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The map label for this gene is map [H]

Identifier: 116516526

GI number: 116516526

Start: 984439

End: 985299

Strand: Direct

Name: map [H]

Synonym: SPD_0970

Alternate gene names: 116516526

Gene position: 984439-985299 (Clockwise)

Preceding gene: 116517139

Following gene: 116515413

Centisome position: 48.11

GC content: 41.7

Gene sequence:

>861_bases
ATGATAACATTAAAATCAGCTCGTGAAATCGAAGCTATGGACAAGGCTGGTGATTTTCTAGCAAGTATTCATATAGGCTT
ACGTGATTTGATTAAGCCAGGCGTAGATATGTGGGAAGTTGAAGAATATGTCCGCCGTCGTTGTAAAGAAGAAAATTTCC
TTCCACTTCAGATTGGGGTTGACGGTGCCATGATGGACTATCCTTATGCTACCTGTTGCTCTCTTAACGATGAAGTGGCT
CACGCTTTCCCTCGTCATTATATCTTGAAAGATGGTGATTTGCTCAAAGTTGATATGGTTTTGGGAGGTCCCATTGCTAA
ATCTGACCTAAATGTCTCAAAATTAAACTTCAACAATGTTGAACAAATGAAAAAATACACTCAGAGCTATTCTGGTGGTT
TAGCAGACTCATGTTGGGCTTATGCTGTTGGTACACCGTCCGAAGAAGTCAAAAACTTGATGGATGTAACCAAAGAAGCT
ATGTACAAGGGTATTGAGCAAGCTGTTGTTGGAAATCGTATCGGTGATATCGGTGCGGCTATTCAAGAATACGCTGAAAG
TCGTGGTTACGGTGTAGTGCGTGATTTGGTTGGTCATGGTGTTGGCCCAACTATGCACGAAGAACCAATGGTTCCTAACT
ATGGTATTGCAGGTCGTGGACTCCGTCTTCGTGAAGGAATGGTCTTAACCATTGAACCAATGATCAATACAGGCGATTGG
GAAATTGATACAGATATGAAAACTGGTTGGGCGCATAAGACCATTGACGGTGGATTGTCATGTCAGTATGAACACCAATT
TGTCATTACGAAAGATGGACCTGTTATCTTGACTAGCCAAGGTGAAGAAGGAACTTATTAA

Upstream 100 bases:

>100_bases
GAGACGGTCAGCTATAATTGATTACGATATTTATCATGGTCACCAGATTGTTTCAAAAGCAAATGTGACTGTTAAAATTA
ATTAGAAACTAGGAGAAAAG

Downstream 100 bases:

>100_bases
TAAAAAGTGAAAAGACTACTGGAAGTTTATTTTGATAAAAAATCCAGTAGATCTTTTCATAATAAAACGCATTGTATCAA
GTGTTAGGGGCTGATATCAT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVA
HAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDW
EIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY

Sequences:

>Translated_286_residues
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVA
HAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDW
EIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
>Mature_286_residues
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVA
HAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDW
EIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=279, Percent_Identity=29.0322580645161, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI40385867, Length=283, Percent_Identity=25.0883392226148, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786364, Length=288, Percent_Identity=33.6805555555556, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71996291, Length=249, Percent_Identity=28.5140562248996, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323273, Length=255, Percent_Identity=28.6274509803922, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355531, Length=274, Percent_Identity=28.8321167883212, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24583427, Length=275, Percent_Identity=25.8181818181818, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 31650; Mature: 31650

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGV
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECC
DGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNV
CCCEECCCCHHHHCCCHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCCCCEEECCCCCH
EQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEAMYKGIEQAVVGNRIGDIGAA
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDW
HHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCCE
EIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
EEECCCCCCCCCCCCCCCCEEEEECEEEEECCCCEEEEECCCCCCC
>Mature Secondary Structure
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGV
CEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECC
DGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNV
CCCEECCCCHHHHCCCHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCCCCEEECCCCCH
EQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEAMYKGIEQAVVGNRIGDIGAA
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
IQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDW
HHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCCE
EIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
EEECCCCCCCCCCCCCCCCEEEEECEEEEECCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]