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The map label for this gene is pdp [H]

Identifier: 116516475

GI number: 116516475

Start: 748002

End: 749279

Strand: Direct

Name: pdp [H]

Synonym: SPD_0736

Alternate gene names: 116516475

Gene position: 748002-749279 (Clockwise)

Preceding gene: 116516099

Following gene: 116517157

Centisome position: 36.56

GC content: 42.96

Gene sequence:

>1278_bases
ATGAGAGCAGTTGATTTAATACAAAAAAAACGAGACGGTCAAGAACTGACTTCAAGTGAAATTGAATGGCTGGTAGAAGG
CTATGTGTCAGGAACTGTTCCTGATTATCAGATGTCTGCCTTTGCTATGGCTGTTTATTTTAAAGGAATGACGACTCGAG
AAATCTCTGATTTAACGATGAATATGGTTAAGACTGGGCAAGAGTTTGACCTGTCAGCCATTGATGGTGTGAAAGTTAAC
AAGCATTCTACTGGTGGTGTCGGCGATAAGGTAACCTTGATTTTAGTTCCTCTTGTTGCTAGCTTCGGTGTGCCTGTAGC
AAAAATGAGTGGTCGTGGTCTTGGCCATACAGGCGGAACAATTGATAAATTGGAGTCCATTAAGGGCTATCAAGTAGAAC
GTAGTCAAGAGGATTTTATTCGTCAGGTTCAGGATATTGGAGTATCTGTCATTGGGCAATCAGACCAGCTGGTCAAAGCA
GATAAGCTTCTCTATGCCCTTCGTGATGTGACCGCAACTGTCGACACGATTCCTTTGATTGCGAGTTCGGTGATGAGCAA
GAAAATTGCGGCAGGGGCGGATGCTATTTTGCTAGACGTGACTGTCGGTGAGGGTGCCTTCATGAAGACGGTTGATGAGG
CGCGTGAGTTGGCTCAAACTATGGTAGATCTTGGTAAGGTTGTTGGACGGAAGACAGTAGCAGTGATTACGGATATGAGC
CAGCCTTTGGGACGAGCGATTGGAAATCGTCTGGAAATCCTTGAAGCATTGGAGATTTTGCAAGGTCAAGGACGTCAGGA
TATTACCCACTTTATTTGTGAATTGGCTCAAATTATGCTTGGTTTGGCAAATGTTAACAAAACTGTTGAAGAAGTTCGCC
AACATCTTGAGAATGGTCAAGCACTGGCTAAGTTTGAGGAAATGGTGCAAGCCCAAGGTGGAGACTTGGAAGACCTCTAT
CGTCCTGTAAATGTAGCTCATGTGGTGGAAATCCCTGCTCAGGAAACGGGTGTCATTTCAGCTCTTCCAGCTATGGACTT
TGGTCTTTATGCCATGAGGCTGGGTGCTGGTCGTGCAGTTAAGTCTGATGCCTTGGACTATGAAACAGGAATTGTTTTTG
AAAAGAAGATTGGAGACTCCGTTCAAAAGGGTGAAATTGTTGCAAAAGTATACACAAATGAAAAAATTCCACCTCAACTA
GTTACAGATTTCCAAAAATGTGTTAAAATAAGTGATGAAGTAAAAAAAATCCGTGAAATTGTAGAAATCATCTCCTAA

Upstream 100 bases:

>100_bases
AAGGGGCTCCAAGTGCTAAGTCCAAGATGGAGGATGTGTTTGGTAATTGTGAAATCCTTAAAAAAGACAAGGGATACTAT
ATCCTTAGAAGTGTGAAAGA

Downstream 100 bases:

>100_bases
ATGGAGGGAAAACCGAAATGAAATTAAATAAATATATAGATCATACGCTTTTAAAACAAGATGCAAAGAAAAAACAAATT
GATAGTTTGTTGTCTGAGGC

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVN
KHSTGGVGDKVTLILVPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLY
RPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYTNEKIPPQL
VTDFQKCVKISDEVKKIREIVEIIS

Sequences:

>Translated_425_residues
MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVN
KHSTGGVGDKVTLILVPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLY
RPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYTNEKIPPQL
VTDFQKCVKISDEVKKIREIVEIIS
>Mature_425_residues
MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVN
KHSTGGVGDKVTLILVPLVASFGVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLY
RPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAVKSDALDYETGIVFEKKIGDSVQKGEIVAKVYTNEKIPPQL
VTDFQKCVKISDEVKKIREIVEIIS

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=38.0835380835381, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=38.0835380835381, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=38.0835380835381, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=38.3663366336634, Blast_Score=266, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46160; Mature: 46160

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTM
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NMVKTGQEFDLSAIDGVKVNKHSTGGVGDKVTLILVPLVASFGVPVAKMSGRGLGHTGGT
HHHHCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKADKLLYALRDVTATVDTIPLI
HHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHH
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAV
HHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
KSDALDYETGIVFEKKIGDSVQKGEIVAKVYTNEKIPPQLVTDFQKCVKISDEVKKIREI
HHCCCCCCCCCEEEHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VEIIS
HHHHC
>Mature Secondary Structure
MRAVDLIQKKRDGQELTSSEIEWLVEGYVSGTVPDYQMSAFAMAVYFKGMTTREISDLTM
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NMVKTGQEFDLSAIDGVKVNKHSTGGVGDKVTLILVPLVASFGVPVAKMSGRGLGHTGGT
HHHHCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
IDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKADKLLYALRDVTATVDTIPLI
HHHHHHCCCCCCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELAQTMVDLGKVVGRKTVAVITDMS
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHH
QPLGRAIGNRLEILEALEILQGQGRQDITHFICELAQIMLGLANVNKTVEEVRQHLENGQ
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQETGVISALPAMDFGLYAMRLGAGRAV
HHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
KSDALDYETGIVFEKKIGDSVQKGEIVAKVYTNEKIPPQLVTDFQKCVKISDEVKKIREI
HHCCCCCCCCCEEEHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VEIIS
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA