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The map label for this gene is sulD [H]

Identifier: 116517074

GI number: 116517074

Start: 270918

End: 271730

Strand: Direct

Name: sulD [H]

Synonym: SPD_0272

Alternate gene names: 116517074

Gene position: 270918-271730 (Clockwise)

Preceding gene: 116515945

Following gene: 116516171

Centisome position: 13.24

GC content: 45.02

Gene sequence:

>813_bases
ATGGATCAACTGCAGATTAAGGATTTGGAAATGTTTGCCTATCATGGTCTTTTTCCTAGTGAGAAAGAATTGGGGCAGAA
ATTTATCGTTTCAGCCATCCTATCCTATGATATGACCAAGGCAGCTACAGACTTGGATTTAACAGCCTCTGTCCATTACG
GAGAATTGTGTCAGCAGTGGACGACTTGGTTTCAGGAAACGAGTGAAGATTTGATTGAAACGGTAGCCTATAAACTGGTG
GAACGTACCTTTGAGTCTTATCCTCTTGTCCAAGAAATGAAGTTGGAACTGAAAAAACCTTGGGCACCGGTGCATTTGTC
ACTAGATACTTGCTCGGTAACCATTCATCGCCGCAAGCAACGAGCCTTTATCGCCCTAGGAAGCAATATGGGAGATAAGC
AAGCAAACTTGAAGCAAGCCATTGACAAACTGCGAGCTCGTGGCATCCATATTCTCAAAGAGTCCAGTGTCTTAGCGACG
GAGCCTTGGGGTGGAGTGGAGCAGGATAGCTTTGCCAATCAAGTGGTTGAGGTGGAAACCTGGCTACCAGCACAAGACTT
GTTAGAAACCTTGTTAGCCATTGAGTCAGAGCTGGGACGGGTGAGAGAAGTGCATTGGGGACCTCGTTTGATTGATTTGG
ACTTGCTCTTTGTGGAGGACCAGATCCTTTATACAGACGACCTCATATTGCCTCATCCTTACATAGCGGAACGCCTTTTT
GTCCTTGAGTCCTTACAGGAAATTGCGCCTCATTTTATCCATCCGATATTAAAACAACCGATCCGCAACTTGTATGATGC
TTTGAAAAAATAG

Upstream 100 bases:

>100_bases
TCTATTTGAAACAGATAAGGACCTCCGCGACCAAGCTTATCGTTTAATGGGGCTATAAAAAGAATCCGTTTCAAGCGGAT
TTTTCTAGAAAGGAATCATT

Downstream 100 bases:

>100_bases
AAAAACTCTAGTTTTCAGTTACTTGCAACTGAAGGCTAGAGTTTTTAAAATAGGTCATTTTCTTCTGGGAGGAGGATAGT
TTCTCTACCGTCCATGTCTA

Product: bifunctional folate synthesis protein

Products: NA

Alternate protein names: Dihydroneopterin aldolase; DHNA; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MDQLQIKDLEMFAYHGLFPSEKELGQKFIVSAILSYDMTKAATDLDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLV
ERTFESYPLVQEMKLELKKPWAPVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLAT
EPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLF
VLESLQEIAPHFIHPILKQPIRNLYDALKK

Sequences:

>Translated_270_residues
MDQLQIKDLEMFAYHGLFPSEKELGQKFIVSAILSYDMTKAATDLDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLV
ERTFESYPLVQEMKLELKKPWAPVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLAT
EPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLF
VLESLQEIAPHFIHPILKQPIRNLYDALKK
>Mature_270_residues
MDQLQIKDLEMFAYHGLFPSEKELGQKFIVSAILSYDMTKAATDLDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLV
ERTFESYPLVQEMKLELKKPWAPVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLAT
EPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLF
VLESLQEIAPHFIHPILKQPIRNLYDALKK

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=38.1294964028777, Blast_Score=84, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324073, Length=159, Percent_Identity=40.8805031446541, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157
- InterPro:   IPR000550 [H]

Pfam domain/function: PF02152 FolB; PF01288 HPPK [H]

EC number: =4.1.2.25; =2.7.6.3 [H]

Molecular weight: Translated: 31097; Mature: 31097

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQLQIKDLEMFAYHGLFPSEKELGQKFIVSAILSYDMTKAATDLDLTASVHYGELCQQW
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
TTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWAPVHLSLDTCSVTIHRRKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECHHEEEEHHHHH
RAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLATEPWGGVEQDSFANQVVEVET
HEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHH
WLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEEECCCCCCCHHHHHHHH
VLESLQEIAPHFIHPILKQPIRNLYDALKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQLQIKDLEMFAYHGLFPSEKELGQKFIVSAILSYDMTKAATDLDLTASVHYGELCQQW
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHH
TTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWAPVHLSLDTCSVTIHRRKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECHHEEEEHHHHH
RAFIALGSNMGDKQANLKQAIDKLRARGIHILKESSVLATEPWGGVEQDSFANQVVEVET
HEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHH
WLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFVEDQILYTDDLILPHPYIAERLF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEEECCCCCCCHHHHHHHH
VLESLQEIAPHFIHPILKQPIRNLYDALKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2168367; 7798151; 11463916; 8385663 [H]