNQRVVILGAGTA
GVGIADQICDAMAREGLSRQEAVRQFWFVDRQGLLTSNMTGQLRDHQVTFARPDVESRGWKQLHGGGIGLAEVVRQVKPT
MLIGASSSSGSFTEPIIRQMAAHTARPIIFVLSTPPVRAEANPADLIAWTAGRALIATGSLFAPVTYRGLTYVVAQLNNA
MVYPGLSLGAVVARARRISEGMFEAAAGAVSSLVTVRHPGASLLPHIDDLSSVSMTVAAAVAEAAVSEGLSRAPIDDIVQ
QVRDAMWQPEYHEIQAS

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=562, Percent_Identity=34.8754448398576, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI62420882, Length=566, Percent_Identity=36.7491166077738, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI62420880, Length=566, Percent_Identity=36.7491166077738, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI239049447, Length=566, Percent_Identity=36.7491166077738, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI4505145, Length=565, Percent_Identity=32.9203539823009, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI270265879, Length=476, Percent_Identity=34.0336134453782, Blast_Score=286, Evalue=5e-77,
Organism=Escherichia coli, GI87081919, Length=562, Percent_Identity=39.5017793594306, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17537199, Length=556, Percent_Identity=36.6906474820144, Blast_Score=344, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6322823, Length=562, Percent_Identity=39.5017793594306, Blast_Score=419, Evalue=1e-118,
Organism=Drosophila melanogaster, GI21356279, Length=530, Percent_Identity=34.9056603773585, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI281362674, Length=530, Percent_Identity=34.9056603773585, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI281362672, Length=530, Percent_Identity=34.9056603773585, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24646388, Length=516, Percent_Identity=36.8217054263566, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24646386, Length=516, Percent_Identity=36.8217054263566, Blast_Score=336, Evalue=3e-92,
Organism=Drosophila melanogaster, GI281363505, Length=544, Percent_Identity=32.5367647058824, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI78707236, Length=544, Percent_Identity=32.5367647058824, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI281363503, Length=542, Percent_Identity=32.2878228782288, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI78707232, Length=520, Percent_Identity=32.8846153846154, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI78707242, Length=546, Percent_Identity=28.7545787545788, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI78707238, Length=546, Percent_Identity=28.7545787545788, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI78707240, Length=524, Percent_Identity=29.7709923664122, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI19922384, Length=556, Percent_Identity=27.3381294964029, Blast_Score=226, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62447; Mature: 62447

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSVIPIFVPVTKPRPLECRSYQTKCRGVAVLNSPMLNKGTAFTSKERKELGLTGLLPP
CCCCCEEEEEECCCCCCCCCCCHHHHHCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCC
EISTLGTQVKLAYIQYDRLPDTLAKNTYLTTLHAHNEVLFYRLFSEHLREMIPVLDDATL
CHHHCCCEEEEEEEEECCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHH
SLAAQRNHHECGQSRGVYLSIDHIDAMEEAFANLGADAGDIDLILTTDGEQVRGVGDAGM
HHHHHCCHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHCCCCCCCH
SGIERSLGKLAVYTAAGGINPNRAISVVLDVGTDRQDLLDDPTYIGNRHPRIRGKRYDAF
HHHHHHHHHEEEEEECCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHH
LESYVTTTTRLFPHAMLHWENFAPGNGRRLLEKYGGQVCTFNDDMQGTGAITLAAAISAV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHH
RICGTPLRNQRVVILGAGTAGVGIADQICDAMAREGLSRQEAVRQFWFVDRQGLLTSNMT
HHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCC
GQLRDHQVTFARPDVESRGWKQLHGGGIGLAEVVRQVKPTMLIGASSSSGSFTEPIIRQM
CCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHH
AAHTARPIIFVLSTPPVRAEANPADLIAWTAGRALIATGSLFAPVTYRGLTYVVAQLNNA
HHHCCCCEEEEEECCCCCCCCCCHHEEEEECCCEEEECCCEECCHHHHHHHHHHHHHCCE
MVYPGLSLGAVVARARRISEGMFEAAAGAVSSLVTVRHPGASLLPHIDDLSSVSMTVAAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHH
VAEAAVSEGLSRAPIDDIVQQVRDAMWQPEYHEIQAS
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHCCCC
>Mature Secondary Structure
MRQSVIPIFVPVTKPRPLECRSYQTKCRGVAVLNSPMLNKGTAFTSKERKELGLTGLLPP
CCCCCEEEEEECCCCCCCCCCCHHHHHCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCC
EISTLGTQVKLAYIQYDRLPDTLAKNTYLTTLHAHNEVLFYRLFSEHLREMIPVLDDATL
CHHHCCCEEEEEEEEECCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHH
SLAAQRNHHECGQSRGVYLSIDHIDAMEEAFANLGADAGDIDLILTTDGEQVRGVGDAGM
HHHHHCCHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHCCCCCCCH
SGIERSLGKLAVYTAAGGINPNRAISVVLDVGTDRQDLLDDPTYIGNRHPRIRGKRYDAF
HHHHHHHHHEEEEEECCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHH
LESYVTTTTRLFPHAMLHWENFAPGNGRRLLEKYGGQVCTFNDDMQGTGAITLAAAISAV
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHH
RICGTPLRNQRVVILGAGTAGVGIADQICDAMAREGLSRQEAVRQFWFVDRQGLLTSNMT
HHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCC
GQLRDHQVTFARPDVESRGWKQLHGGGIGLAEVVRQVKPTMLIGASSSSGSFTEPIIRQM
CCCCCCEEEEECCCCCCCCHHHHCCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHH
AAHTARPIIFVLSTPPVRAEANPADLIAWTAGRALIATGSLFAPVTYRGLTYVVAQLNNA
HHHCCCCEEEEEECCCCCCCCCCHHEEEEECCCEEEECCCEECCHHHHHHHHHHHHHCCE
MVYPGLSLGAVVARARRISEGMFEAAAGAVSSLVTVRHPGASLLPHIDDLSSVSMTVAAA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHH
VAEAAVSEGLSRAPIDDIVQQVRDAMWQPEYHEIQAS
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]