BacMap

Definition	Streptococcus pneumoniae D39, complete genome.
Accession	NC_008533
Length	2,046,115

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The map label for this gene is dnaJ [H]

Identifier: 116516829

GI number: 116516829

Start: 472171

End: 473289

Strand: Direct

Name: dnaJ [H]

Synonym: SPD_0461

Alternate gene names: 116516829

Gene position: 472171-473289 (Clockwise)

Preceding gene: 116516498

Following gene: 116515745

Centisome position: 23.08

GC content: 46.47

Gene sequence:

>1119_bases
ATGAACAATACTGAATTTTATGATCGTCTGGGGGTATCCAAAAACGCTTCGGCAGACGAAATCAAAAAGGCTTATCGTAA
GCTTTCCAAAAAATATCACCCAGATATCAACAAGGAGCCTGGTGCTGAGGACAAGTACAAGGAAGTTCAAGAAGCCTATG
AGACTTTGAGTGACGACCAAAAACGTGCTGCCTATGACCAGTATGGTGCTGCAGGCGCCAATGGTGGTTTCGGTGGTTTC
AATGGGGCAGGTGGCTTCGGTGGTTTTGAGGATATTTTCTCAAGTTTCTTCGGCGGAGGCGGTTCTTCGCGCAATCCAAA
CGCTCCTCGCCAAGGAGATGATCTCCAGTATCGTGTCAATTTGACCTTTGAAGAAGCTATCTTCGGAACTGAGAAGGAAG
TTAAGTATCATCGTGAAGCTGGCTGTCGTACATGTAATGGCTCTGGTGCTAAGCCAGGGACAAGTCCAGTCACTTGTGGA
CGCTGTCATGGCGCTGGTGTCATTAACGTCGATACGCAGACTCCTCTTGGTATGATGCGTCGCCAAGTAACCTGTGATGT
CTGTCACGGTCGAGGAAAAGAAATCAAATATCCATGTACAACCTGTCATGGAACAGGTCATGAGAAACAAGCTCATAGCG
TACATGTGAAAATCCCTGCTGGTGTGGAAACAGGTCAACAAATTCGCCTCGCTGGTCAAGGTGAAGCAGGCTTTAACGGT
GGACCTTATGGTGACTTGTATGTAGTAGTTTCTGTGGAAGCTAGCGACAAGTTTGAACGTGAAGGAACGACTATCTTCTA
CAATCTCAACCTCAACTTTGTCCAAGCGGCTCTTGGTGATACAGTAGATATTCCAACTGTTCACGGTGATGTTGAATTGG
TTATTCCAGAGGGAACTCAGACTGGTAAGAAATTCCGCCTACGTAGTAAGGGGGCACCGAGCCTTCGTGGCGGTGCAGTT
GGTGACCAATACGTTACTGTTAATGTCGTAACACCGACAGGCTTGAACGACCGCCAAAAAGTAGCCTTGAAAGAATTCGC
GGCTGCTGGTGACTTGAAAGTAAATCCAAAGAAAAAAGGCTTCTTTGACCATATTAAAGATGCCTTTGATGGAGAATAA

Upstream 100 bases:

>100_bases
ATGGACTGTGCCAAAAAGATAGTTTTTTCTAGGACGTAAGCGTCCGTCGTCAAAACTCCTAGATGGCTGTGTCCGTTTGA
CGCCCTTTGTATCTTGAATT

Downstream 100 bases:

>100_bases
TACTCTTCGAAAATCTCTTCAAACCACGTCAGCGTCGGCTTGCCATGGGTATGGTTACTGACTTCGTCAGTTCTATCCAC
AACCTTAAAACGGTGTTTTG

Product: chaperone protein DnaJ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGF
NGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCG
RCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQGEAGFNG
GPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAV
GDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE

Sequences:

>Translated_372_residues
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGF
NGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCG
RCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQGEAGFNG
GPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAV
GDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE
>Mature_372_residues
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGF
NGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCG
RCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQGEAGFNG
GPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAV
GDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon

COG id: COG0484

COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain [H]

Homologues:

Organism=Homo sapiens, GI205360838, Length=355, Percent_Identity=36.6197183098592, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI205360840, Length=355, Percent_Identity=36.6197183098592, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4504511, Length=318, Percent_Identity=32.3899371069182, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI194328760, Length=338, Percent_Identity=31.3609467455621, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI194328758, Length=337, Percent_Identity=30.8605341246291, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5031741, Length=343, Percent_Identity=32.6530612244898, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI201862587, Length=352, Percent_Identity=30.6818181818182, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI56549115, Length=352, Percent_Identity=30.6818181818182, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI201862518, Length=352, Percent_Identity=30.6818181818182, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7706495, Length=360, Percent_Identity=29.4444444444444, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI6631085, Length=368, Percent_Identity=27.445652173913, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI5453690, Length=360, Percent_Identity=25.5555555555556, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI194328762, Length=297, Percent_Identity=27.6094276094276, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI56687498, Length=68, Percent_Identity=58.8235294117647, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI47777312, Length=105, Percent_Identity=47.6190476190476, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI194306642, Length=108, Percent_Identity=44.4444444444444, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI194306640, Length=108, Percent_Identity=44.4444444444444, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI9558755, Length=112, Percent_Identity=43.75, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI27151736, Length=107, Percent_Identity=45.7943925233645, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI88501736, Length=107, Percent_Identity=45.7943925233645, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI21553335, Length=86, Percent_Identity=48.8372093023256, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI39204547, Length=171, Percent_Identity=30.9941520467836, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI23503241, Length=103, Percent_Identity=45.6310679611651, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI72534740, Length=101, Percent_Identity=43.5643564356436, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI17388799, Length=105, Percent_Identity=50.4761904761905, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4885495, Length=105, Percent_Identity=49.5238095238095, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI22749377, Length=100, Percent_Identity=41, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI45504382, Length=68, Percent_Identity=52.9411764705882, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI68077168, Length=75, Percent_Identity=50.6666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI68077166, Length=75, Percent_Identity=50.6666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI217035105, Length=76, Percent_Identity=44.7368421052632, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI29126218, Length=68, Percent_Identity=50, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI24308127, Length=76, Percent_Identity=44.7368421052632, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI21361912, Length=61, Percent_Identity=49.1803278688525, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786197, Length=378, Percent_Identity=49.2063492063492, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1787235, Length=367, Percent_Identity=30.2452316076294, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17553096, Length=376, Percent_Identity=34.0425531914894, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17553098, Length=376, Percent_Identity=34.0425531914894, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17507263, Length=343, Percent_Identity=31.7784256559767, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17563890, Length=304, Percent_Identity=33.2236842105263, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI212645553, Length=358, Percent_Identity=29.8882681564246, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17534355, Length=102, Percent_Identity=54.9019607843137, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538236, Length=112, Percent_Identity=42.8571428571429, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17554644, Length=102, Percent_Identity=42.156862745098, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=90, Percent_Identity=38.8888888888889, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115532476, Length=64, Percent_Identity=45.3125, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568643, Length=69, Percent_Identity=47.8260869565217, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324265, Length=338, Percent_Identity=35.207100591716, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321094, Length=390, Percent_Identity=37.1794871794872, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323870, Length=362, Percent_Identity=30.1104972375691, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323119, Length=373, Percent_Identity=27.8820375335121, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324252, Length=302, Percent_Identity=28.476821192053, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6322194, Length=102, Percent_Identity=48.0392156862745, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323813, Length=106, Percent_Identity=45.2830188679245, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320888, Length=102, Percent_Identity=40.1960784313725, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322388, Length=68, Percent_Identity=48.5294117647059, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45552811, Length=379, Percent_Identity=34.8284960422164, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45552813, Length=379, Percent_Identity=34.8284960422164, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI45549272, Length=379, Percent_Identity=35.0923482849604, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129487, Length=283, Percent_Identity=35.6890459363958, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24584014, Length=283, Percent_Identity=35.6890459363958, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28574949, Length=358, Percent_Identity=28.4916201117318, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI85726398, Length=375, Percent_Identity=30.1333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646562, Length=357, Percent_Identity=30.2521008403361, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646560, Length=357, Percent_Identity=30.2521008403361, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646558, Length=357, Percent_Identity=30.2521008403361, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646556, Length=357, Percent_Identity=30.2521008403361, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21357547, Length=357, Percent_Identity=30.2521008403361, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19920464, Length=348, Percent_Identity=28.1609195402299, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24658562, Length=68, Percent_Identity=60.2941176470588, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24658555, Length=68, Percent_Identity=60.2941176470588, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI18858081, Length=365, Percent_Identity=25.7534246575342, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24654066, Length=116, Percent_Identity=38.7931034482759, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24654070, Length=116, Percent_Identity=38.7931034482759, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24654068, Length=116, Percent_Identity=38.7931034482759, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24654072, Length=116, Percent_Identity=38.7931034482759, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24668492, Length=68, Percent_Identity=45.5882352941176, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737735, Length=68, Percent_Identity=52.9411764705882, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668523, Length=68, Percent_Identity=52.9411764705882, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574723, Length=68, Percent_Identity=52.9411764705882, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358273, Length=119, Percent_Identity=36.1344537815126, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012724
- InterPro:   IPR002939
- InterPro:   IPR001623
- InterPro:   IPR018253
- InterPro:   IPR008971
- InterPro:   IPR015609
- InterPro:   IPR003095
- InterPro:   IPR001305 [H]

Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG [H]

EC number: NA

Molecular weight: Translated: 40056; Mature: 40056

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00626 RCC1_2 ; PS00636 DNAJ_1 ; PS50076 DNAJ_2 ; PS00637 DNAJ_CXXCXGXG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQ
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHH
KRAAYDQYGAAGANGGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVN
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
LTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCGRCHGAGVINVDTQTPLGMMR
EEEHHHHCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
RQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQGEAGFNG
HHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCC
GPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQ
CCCCCEEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCEECCCEEEEECCCCC
TGKKFRLRSKGAPSLRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKG
CCCEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCC
FFDHIKDAFDGE
HHHHHHHHHCCC
>Mature Secondary Structure
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQ
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHH
KRAAYDQYGAAGANGGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVN
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEE
LTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCGRCHGAGVINVDTQTPLGMMR
EEEHHHHCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHH
RQVTCDVCHGRGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQGEAGFNG
HHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCC
GPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQ
CCCCCEEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCEECCCEEEEECCCCC
TGKKFRLRSKGAPSLRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKG
CCCEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCC
FFDHIKDAFDGE
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]