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The map label for this gene is mtlD

Identifier: 116516528

GI number: 116516528

Start: 365538

End: 366674

Strand: Direct

Name: mtlD

Synonym: SPD_0363

Alternate gene names: 116516528

Gene position: 365538-366674 (Clockwise)

Preceding gene: 116515528

Following gene: 116516231

Centisome position: 17.86

GC content: 36.85

Gene sequence:

>1137_bases
ATGAAACATTCTGTTCATTTTGGTGCCGGTAATATCGGTCGTGGTTTTATAGGTGAAATTCTATTTAAAAATGGTTTCCA
TATTGATTTTGTGGATGTCAATAATCAGATAATTCATGCTCTAAATGAAAAGGGCAAGTATGAAATTGAAATTGCACAGA
AAGGACAGTCTCGTATAGAAGTAACTAATGTGGCTGGCATTAATAGCAAAGAACATCCTGAGCAAGTCATTGAAGCGATT
CAAAAGACGGATATTATTACTACTGCAATCGGACCTAATATACTCCCTTTTATCGCTGAACTTCTAGCCAAAGGAATCGA
AGCTCGCCGAGTTGCAGGGAATACACAGGTATTGGATGTTATGGCCTGTGAAAATATGATTGGCGGGTCTCAATTTCTTT
ATCAAGAAGTCAAGAAATATTTAAGTCCGGAAGGTTTGACATTTGCTGATAACTACATAGGTTTTCCAAATGCTGCAGTA
GACAGGATTGTTCCAGCACAAAGTCACGAAGATTCCCTTTTTGTTGTGGTCGAGCCCTTTAATGAATGGGTCGTGGAAAC
CAAGCGTCTTAAAAATCCAGATTTACGTCTAAAAGATGTGCATTATGAAGAAGATTTAGAACCCTTTATTGAGCGAAAAC
TTTTTTCAGTCAATTCTGGACATGCAACTTCAGCTTACATTGGTGCGCATTATGGTGCCAAGACAATTTTGGAAGCTCTT
CAAAATCCTAATATCAAATCTCGGATTGAATCTGTATTAGCTGAAATTCGGAGTCTCTTGATTGCCAAATGGAACTTTGA
TAAAAAAGAATTGGAGAATTATCACAAAGTCATTATAGAACGGTTTGAAAACCCTTTCATAGTGGACGAAGTTAGTCGCG
TAGCTCGTACTCCAATCCGAAAATTAGGCTATAATGAACGATTCATCCGGCCGATACGTGAATTGAAAGAACTCAGTTTG
TCATATAAAAACCTACTTAAAACAGTTGGCTATGCCTTTGACTATCGCGATGTAAATGATGAAGAAAGTATTCGATTAGG
TGAATTGTTGGCTAAACAATTAGTCAAAGATGTTGTTATACAAGTTACAGGTTTAGACGACCAAGAATTGATTGAGCAAA
TTGTAGAGTATATTTAA

Upstream 100 bases:

>100_bases
AAAGAGGAAGTATTGCGCTTATTTGATGCTGTTGAATAATTGAATTTCGTCATTTGTCATCTAGTATATATGTCCCTCAA
ATAGGAAAAGGAGAAATTGA

Downstream 100 bases:

>100_bases
TCTTTTTCGAAAATCTCTTCAAATCAGGTTAGCATCGCTTTGTCTTAGGCATATGTTACTGACTTCGTCAGTTCTATCTA
CAACCTCAAAGCAGTGCTTT

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAI
QKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQVLDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSL
SYKNLLKTVGYAFDYRDVNDEESIRLGELLAKQLVKDVVIQVTGLDDQELIEQIVEYI

Sequences:

>Translated_378_residues
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAI
QKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQVLDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSL
SYKNLLKTVGYAFDYRDVNDEESIRLGELLAKQLVKDVVIQVTGLDDQELIEQIVEYI
>Mature_378_residues
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAI
QKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQVLDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAV
DRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSL
SYKNLLKTVGYAFDYRDVNDEESIRLGELLAKQLVKDVVIQVTGLDDQELIEQIVEYI

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=376, Percent_Identity=35.6382978723404, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1790779, Length=258, Percent_Identity=24.4186046511628, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788497, Length=277, Percent_Identity=25.2707581227437, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787823, Length=246, Percent_Identity=23.5772357723577, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324401, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320765, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_STRP2 (Q04M75)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_815873.1
- ProteinModelPortal:   Q04M75
- STRING:   Q04M75
- EnsemblBacteria:   EBSTRT00000020568
- GeneID:   4443079
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0363
- eggNOG:   COG0246
- GeneTree:   EBGT00050000029461
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 42992; Mature: 42992

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIE
CCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCEEEEEECCCCCEEE
VTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQVLDV
EEEEECCCCCCCHHHHHHHHHHHHHEHHHCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHH
MACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAVDRIVPAQSHEDSLFVVVEPF
HHHHHHCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCCCCCCEEEEEECH
NEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
HHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHH
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIR
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHH
KLGYNERFIRPIRELKELSLSYKNLLKTVGYAFDYRDVNDEESIRLGELLAKQLVKDVVI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QVTGLDDQELIEQIVEYI
HHCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIE
CCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCEEEEEECCCCCEEE
VTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQVLDV
EEEEECCCCCCCHHHHHHHHHHHHHEHHHCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHH
MACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAVDRIVPAQSHEDSLFVVVEPF
HHHHHHCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHCCCCCCCCCCEEEEEECH
NEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEAL
HHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHH
QNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIR
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHH
KLGYNERFIRPIRELKELSLSYKNLLKTVGYAFDYRDVNDEESIRLGELLAKQLVKDVVI
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QVTGLDDQELIEQIVEYI
HHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA