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The map label for this gene is virA [H]

Identifier: 116622005

GI number: 116622005

Start: 3663126

End: 3664361

Strand: Direct

Name: virA [H]

Synonym: Acid_2890

Alternate gene names: 116622005

Gene position: 3663126-3664361 (Clockwise)

Preceding gene: 116622004

Following gene: 116622009

Centisome position: 36.76

GC content: 62.3

Gene sequence:

>1236_bases
ATGCTGAGTACGGCGACGCAGCGGTTCGCGGGTCCGGACTACGCAGGGCATATCGGGACGATGGTGGATATCACGCAGCA
CAGGCGGGATCGGGAGCAGGGGCTGGCAGCGCAAAAGCTGGAGAGCCTTGGGGTGCTGGCGGGCGGAGTCGCGCACGATT
TCAACAACCTTTTGGGCAGCATTCTGGCGAATTCGGAATTGCTGCTGGCTGACCTTCCGGCTGACGCGCCTGCGCGGGAA
GGAATCGACAGGATCAACGCGGTGGCGGTGCGGGCGGCGGAGATTGTTCGCGAACTGATGACGTTTGCGGGGCATGAGAA
TCCGATTTTCGAGCCGGTGAGCATCAGCAGCCTGGTGCGCGAGATGCTCGAGTTGTTGAAGGTATCGATCTCGAAACTGG
CGGTGATACGGGTTGACCTGGCGGATGGCCTTCCCGCGGTTATGGCGAACGCGTCGCAGATCCGGCAGGTGGTGATGAAC
CTGATCACCAACGCATCGGAGGCGCTGGGCAAGGCGCATGGTGTGATTTCGGTGAGCAGTGACATGCGGCGGGTCCTGCG
CGACGATGCGGACACCGGCGAACTGGCGGAAGGCGAATACGTCCGGTTGAGAGTAAGCGACACGGGATGCGGAATGACCA
AAGAGATCCAGGACCGGATCTTCGATCCTTTCTTCAGTACCAAGTTCAGCGGGCGCGGGCTGGGTTTGGCGGCGGTGCAG
GGAATTGTGCGCAGTCACCGGGGAGCGATTCAACTGACGAGCGCGCCGGGGGAGGGTACGTGCTTCGAGGTCCTGCTGCC
GTGCGCGCCGCCAAATGCCAGGCCGCCGGACGAGGCGCGGGTTCCGGAGCCAGCGCCGGCGACCGCGAGTGCCGCGACGA
CGGTACTGGTGGTGGAGGACGAGGAGGTGCTGCGGGCCGCCGTTTGCAAGATGCTTCGCAAGAAGGATTTCATCGTGATC
GAAGCGGCGGATGGTAATGCTGCGCTGGAAGCGTTGCGCGGGCGGGCGGCGGAAATCGGCGTCATTTTATTGGATATGAC
GCTGCCGGGGATCTCGGGGAAGCAGTTGTTCGAAGAATTGCGGGCGATCCGTCCGGAGGCGCGAGTAATTCTGACCACGG
CTTATAGCAAAGAGATGGCAGCGAATGCACTCGGCAGCTTGGAGGCGTGGGGGTTCATTCGGAAGCCATATCATATTTCG
GATCTGGTGGCGATGCTGAGAAGCGCGGGGGAGTAG

Upstream 100 bases:

>100_bases
CCGGGAACGGGTGGAAGGGATCGTAATGGAAGCGGTGGCATCGTAGTGCGATTACCAGATGGAGTTTCGCCAATTGCGGT
CCGATGGGGAGTACCGCTGG

Downstream 100 bases:

>100_bases
GAGAAGGGTGCGTGGTGTATCGGGAAAGCCGCCTAAAAGGCGGCTGCGCAAGAGTGGCTGCCCCACAAGAATCTTCGCGG
CCCGCGGAGACAGGCCAGGA

Product: histidine kinase

Products: NA

Alternate protein names: WHR virA [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLSTATQRFAGPDYAGHIGTMVDITQHRRDREQGLAAQKLESLGVLAGGVAHDFNNLLGSILANSELLLADLPADAPARE
GIDRINAVAVRAAEIVRELMTFAGHENPIFEPVSISSLVREMLELLKVSISKLAVIRVDLADGLPAVMANASQIRQVVMN
LITNASEALGKAHGVISVSSDMRRVLRDDADTGELAEGEYVRLRVSDTGCGMTKEIQDRIFDPFFSTKFSGRGLGLAAVQ
GIVRSHRGAIQLTSAPGEGTCFEVLLPCAPPNARPPDEARVPEPAPATASAATTVLVVEDEEVLRAAVCKMLRKKDFIVI
EAADGNAALEALRGRAAEIGVILLDMTLPGISGKQLFEELRAIRPEARVILTTAYSKEMAANALGSLEAWGFIRKPYHIS
DLVAMLRSAGE

Sequences:

>Translated_411_residues
MLSTATQRFAGPDYAGHIGTMVDITQHRRDREQGLAAQKLESLGVLAGGVAHDFNNLLGSILANSELLLADLPADAPARE
GIDRINAVAVRAAEIVRELMTFAGHENPIFEPVSISSLVREMLELLKVSISKLAVIRVDLADGLPAVMANASQIRQVVMN
LITNASEALGKAHGVISVSSDMRRVLRDDADTGELAEGEYVRLRVSDTGCGMTKEIQDRIFDPFFSTKFSGRGLGLAAVQ
GIVRSHRGAIQLTSAPGEGTCFEVLLPCAPPNARPPDEARVPEPAPATASAATTVLVVEDEEVLRAAVCKMLRKKDFIVI
EAADGNAALEALRGRAAEIGVILLDMTLPGISGKQLFEELRAIRPEARVILTTAYSKEMAANALGSLEAWGFIRKPYHIS
DLVAMLRSAGE
>Mature_411_residues
MLSTATQRFAGPDYAGHIGTMVDITQHRRDREQGLAAQKLESLGVLAGGVAHDFNNLLGSILANSELLLADLPADAPARE
GIDRINAVAVRAAEIVRELMTFAGHENPIFEPVSISSLVREMLELLKVSISKLAVIRVDLADGLPAVMANASQIRQVVMN
LITNASEALGKAHGVISVSSDMRRVLRDDADTGELAEGEYVRLRVSDTGCGMTKEIQDRIFDPFFSTKFSGRGLGLAAVQ
GIVRSHRGAIQLTSAPGEGTCFEVLLPCAPPNARPPDEARVPEPAPATASAATTVLVVEDEEVLRAAVCKMLRKKDFIVI
EAADGNAALEALRGRAAEIGVILLDMTLPGISGKQLFEELRAIRPEARVILTTAYSKEMAANALGSLEAWGFIRKPYHIS
DLVAMLRSAGE

Specific function: Activates virG, by phosphorylating it, in the presence of acetosyringone or hydroxysyringone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=33.6206896551724, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788549, Length=273, Percent_Identity=29.3040293040293, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI48994928, Length=413, Percent_Identity=25.4237288135593, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081816, Length=367, Percent_Identity=25.0681198910082, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790300, Length=244, Percent_Identity=29.9180327868852, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693157, Length=276, Percent_Identity=27.1739130434783, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788713, Length=212, Percent_Identity=23.5849056603774, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=25.6198347107438, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43947; Mature: 43947

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSTATQRFAGPDYAGHIGTMVDITQHRRDREQGLAAQKLESLGVLAGGVAHDFNNLLGS
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILANSELLLADLPADAPAREGIDRINAVAVRAAEIVRELMTFAGHENPIFEPVSISSLVR
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
EMLELLKVSISKLAVIRVDLADGLPAVMANASQIRQVVMNLITNASEALGKAHGVISVSS
HHHHHHHHHHHHEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHCHHHHHHHHCCEEEEHH
DMRRVLRDDADTGELAEGEYVRLRVSDTGCGMTKEIQDRIFDPFFSTKFSGRGLGLAAVQ
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCHHHHCCCCCCCCHHHHHH
GIVRSHRGAIQLTSAPGEGTCFEVLLPCAPPNARPPDEARVPEPAPATASAATTVLVVED
HHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
EEVLRAAVCKMLRKKDFIVIEAADGNAALEALRGRAAEIGVILLDMTLPGISGKQLFEEL
HHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHHEEEEEEEEECCCCCHHHHHHHH
RAIRPEARVILTTAYSKEMAANALGSLEAWGFIRKPYHISDLVAMLRSAGE
HHCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLSTATQRFAGPDYAGHIGTMVDITQHRRDREQGLAAQKLESLGVLAGGVAHDFNNLLGS
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILANSELLLADLPADAPAREGIDRINAVAVRAAEIVRELMTFAGHENPIFEPVSISSLVR
HHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
EMLELLKVSISKLAVIRVDLADGLPAVMANASQIRQVVMNLITNASEALGKAHGVISVSS
HHHHHHHHHHHHEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHCHHHHHHHHCCEEEEHH
DMRRVLRDDADTGELAEGEYVRLRVSDTGCGMTKEIQDRIFDPFFSTKFSGRGLGLAAVQ
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCHHHHCCCCCCCCHHHHHH
GIVRSHRGAIQLTSAPGEGTCFEVLLPCAPPNARPPDEARVPEPAPATASAATTVLVVED
HHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
EEVLRAAVCKMLRKKDFIVIEAADGNAALEALRGRAAEIGVILLDMTLPGISGKQLFEEL
HHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCHHEEEEEEEEECCCCCHHHHHHHH
RAIRPEARVILTTAYSKEMAANALGSLEAWGFIRKPYHISDLVAMLRSAGE
HHCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2796735; 2194232; 11743193; 11743194 [H]