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The map label for this gene is algD [H]

Identifier: 116619688

GI number: 116619688

Start: 666308

End: 667645

Strand: Direct

Name: algD [H]

Synonym: Acid_0553

Alternate gene names: 116619688

Gene position: 666308-667645 (Clockwise)

Preceding gene: 116619684

Following gene: 116619689

Centisome position: 6.69

GC content: 63.68

Gene sequence:

>1338_bases
GTGTCGCATGGCATACTAAAGGTCGTGGATCCCGTTTCCCTAGCAGTAAACCCCCAGAAAATTGCCGTGCTTGGACTTGG
TTACGTTGGCTGCGTAACCGCCGCCTGCCTGGCGCGGATCGGCCACCGTGTCACCGGCGTGGACCGGGATCAGTTCAAAG
TGGACAGCGTGCTTGGCGGCCGGGCGCCTTTCTTCGAGCCTGGATTGGAGGAACTGGTTGGAGACGGCGTGGCCACGGGT
CGCCTCTCCGCGACGGTCTCGCTGGCGGATGCGGTAGCCGATGCCGACGTGGCCCTGATTTGCGTGGGCACGCCATCGGA
AAAGAACGGGAACCTGGGGCTGGACCAATTGCGCCGCGTGTCCCAGGAGCTTGCGGAACTGCTGCCGGGACGGACGAAGC
GCCTGATCGTGGCAGTGCGCAGCACGGTCTATCCCGGAACCTGCGAAGAGATCGTTCTGCCGGCGTTTGGTGGTTCGCCC
CTGGTCGCCGTGGTCTCGAACCCGGAGTTTCTGCGCGAGGGCGCGGCGGTTCGCGACTTCATGGAGCCTTCGCTGCTCGT
GGTGGGCGGATCCTCGCCCGAGGCTGTCCGGCAGGTGGCAGGCATTTATTCGGGGCTGGCGGTGGAACCCTCGATTGTGG
CGCTGCGTACGGCGGAGATGATCAAGTACGCTTGCAACGCCTTCCATGCGGTGAAGATCTCCTTCGCCAATGAGATTGGG
GCGCTGGCGGGCGAACTGGGGATCGATGGCGCGGAGGTCATGGAGACGCTCTGCCGCGATCATTCGCTGAATATCTCGCC
CGCCTACCTGAAGCCGGGATTTGCGTTCGGCGGCTCCTGCCTGCCCAAGGATTTGCGTGCGCTGGTTTATCGCGCTTCGC
GGCTGGACCTGAAACTGCCGATGCTGGAATCCGTACTGCCCTCCAATAATGCACAGTTGGACCGGGCGATTGCGGTGGCG
CTGGATCTTCCGGGCGAGCGCATCGGCGTCTTCGGCCTGGCATTCAAGGAAAACACCGACGACCTGCGCGAGAGTCCGGT
GGTGCTGCTGCTGGAGACCCTGATCGGCAAGGGGCGCAAGGTCCGGGTGCACGACCCGCACATCCAGCTCGGCGAGATTT
ACGGTAGCAATCAGCGTTACATCATGAACGCCATCCCTCATATCGGCAATCTGCTGGACGACCGGTTGGATGGCATGCTG
GAGTGGGCCGACCACATTCTGGTGGCGCAGAAGCCCTCCCCCGCCGTGCAGGCGCGACTTATCGCAAGCGGCAAGCCGCT
GATCGACCTGGTGGGTGCGCTGCGGCGCGATTTGGGCCGGGCCACGGTATCCGTTTAG

Upstream 100 bases:

>100_bases
CCAGCCCCAGCAGGACCAGCCGTTTAATGGTTCGCATGAAGTTGGCGCTAAGCCCCATTATGCCGTAAGTCACCGCACCG
GGGCCACGGATGAACCCGGC

Downstream 100 bases:

>100_bases
CTCTCCCCTAAAGTCCGGCGTCACTTCTGCCGAATTAGAAGGTGACGCTTATGATCCGGACGTGTTTGACCTCCATCCTG
TTCTTGGCGGGTTTCGCCGC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: NA

Alternate protein names: GMD [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MSHGILKVVDPVSLAVNPQKIAVLGLGYVGCVTAACLARIGHRVTGVDRDQFKVDSVLGGRAPFFEPGLEELVGDGVATG
RLSATVSLADAVADADVALICVGTPSEKNGNLGLDQLRRVSQELAELLPGRTKRLIVAVRSTVYPGTCEEIVLPAFGGSP
LVAVVSNPEFLREGAAVRDFMEPSLLVVGGSSPEAVRQVAGIYSGLAVEPSIVALRTAEMIKYACNAFHAVKISFANEIG
ALAGELGIDGAEVMETLCRDHSLNISPAYLKPGFAFGGSCLPKDLRALVYRASRLDLKLPMLESVLPSNNAQLDRAIAVA
LDLPGERIGVFGLAFKENTDDLRESPVVLLLETLIGKGRKVRVHDPHIQLGEIYGSNQRYIMNAIPHIGNLLDDRLDGML
EWADHILVAQKPSPAVQARLIASGKPLIDLVGALRRDLGRATVSV

Sequences:

>Translated_445_residues
MSHGILKVVDPVSLAVNPQKIAVLGLGYVGCVTAACLARIGHRVTGVDRDQFKVDSVLGGRAPFFEPGLEELVGDGVATG
RLSATVSLADAVADADVALICVGTPSEKNGNLGLDQLRRVSQELAELLPGRTKRLIVAVRSTVYPGTCEEIVLPAFGGSP
LVAVVSNPEFLREGAAVRDFMEPSLLVVGGSSPEAVRQVAGIYSGLAVEPSIVALRTAEMIKYACNAFHAVKISFANEIG
ALAGELGIDGAEVMETLCRDHSLNISPAYLKPGFAFGGSCLPKDLRALVYRASRLDLKLPMLESVLPSNNAQLDRAIAVA
LDLPGERIGVFGLAFKENTDDLRESPVVLLLETLIGKGRKVRVHDPHIQLGEIYGSNQRYIMNAIPHIGNLLDDRLDGML
EWADHILVAQKPSPAVQARLIASGKPLIDLVGALRRDLGRATVSV
>Mature_444_residues
SHGILKVVDPVSLAVNPQKIAVLGLGYVGCVTAACLARIGHRVTGVDRDQFKVDSVLGGRAPFFEPGLEELVGDGVATGR
LSATVSLADAVADADVALICVGTPSEKNGNLGLDQLRRVSQELAELLPGRTKRLIVAVRSTVYPGTCEEIVLPAFGGSPL
VAVVSNPEFLREGAAVRDFMEPSLLVVGGSSPEAVRQVAGIYSGLAVEPSIVALRTAEMIKYACNAFHAVKISFANEIGA
LAGELGIDGAEVMETLCRDHSLNISPAYLKPGFAFGGSCLPKDLRALVYRASRLDLKLPMLESVLPSNNAQLDRAIAVAL
DLPGERIGVFGLAFKENTDDLRESPVVLLLETLIGKGRKVRVHDPHIQLGEIYGSNQRYIMNAIPHIGNLLDDRLDGMLE
WADHILVAQKPSPAVQARLIASGKPLIDLVGALRRDLGRATVSV

Specific function: Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and ant

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=377, Percent_Identity=30.5039787798408, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI296040443, Length=226, Percent_Identity=32.7433628318584, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI296040438, Length=225, Percent_Identity=32.8888888888889, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1788340, Length=364, Percent_Identity=26.3736263736264, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI48994968, Length=359, Percent_Identity=29.5264623955432, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17560350, Length=380, Percent_Identity=32.8947368421053, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17136908, Length=378, Percent_Identity=29.6296296296296, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.132 [H]

Molecular weight: Translated: 47232; Mature: 47101

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHGILKVVDPVSLAVNPQKIAVLGLGYVGCVTAACLARIGHRVTGVDRDQFKVDSVLGG
CCCCCEEEECCCEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
RAPFFEPGLEELVGDGVATGRLSATVSLADAVADADVALICVGTPSEKNGNLGLDQLRRV
CCCCCCCCHHHHHCCCCCCCCHHEEEHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHH
SQELAELLPGRTKRLIVAVRSTVYPGTCEEIVLPAFGGSPLVAVVSNPEFLREGAAVRDF
HHHHHHHCCCCCCEEEEEEHHHCCCCCHHHEEEECCCCCCEEEEECCHHHHHCCHHHHHH
MEPSLLVVGGSSPEAVRQVAGIYSGLAVEPSIVALRTAEMIKYACNAFHAVKISFANEIG
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHH
ALAGELGIDGAEVMETLCRDHSLNISPAYLKPGFAFGGSCLPKDLRALVYRASRLDLKLP
HHHHHCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEECC
MLESVLPSNNAQLDRAIAVALDLPGERIGVFGLAFKENTDDLRESPVVLLLETLIGKGRK
HHHHHCCCCCCCHHEEEEEEEECCCCCEEEEEEEECCCCHHHHHCCHHHHHHHHHCCCCE
VRVHDPHIQLGEIYGSNQRYIMNAIPHIGNLLDDRLDGMLEWADHILVAQKPSPAVQARL
EEEECCCEEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHEEE
IASGKPLIDLVGALRRDLGRATVSV
ECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHGILKVVDPVSLAVNPQKIAVLGLGYVGCVTAACLARIGHRVTGVDRDQFKVDSVLGG
CCCCEEEECCCEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
RAPFFEPGLEELVGDGVATGRLSATVSLADAVADADVALICVGTPSEKNGNLGLDQLRRV
CCCCCCCCHHHHHCCCCCCCCHHEEEHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHH
SQELAELLPGRTKRLIVAVRSTVYPGTCEEIVLPAFGGSPLVAVVSNPEFLREGAAVRDF
HHHHHHHCCCCCCEEEEEEHHHCCCCCHHHEEEECCCCCCEEEEECCHHHHHCCHHHHHH
MEPSLLVVGGSSPEAVRQVAGIYSGLAVEPSIVALRTAEMIKYACNAFHAVKISFANEIG
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHH
ALAGELGIDGAEVMETLCRDHSLNISPAYLKPGFAFGGSCLPKDLRALVYRASRLDLKLP
HHHHHCCCCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEECC
MLESVLPSNNAQLDRAIAVALDLPGERIGVFGLAFKENTDDLRESPVVLLLETLIGKGRK
HHHHHCCCCCCCHHEEEEEEEECCCCCEEEEEEEECCCCHHHHHCCHHHHHHHHHCCCCE
VRVHDPHIQLGEIYGSNQRYIMNAIPHIGNLLDDRLDGMLEWADHILVAQKPSPAVQARL
EEEECCCEEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHEEE
IASGKPLIDLVGALRRDLGRATVSV
ECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]