BacMap

Definition	Streptococcus pneumoniae D39, complete genome.
Accession	NC_008533
Length	2,046,115

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The map label for this gene is fhuC [C]

Identifier: 116516786

GI number: 116516786

Start: 647676

End: 649061

Strand: Direct

Name: fhuC [C]

Synonym: SPD_0626

Alternate gene names: 116516786

Gene position: 647676-649061 (Clockwise)

Preceding gene: 116516079

Following gene: 116516329

Centisome position: 31.65

GC content: 43.36

Gene sequence:

>1386_bases
ATGGGTCTGGAACTACGAGCGATTCAGTCCCCAATCTTCTCTGAGCCGTTTGATTTTACTTTTCATGCGCAAGCCTTTAC
CTTGTTAGTTGGGAGCAGTGGTTCAGGAAAATCCAGCCTTTTTCAAGTCATTGCCCAAGTCAGTTCTCTTCCCTATAGTG
GTCAAGTCCTGATAGATGGGAGCGAGGTCAGTCAGCTTTCTATCATCGCACGTGTCCAGAAGGTTGGCATTCTCTTTCAA
AATCCCAATCATCAATTTACCATGGAGAACTTGTTTGAGGAGCTGATTTTCACCTTGGAGAATATCGGCTATCACCTTCA
GGAAATTGATTCTAAAATAGCAGAGGTTGTCCAGCAATGTCGTTGCGAGGCAATCTTACACCGTCCCATTCATCACCTAT
CAGGTGGGGAAAAGCAAAAAGCAGCGATGGCTGTCCTCTTTGCCATGAATCCTAGGGTATATCTCTTGGATGAGCCCTTC
GCTTCCATTGACCGCAAGAGCAGAATCGAGATATTGGAGATTCTAAAAGAGTTGGCTCTTGATGGGAAGACAGTTATTTT
GTGCGACCATGATTTATCTGACTATAAAGCCTATATCGACCATATGGTTGAGCTAAGAGACGGAAAACTAAGGGAAGTGT
TTCAAATCCCTTCCTATGAGATGACACAGGTTGCTTCAAAGGAAGTTGCTTCTAGCCCGGAACTATTCCATATGGATAGA
ACGACTTGTGAGTTTGGAAATCGCTCCCTCTTTTCGATTGCTGATTTTACATTTTACCAAGGAATTTCCTGTATCCTGGG
TGACAATGGTGTTGGGAAATCAACCCTCTTTCGGTCTATTCTTCAATTTCAAAAGTATAAGGGGCGCATTGCATGGAAGG
GGACAGTCCTGAAAAAGAAAAAGAGTTTGTACCGTGAACTGACGAGTATTGTTCAGGAAGCTGAGAAGCAGTTTATCCGA
GTCAGTCTGCGAGAGGAGCTTCAATTAGATGGACCTGATTCTGAAAGAAATCAGCGGATTTTTCAAGCTTTACGATATTT
TGATTTGGAGCAGGCAGTCGATAAGAGTCCCTATCAATTAAGTGGTGGTCAGCAAAAAATTCTTCAGCTCTTGACCATCT
TGACCAGTAAGGCTTCCGTGATCTTGCTAGATGAACCTTTTGCAGGTTTGGATGATAGAGCCTGCCATTATTTTTGCAAG
TGGATTGTGGAGGAGAGGAATCAAGGAAGAAGTTTTCTGCTCATTAGTCATCGTTTAGACCCTTTGATTTCTGTGGTTGA
TTATTGGATTGAGATGACTAGTCAGGGTCTTCGGCATGTGAAAGAAGTGACCATTACCAAACCACTTACATCTCAGAGTA
GCAATACCCAAGGGGAGGTGAGATAG

Upstream 100 bases:

>100_bases
ACTTGTGGTACGTTTTATTTCTGTTTATTTCTTCTGTACCATCTTGGTTCGTGCCATTGTCAAACTCTATCATCAGTTTG
CAACTGGAGGAAAAGCATAG

Downstream 100 bases:

>100_bases
TATGGTCAAAGTAGCAACCCAGACACCGATTATCAGTCTCTTCTTGCTGATTTTATCCTTGGAAACATCTTTCATTCCTT
CGATTGCTCTGAATCTTTCG

Product: ABC transporter ATP-binding protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVIAQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILFQ
NPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAAMAVLFAMNPRVYLLDEPF
ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDHMVELRDGKLREVFQIPSYEMTQVASKEVASSPELFHMDR
TTCEFGNRSLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKKKSLYRELTSIVQEAEKQFIR
VSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCK
WIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR

Sequences:

>Translated_461_residues
MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVIAQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILFQ
NPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAAMAVLFAMNPRVYLLDEPF
ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDHMVELRDGKLREVFQIPSYEMTQVASKEVASSPELFHMDR
TTCEFGNRSLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKKKSLYRELTSIVQEAEKQFIR
VSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCK
WIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR
>Mature_460_residues
GLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVIAQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILFQN
PNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAAMAVLFAMNPRVYLLDEPFA
SIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDHMVELRDGKLREVFQIPSYEMTQVASKEVASSPELFHMDRT
TCEFGNRSLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKKKSLYRELTSIVQEAEKQFIRV
SLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCKW
IVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR

Specific function: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system [H]

COG id: COG1122

COG function: function code P; ABC-type cobalt transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI171184400, Length=221, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI27477115, Length=193, Percent_Identity=28.4974093264249, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI27436953, Length=193, Percent_Identity=25.3886010362694, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI31657092, Length=198, Percent_Identity=26.2626262626263, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI42741659, Length=199, Percent_Identity=31.6582914572864, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI4505771, Length=196, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI9961252, Length=196, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI9961250, Length=196, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI153792144, Length=194, Percent_Identity=25.7731958762887, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI105990541, Length=194, Percent_Identity=24.7422680412371, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786345, Length=199, Percent_Identity=31.1557788944724, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI87081834, Length=208, Percent_Identity=34.1346153846154, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790739, Length=191, Percent_Identity=29.3193717277487, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787370, Length=208, Percent_Identity=28.8461538461538, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786803, Length=211, Percent_Identity=26.5402843601896, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081791, Length=197, Percent_Identity=28.4263959390863, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788761, Length=190, Percent_Identity=30.5263157894737, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1786398, Length=218, Percent_Identity=28.8990825688073, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788506, Length=454, Percent_Identity=23.568281938326, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789032, Length=195, Percent_Identity=29.2307692307692, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1787029, Length=206, Percent_Identity=27.1844660194175, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790467, Length=206, Percent_Identity=28.6407766990291, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788450, Length=200, Percent_Identity=27.5, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081709, Length=213, Percent_Identity=29.1079812206573, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787089, Length=207, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI145693107, Length=488, Percent_Identity=22.5409836065574, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786975, Length=465, Percent_Identity=23.010752688172, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786563, Length=246, Percent_Identity=26.4227642276423, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788225, Length=217, Percent_Identity=26.7281105990783, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787792, Length=449, Percent_Identity=23.6080178173719, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87082267, Length=178, Percent_Identity=26.9662921348315, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786253, Length=196, Percent_Identity=28.0612244897959, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789672, Length=190, Percent_Identity=26.8421052631579, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789873, Length=197, Percent_Identity=26.9035532994924, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788644, Length=180, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790162, Length=220, Percent_Identity=30.4545454545455, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786872, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789962, Length=228, Percent_Identity=27.6315789473684, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787712, Length=189, Percent_Identity=28.042328042328, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081782, Length=215, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787105, Length=211, Percent_Identity=27.4881516587678, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787547, Length=220, Percent_Identity=23.6363636363636, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789586, Length=213, Percent_Identity=27.2300469483568, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786703, Length=196, Percent_Identity=30.6122448979592, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48995001, Length=217, Percent_Identity=27.1889400921659, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789593, Length=193, Percent_Identity=27.979274611399, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789891, Length=142, Percent_Identity=32.3943661971831, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789991, Length=239, Percent_Identity=25.9414225941423, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17558664, Length=198, Percent_Identity=30.8080808080808, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71992290, Length=214, Percent_Identity=27.5700934579439, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146777, Length=224, Percent_Identity=28.125, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551702, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551700, Length=193, Percent_Identity=27.4611398963731, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=207, Percent_Identity=26.5700483091787, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320296, Length=410, Percent_Identity=23.9024390243902, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324498, Length=217, Percent_Identity=28.110599078341, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574744, Length=196, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI85724858, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI85724856, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24580547, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24580551, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24580549, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24580545, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221512771, Length=199, Percent_Identity=28.643216080402, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007184, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221500365, Length=196, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666092, Length=206, Percent_Identity=27.1844660194175, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136662, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24659289, Length=192, Percent_Identity=28.6458333333333, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 52432; Mature: 52301

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVIAQVSSLPYSGQVLIDG
CCCCHHHHHCCCCCCCCCCEEECEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECC
SEVSQLSIIARVQKVGILFQNPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQC
CCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
RCEAILHRPIHHLSGGEKQKAAMAVLFAMNPRVYLLDEPFASIDRKSRIEILEILKELAL
HHHHHHHHHHHHCCCCCHHHHHHEEEEECCCEEEEECCCHHHCCCHHHHHHHHHHHHHHC
DGKTVILCDHDLSDYKAYIDHMVELRDGKLREVFQIPSYEMTQVASKEVASSPELFHMDR
CCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEECCC
TTCEFGNRSLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKK
CHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHH
KSLYRELTSIVQEAEKQFIRVSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
SGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCKWIVEERNQGRSFLLISHRLD
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
PLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
GLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVIAQVSSLPYSGQVLIDG
CCCHHHHHCCCCCCCCCCEEECEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECC
SEVSQLSIIARVQKVGILFQNPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQC
CCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
RCEAILHRPIHHLSGGEKQKAAMAVLFAMNPRVYLLDEPFASIDRKSRIEILEILKELAL
HHHHHHHHHHHHCCCCCHHHHHHEEEEECCCEEEEECCCHHHCCCHHHHHHHHHHHHHHC
DGKTVILCDHDLSDYKAYIDHMVELRDGKLREVFQIPSYEMTQVASKEVASSPELFHMDR
CCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEECCC
TTCEFGNRSLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKK
CHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHH
KSLYRELTSIVQEAEKQFIRVSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
SGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCKWIVEERNQGRSFLLISHRLD
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
PLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]