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The map label for this gene is dltA

Identifier: 116516471

GI number: 116516471

Start: 1979968

End: 1981518

Strand: Reverse

Name: dltA

Synonym: SPD_2005

Alternate gene names: 116516471

Gene position: 1981518-1979968 (Counterclockwise)

Preceding gene: 116516054

Following gene: 116515437

Centisome position: 96.84

GC content: 44.1

Gene sequence:

>1551_bases
GTGTCAAATAAACCAATAGCAGATATGATTGAAACCATTGAGCATTTTGCTCAGACACAGCCTAGCTATCCTGTCTATAA
TGTTTTGGGGCAGGAACACACTTATGGCGATTTAAAGGCTGATTCGGATAGTTTGGCTGCAGTCATTGACCAACTAGGCT
TGCCTGAGAAGTCTCCTGTGGTTGTTTTTGGTGGCCAAGAATATGAAATGTTGGCAACCTTTGTAGCGCTGACTAAGTCA
GGTCATGCCTACATTCCAATTGATAGCCATTCGGCCTTGGAGCGAGTTTCAGCTATTTTAGAAGTAGCAGAGCCAAGCTT
GATTATTGCCATTTCAGCCTTTCCCTTGGAGCAGGTTTCTACACCAATGATAAATCTAGCTCAGGTTCAAGAAGCCTTTG
CCCAAGGGAATAACTATGAAATCACGCATCCAGTCAAGGGAGATGATAATTACTACATTATCTTTACTTCTGGTACGACT
GGTAAGCCTAAGGGAGTGCAGATTTCACATGATAATCTCCTCAGCTTTACAAACTGGATGATTACGGATAAGGAATTTGC
GACACCGAGTCGTCCGCAAATGCTGGCACAGCCACCTTATTCTTTTGACTTGTCTGTCATGTATTGGGCACCGACCTTGG
CACTTGGTGGTACGCTTTTCACTCTTCCTTCAGTCATCACTCAGGACTTTAAGCAACTCTTTGCGGCTATCTTTTCATTG
CCAATCGCTATCTGGACATCAACACCATCCTTTGCAGATATGGCCATGTTGTCTGAATACTTCAACAGTGAGAAAATGCC
TGGAATCACGCATTTCTACTTTGATGGTGAAGAATTGACGGTCAAAACAGCTCAAAAACTGCGCGAGCGTTTCCCAAATG
CCCGTATCATCAATGCTTACGGCCCAACAGAAGCGACAGTAGCTCTGTCAGCAGTTGCCGTGACAGACGAGATGTTAGCG
ACTCTCAAACGCCTACCAATCGGCTATACCAAGGCTGATTCTCCAACCTTTATCATTGACGAGGAAGGAAATAAACTGCC
AAATGGTGAGCAGGGAGAAATCATTGTTTCTGGGCCAGCTGTTTCAAAAGGTTATATGAACAATCCTGAAAAAACAGCAG
AAGCCTTCTTTGAGTTTGAAGATCTGCCAGCCTATCACACAGGCGATGTGGGAACCATGACAGATGAGGGCTTGCTTCTC
TACGGCGGACGCATGGACTTCCAGATTAAGTTTAACGGTTACCGCATTGAGTTAGAAGATGTCTCTCAAAACCTCAACAA
GTCTCGCTTTATCGAATCTGCTGTCGCAGTACCGCGCTATAACAAGGACCACAAGGTACAAAATCTATTGGCTTATGTCA
TCTTAAAAGACGGTGTTCGTGAGCAGTTTGAGCGAGATATCGATATTACCAAGGCCATCAAGGAAGACCTGACAGACATC
ATGATGTCCTATATGATGCCATCTAAATTCCTTTACCGAGACAGTTTGCCACTAACTCCAAATGGAAAGATTGACATCAA
AGGATTGATTAACGAGGTGAATAAGAGATGA

Upstream 100 bases:

>100_bases
TTCTTATCTTTCTAGGGCTGCTTTACTTCTTTAGCTATCTTGGTCAGGGTCAAGGAAGCTTTATCTATAATGAATTTTAA
CTTGAAGGAGAATCCCTATT

Downstream 100 bases:

>100_bases
TGGAGTTTTTTCAACAGCTTCCTCATTTAGAGCCATATGGCAATCCTCAGTATTTTGTTTATGTGATTGCTGCAACCTTG
CCCATCTTTATAGGTCTCTT

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKS
GHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLA
TLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLL
YGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR

Sequences:

>Translated_516_residues
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKS
GHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLA
TLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLL
YGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
>Mature_515_residues
SNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSG
HAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTG
KPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSLP
IAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLAT
LKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLLY
GGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDIM
MSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily

Homologues:

Organism=Homo sapiens, GI115511026, Length=386, Percent_Identity=28.7564766839378, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI45580730, Length=376, Percent_Identity=25.531914893617, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI42544132, Length=540, Percent_Identity=24.0740740740741, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38505220, Length=389, Percent_Identity=26.7352185089974, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156151445, Length=554, Percent_Identity=22.9241877256318, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786801, Length=496, Percent_Identity=26.4112903225806, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786810, Length=512, Percent_Identity=21.875, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI145693145, Length=408, Percent_Identity=23.7745098039216, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788107, Length=557, Percent_Identity=22.262118491921, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789201, Length=284, Percent_Identity=25.3521126760563, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32563687, Length=488, Percent_Identity=24.1803278688525, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=489, Percent_Identity=23.721881390593, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=360, Percent_Identity=25.8333333333333, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=424, Percent_Identity=26.4150943396226, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17556356, Length=463, Percent_Identity=27.4298056155508, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=544, Percent_Identity=22.7941176470588, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994703, Length=544, Percent_Identity=22.7941176470588, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994694, Length=544, Percent_Identity=22.7941176470588, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=433, Percent_Identity=24.9422632794457, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=412, Percent_Identity=24.0291262135922, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=560, Percent_Identity=25, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319699, Length=373, Percent_Identity=28.686327077748, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648676, Length=462, Percent_Identity=26.6233766233766, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI18859661, Length=372, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355181, Length=375, Percent_Identity=23.4666666666667, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356441, Length=412, Percent_Identity=20.3883495145631, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DLTA_STRP2 (Q04HZ7)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_817391.1
- ProteinModelPortal:   Q04HZ7
- SMR:   Q04HZ7
- STRING:   Q04HZ7
- EnsemblBacteria:   EBSTRT00000019635
- GeneID:   4442941
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_2005
- eggNOG:   COG1020
- GeneTree:   EBGT00050000027070
- HOGENOM:   HBG320748
- OMA:   MIATIEN
- ProtClustDB:   PRK04813
- GO:   GO:0005737
- HAMAP:   MF_00593
- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072
- PANTHER:   PTHR11968:SF34
- TIGRFAMs:   TIGR01733
- TIGRFAMs:   TIGR01734

Pfam domain/function: PF00501 AMP-binding

EC number: =6.1.1.13

Molecular weight: Translated: 57428; Mature: 57297

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPV
CCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
VVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVS
EEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHC
TPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGKPKGVQISHDNLLSFTNWM
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHEE
ITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
EECHHCCCCCCCCEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAY
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECC
GPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
VSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELED
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEHHH
VSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
HHHHHCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC
>Mature Secondary Structure 
SNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPV
CCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
VVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVS
EEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHC
TPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGKPKGVQISHDNLLSFTNWM
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHEE
ITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSL
EECHHCCCCCCCCEECCCCCCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
PIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAY
CEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHHHHHCCCCEEEECC
GPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCC
VSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELED
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEHHH
VSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDI
HHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
HHHHHCCCHHHCCCCCCCCCCCCEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA