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The map label for this gene is yphC [H]

Identifier: 116621974

GI number: 116621974

Start: 3619884

End: 3620933

Strand: Reverse

Name: yphC [H]

Synonym: Acid_2859

Alternate gene names: 116621974

Gene position: 3620933-3619884 (Counterclockwise)

Preceding gene: 116621975

Following gene: 116621973

Centisome position: 36.33

GC content: 64.29

Gene sequence:

>1050_bases
ATGATTGGGGCCTATCTGCCGGGGAATAGCACGGTCGAGATGAAGGAAGTGCCGGTGCCGGTTCCGGCACACGGCGAGGT
TCTGCTGCGCATGAAGGCGTCAACCATCTGCGGCTCGGACATACGCTGCATTTATCACGAGCACCTGGGGAAGGGGCCGG
AAGGGTATCAGGGGGTCGTGGCCGGGCACGAGCCGTGCGGGCAGATCGTGAAGACGGGTCCGGGCTGCCGCCGTTTCGGG
GTTGGCGACCGGGTGATTGTCTATCATATCTCGGGCTGCGGAGTGTGCAACGACTGCCGGCGCGGGTACATGATTTCGTG
TACGAGCGAGCGCTACCGTCGCGCATACGGCTGGCAGCGCGACGGCGGCATGGCGGAGTTCCTGCTGGCCGAGGAGAAGG
ATCTGATTCCCCTCCCGGGGAAATTGAGTTACGCCGATGGGGCGCAGGTGGCATGCGGGTTCGGCACGGTGTACGAGGGG
CTGGAGAAGATCGGGATCAGCGGCAATGATGCCGTGCTGATCACGGGATTGGGGCCAGTGGGGCTGGCGACCGGTGCGCT
GTGCCGGAAGCTCGGCGCGGAGAAAATTATCGGTATCGATGTGGTTCCCGAGCGGATGAAGCTGGCGCTCGATCTCAAGC
TGTGTGATGAGGTGCTGGCCAGCGGGCCGGAGAATGTCGCGGAGGTAAGGCGGCTGACCGGCGGGCAAGGGGTGGAGCGC
GCGGTGGATTGCTCGGCGAACGAGCAGGCGAGGGCGACCGCGATCCGGGCGACGCGGAAGTGGGGGCGGATCGTGTTTCT
CGGGGAGGGTGGACGGGTGGAGTTCAACCCTTCGCCGGACATTATCCACGATCAAAAGACGATTTACGGATCGTGGGTGA
CCTCGACGTGGCTGATGGAGGAGCTGGTGGAGCGGCTGGTGAGGTGGAATCTGCATCCGGCGGACCTCGTGACGCACCGG
TTCCCGCTCGAGAGTGTGGACCAGGCGTACACGCTGATGGCGTCGGGGAAATGCGGGAAGGTCGCGGTCTGCTTCGACGA
AGAACTGTGA

Upstream 100 bases:

>100_bases
GAATCGATCGCAACTGCCGGCTGATTAAAGGGCAGGTATTTTTGTGGAAACAGGACCAGACGTGGGAAGATCTCTGGGAC
CTGAAGGGAGTGATCGCACA

Downstream 100 bases:

>100_bases
CGTGCCGGAAGTGTAAGGTCGCGATGAAAGAAGTAAAGGGCCACATTTTCCATAAGCAAAGGAAATGGCGATGCCCGAAG
TGTGCCAAGATTCGGATGCA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MIGAYLPGNSTVEMKEVPVPVPAHGEVLLRMKASTICGSDIRCIYHEHLGKGPEGYQGVVAGHEPCGQIVKTGPGCRRFG
VGDRVIVYHISGCGVCNDCRRGYMISCTSERYRRAYGWQRDGGMAEFLLAEEKDLIPLPGKLSYADGAQVACGFGTVYEG
LEKIGISGNDAVLITGLGPVGLATGALCRKLGAEKIIGIDVVPERMKLALDLKLCDEVLASGPENVAEVRRLTGGQGVER
AVDCSANEQARATAIRATRKWGRIVFLGEGGRVEFNPSPDIIHDQKTIYGSWVTSTWLMEELVERLVRWNLHPADLVTHR
FPLESVDQAYTLMASGKCGKVAVCFDEEL

Sequences:

>Translated_349_residues
MIGAYLPGNSTVEMKEVPVPVPAHGEVLLRMKASTICGSDIRCIYHEHLGKGPEGYQGVVAGHEPCGQIVKTGPGCRRFG
VGDRVIVYHISGCGVCNDCRRGYMISCTSERYRRAYGWQRDGGMAEFLLAEEKDLIPLPGKLSYADGAQVACGFGTVYEG
LEKIGISGNDAVLITGLGPVGLATGALCRKLGAEKIIGIDVVPERMKLALDLKLCDEVLASGPENVAEVRRLTGGQGVER
AVDCSANEQARATAIRATRKWGRIVFLGEGGRVEFNPSPDIIHDQKTIYGSWVTSTWLMEELVERLVRWNLHPADLVTHR
FPLESVDQAYTLMASGKCGKVAVCFDEEL
>Mature_349_residues
MIGAYLPGNSTVEMKEVPVPVPAHGEVLLRMKASTICGSDIRCIYHEHLGKGPEGYQGVVAGHEPCGQIVKTGPGCRRFG
VGDRVIVYHISGCGVCNDCRRGYMISCTSERYRRAYGWQRDGGMAEFLLAEEKDLIPLPGKLSYADGAQVACGFGTVYEG
LEKIGISGNDAVLITGLGPVGLATGALCRKLGAEKIIGIDVVPERMKLALDLKLCDEVLASGPENVAEVRRLTGGQGVER
AVDCSANEQARATAIRATRKWGRIVFLGEGGRVEFNPSPDIIHDQKTIYGSWVTSTWLMEELVERLVRWNLHPADLVTHR
FPLESVDQAYTLMASGKCGKVAVCFDEEL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=342, Percent_Identity=27.1929824561404, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=23.314606741573, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565152, Length=368, Percent_Identity=24.1847826086957, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4501939, Length=355, Percent_Identity=23.0985915492958, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565154, Length=364, Percent_Identity=24.1758241758242, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501929, Length=363, Percent_Identity=21.763085399449, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4501933, Length=364, Percent_Identity=21.7032967032967, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082125, Length=352, Percent_Identity=53.125, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=27.8409090909091, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI226510992, Length=320, Percent_Identity=26.25, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786825, Length=375, Percent_Identity=26.1333333333333, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788075, Length=349, Percent_Identity=25.7879656160458, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=337, Percent_Identity=25.8160237388724, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87081918, Length=325, Percent_Identity=28.3076923076923, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786552, Length=359, Percent_Identity=25.9052924791086, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787863, Length=333, Percent_Identity=25.8258258258258, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788073, Length=336, Percent_Identity=22.6190476190476, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=336, Percent_Identity=23.5119047619048, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=27.6967930029155, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=27.4853801169591, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=360, Percent_Identity=26.3888888888889, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=287, Percent_Identity=27.5261324041812, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=273, Percent_Identity=26.7399267399267, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=22.3719676549865, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=372, Percent_Identity=22.3118279569892, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=23.0088495575221, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=330, Percent_Identity=27.5757575757576, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=330, Percent_Identity=27.5757575757576, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=24.5231607629428, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=26.2686567164179, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=336, Percent_Identity=25.297619047619, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=270, Percent_Identity=27.4074074074074, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=270, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=329, Percent_Identity=24.3161094224924, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=270, Percent_Identity=25.1851851851852, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=356, Percent_Identity=27.5280898876405, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17137530, Length=268, Percent_Identity=27.2388059701493, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17737897, Length=267, Percent_Identity=27.3408239700375, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 37824; Mature: 37824

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGAYLPGNSTVEMKEVPVPVPAHGEVLLRMKASTICGSDIRCIYHEHLGKGPEGYQGVV
CCCEECCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEE
AGHEPCGQIVKTGPGCRRFGVGDRVIVYHISGCGVCNDCRRGYMISCTSERYRRAYGWQR
CCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHCCCEEEEECHHHHHHHCCCCC
DGGMAEFLLAEEKDLIPLPGKLSYADGAQVACGFGTVYEGLEKIGISGNDAVLITGLGPV
CCCCEEEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCEEEEEECCHH
GLATGALCRKLGAEKIIGIDVVPERMKLALDLKLCDEVLASGPENVAEVRRLTGGQGVER
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHH
AVDCSANEQARATAIRATRKWGRIVFLGEGGRVEFNPSPDIIHDQKTIYGSWVTSTWLME
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCEECCCEEEEHHHHHHHHHH
ELVERLVRWNLHPADLVTHRFPLESVDQAYTLMASGKCGKVAVCFDEEL
HHHHHHHHCCCCHHHHHHHCCCHHHHHHHEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure
MIGAYLPGNSTVEMKEVPVPVPAHGEVLLRMKASTICGSDIRCIYHEHLGKGPEGYQGVV
CCCEECCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEE
AGHEPCGQIVKTGPGCRRFGVGDRVIVYHISGCGVCNDCRRGYMISCTSERYRRAYGWQR
CCCCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCCHHHHCCCEEEEECHHHHHHHCCCCC
DGGMAEFLLAEEKDLIPLPGKLSYADGAQVACGFGTVYEGLEKIGISGNDAVLITGLGPV
CCCCEEEEEECCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCCEEEEEECCHH
GLATGALCRKLGAEKIIGIDVVPERMKLALDLKLCDEVLASGPENVAEVRRLTGGQGVER
HHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHH
AVDCSANEQARATAIRATRKWGRIVFLGEGGRVEFNPSPDIIHDQKTIYGSWVTSTWLME
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCEECCCEEEEHHHHHHHHHH
ELVERLVRWNLHPADLVTHRFPLESVDQAYTLMASGKCGKVAVCFDEEL
HHHHHHHHCCCCHHHHHHHCCCHHHHHHHEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]