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The map label for this gene is lctO [C]

Identifier: 116517149

GI number: 116517149

Start: 642496

End: 643632

Strand: Direct

Name: lctO [C]

Synonym: SPD_0621

Alternate gene names: 116517149

Gene position: 642496-643632 (Clockwise)

Preceding gene: 116517090

Following gene: 116516305

Centisome position: 31.4

GC content: 45.73

Gene sequence:

>1137_bases
ATGTCATACAAAACAAGCAATGCAGAAGGCCATGTAGATTTCATCAATACCTATGATTTGGAGCCAATGGCGCAACAAGT
TATTCCTAAAGCAGCATTTGGCTATATCGCTAGTGGGGCGGAAGATACTTTCACTTTAAGAGAGAATATCCGCGCCTTTA
ACCACAAACTCATCGTTCCTCATACACTTTGCGATGTTGAAAATCCAAGTACAGAGATTGAATTTGCAGGTGAAAAACTA
TCTTCACCAATCATTATGGCGCCTGTTGCGGCCCATAAATTAGCGAATGAACAGGGGGAAGTGGCGACTGCGCGTGGTGT
GCATGAGTTTGGTTCTCTTTATACAACCAGTTCTTACTCTACTGTTGACCTTCCAGAGATTTCTGAAGCCCTTCAAGGGA
CACCTCATTGGTTTCAATTTTACTTTAGTAAGGATGACGGTATCAACCGCCACATCATGGACCGTGTGAAGGCTGAAGGT
TATAAAGCGATTGTCTTGACGGCAGATGCTACTGTAGGGGGGAATCGTGAAGTGGATAAGCGTAATGGTTTTGTCTTCCC
AGTTGGCATGCCGATTGTTGAAGAATACCTGCCAGAAGGTGCTGGTAAATCAATGGACTTTGTTTATAAATCAGCTAAAC
AACGCTTGTCTCCACGCGATGTAGAATTTATCGCTGAATACTCTGGTCTTCCTGTGTATGTCAAGGGACCACAATGCCGT
GAGGACGTTGAACGTTCGCTTGCTGCAGGAGCTTCTGGTATCTGGGTAACCAACCACGGTGGTCGTCAAATCGACGGTGG
ACCAGCTGCCTTTGACTCGCTTCAAGAAGTGGCAGAAGCAGTTGATAGACGTGTGCCGATTGTCTTTGACTCTGGTGTTC
GTCGTGGTCAACACGTCTTTAAAGCCTTGGCTTCAGGAGCAGACTTGGTAGCTATTGGTCGCCCTGTTATCTATGGCTTG
GCTCTCGGTGGTAGTGTCGGTGTGCGTCAAGTCTTTGAACACTTGAATGCGGAATTGAAGACAGTTATGCAATTGTCTGG
AGCTCAGACCATTGAAGATGTCAAACACTTTAAGCTCCGTCACAATCCATACAACCCAACCTTCCCAGTTGACCCTCGTG
ACTTAAAATTGTATTGA

Upstream 100 bases:

>100_bases
AAGATGGTTTTTAAGCAAAACTCTTGAAAATGATTGAAAAAAGAGTTATTATAGTTGTATAGTAAAAAGCAAACGCTTAC
TTAATCAAGGAGGACAGTTT

Downstream 100 bases:

>100_bases
TAAAACAGATTGCCTCCACTGAATGTGGAGGTTTTTCTTCGTGTATTGGAAGAATAAATTGCTATCGAAAACTATAGTAA
AATGAAATAAGAATAGGACA

Product: lactate oxidase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTFTLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKL
SSPIIMAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEG
YKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCR
EDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGL
ALGGSVGVRQVFEHLNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY

Sequences:

>Translated_378_residues
MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTFTLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKL
SSPIIMAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEG
YKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCR
EDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGL
ALGGSVGVRQVFEHLNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY
>Mature_377_residues
SYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTFTLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKLS
SPIIMAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEGY
KAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCRE
DVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLA
LGGSVGVRQVFEHLNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=361, Percent_Identity=34.6260387811634, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI54234014, Length=345, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI7705393, Length=345, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI1790033, Length=369, Percent_Identity=30.6233062330623, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI193208036, Length=352, Percent_Identity=38.3522727272727, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=264, Percent_Identity=35.9848484848485, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323587, Length=358, Percent_Identity=31.8435754189944, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI78707188, Length=357, Percent_Identity=32.4929971988796, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI281363140, Length=357, Percent_Identity=32.4929971988796, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI78707190, Length=357, Percent_Identity=32.4929971988796, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 41489; Mature: 41358

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTFTLRENIRAFNHKLIVP
CCCCCCCCCCCEEEEECCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEECC
HTLCDVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYS
HHEECCCCCCCCEEECCHHHCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHHCEEECCCCC
TVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEGYKAIVLTADATVGGNREVDK
CCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
RNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCR
CCCEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCHH
EDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVF
HHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
KALASGADLVAIGRPVIYGLALGGSVGVRQVFEHLNAELKTVMQLSGAQTIEDVKHFKLR
HHHHCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
HNPYNPTFPVDPRDLKLY
CCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTFTLRENIRAFNHKLIVP
CCCCCCCCCCEEEEECCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEECC
HTLCDVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVATARGVHEFGSLYTTSSYS
HHEECCCCCCCCEEECCHHHCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHHCEEECCCCC
TVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEGYKAIVLTADATVGGNREVDK
CCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
RNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSPRDVEFIAEYSGLPVYVKGPQCR
CCCEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCHH
EDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQEVAEAVDRRVPIVFDSGVRRGQHVF
HHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
KALASGADLVAIGRPVIYGLALGGSVGVRQVFEHLNAELKTVMQLSGAQTIEDVKHFKLR
HHHHCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
HNPYNPTFPVDPRDLKLY
CCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]