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The map label for this gene is msrAB1

Identifier: 116516363

GI number: 116516363

Start: 1221142

End: 1222080

Strand: Reverse

Name: msrAB1

Synonym: SPD_1193

Alternate gene names: 116516363

Gene position: 1222080-1221142 (Counterclockwise)

Preceding gene: 116517101

Following gene: 116516223

Centisome position: 59.73

GC content: 43.98

Gene sequence:

>939_bases
ATGGCAGAAATTTATCTAGCAGGTGGTTGTTTTTGGGGCCTAGAGGAATATTTTTCACGCATTTCTGGAGTGCTAGAAAC
CAGTGTTGGCTACGCTAATGGTCAAGTCGAAACGACCAATTACCAGTTGCTCAAGGAAACAGACCATGCAGAAACGGTCC
AAGTGATTTACGATGAGAAGGAAGTGTCACTCAGAGAGATTTTACTTTATTATTTCCGAGTTATCGATCCTCTATCTATC
AATCAACAAGGGAATGACCGTGGTCGCCAATATCGAACTGGGATTTATTATCAGGATGAAGCAGATTTGCCAGCTATCTA
CACAGTGGTGCAGGAGCAGGAACGCATGCTGGGTCGAAAGATTGCAGTAGAAGTGGAGCAATTACGCCACTACATTCTGG
CTGAAGACTACCACCAAGACTATCTCAGGAAGAATCCTTCAGGTTACTGTCATATCGATGTGACCGATGCTGATAAGCCA
TTGATTGATGCAGCAAACTATGAAAAGCCTAGTCAAGAGGTGTTGAAGGCCAGTCTATCTGAAGAGTCTTATCGTGTCAC
ACAAGAAGCTGCTACAGAGGCTCCATTTACCAATGCCTATGACCAAACCTTTGAAGAGGGGATTTATGTAGATATTACGA
CAGGTGAGCCACTCTTTTTTGCCAAGGATAAGTTTGCTTCAGGTTGTGGTTGGCCAAGTTTTAGCCGTCCGATTTCCAAA
GAGTTGATTCATTATTACAAGGATCTGAGCCATGGAATGGAGCGAATTGAAGTTCGTTCTCGTTCAGGCAGTGCTCACTT
GGGTCATGTTTTCACAGATGGACCGCGGGAGTTAGGCGGCCTCCGTTACTGTATCAATTCTGCTTCTTTACGCTTTGTGG
CCAAGGATGAGATGGAAAAAGCAGGATATGGCTATCTATTGCCTTACTTAAACAAATAA

Upstream 100 bases:

>100_bases
GACGAAGTCAGTAACCATACCTACGGTAAGGTGACGCTGACGTGGTTTGAAGAGATTTTCGAAGAGTATTAGTTAAAAAC
GTGATAAAGGAGAAATAAAG

Downstream 100 bases:

>100_bases
AACAGAGAGTGGGGCTTCCCACTTTCTTCATTTCTAGAATATGAATAGAAGGGATTTATGAAACACCTATTATCTTACTT
CAAACCCTACATCAAGGAAT

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSI
NQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK

Sequences:

>Translated_312_residues
MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSI
NQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK
>Mature_311_residues
AEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSIN
QQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPL
IDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISKE
LIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI301336162, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI73089054, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI37620216, Length=140, Percent_Identity=45, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=35.2201257861635, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=35.2201257861635, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI117606353, Length=121, Percent_Identity=42.1487603305785, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI208609993, Length=129, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788077, Length=132, Percent_Identity=52.2727272727273, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790665, Length=148, Percent_Identity=37.1621621621622, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=132, Percent_Identity=46.2121212121212, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17553450, Length=132, Percent_Identity=46.2121212121212, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=39.1025641025641, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=38.3333333333333, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221378664, Length=132, Percent_Identity=44.6969696969697, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45553335, Length=127, Percent_Identity=44.0944881889764, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356369, Length=127, Percent_Identity=44.0944881889764, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221378662, Length=139, Percent_Identity=42.4460431654676, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645799, Length=127, Percent_Identity=44.0944881889764, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645804, Length=138, Percent_Identity=40.5797101449275, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645801, Length=138, Percent_Identity=40.5797101449275, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24664627, Length=139, Percent_Identity=32.3741007194245, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=33.0935251798561, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664631, Length=139, Percent_Identity=31.6546762589928, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSAB1_STRPN (P0A3Q9)

Other databases:

- EMBL:   AE005672
- PIR:   H95157
- RefSeq:   NP_345817.1
- PDB:   3E0M
- PDBsum:   3E0M
- ProteinModelPortal:   P0A3Q9
- EnsemblBacteria:   EBSTRT00000026092
- GeneID:   931912
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_1359
- TIGR:   SP_1359
- GeneTree:   EBGT00050000027538
- HOGENOM:   HBG715255
- OMA:   KTDERVI
- ProtClustDB:   CLSK884075
- BioCyc:   SPNE170187-1:SP_1359-MONOMER
- BRENDA:   1.8.4.11
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- HAMAP:   MF_01401
- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00401
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01625 PMSR; PF01641 SelR; SSF55068 MsrA; SSF51316 Mss4_like

EC number: =1.8.4.11; =1.8.4.12

Molecular weight: Translated: 35703; Mature: 35572

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHAETVQVIYDEK
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCEEEEEECCC
EVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEECCCCCHHHHHHHHHHHHHHHHH
IAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPLIDAANYEKPSQEVLKASLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHC
EESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
HHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHH
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEK
HHHHHHHHHHHHHHHHHHHCCCCCCEECCEECCCHHHHHHHHHHHCCCCEEEEEHHHHHH
AGYGYLLPYLNK
CCCCEECCCCCC
>Mature Secondary Structure 
AEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHAETVQVIYDEK
CEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCEEEEEECCC
EVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEADLPAIYTVVQEQERMLGRK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEECCCCCHHHHHHHHHHHHHHHHH
IAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKPLIDAANYEKPSQEVLKASLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHC
EESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPISK
HHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHH
ELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEK
HHHHHHHHHHHHHHHHHHHCCCCCCEECCEECCCHHHHHHHHHHHCCCCEEEEEHHHHHH
AGYGYLLPYLNK
CCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11463916