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The map label for this gene is manA [H]

Identifier: 116516277

GI number: 116516277

Start: 661064

End: 662008

Strand: Direct

Name: manA [H]

Synonym: SPD_0641

Alternate gene names: 116516277

Gene position: 661064-662008 (Clockwise)

Preceding gene: 116517078

Following gene: 116517044

Centisome position: 32.31

GC content: 43.07

Gene sequence:

>945_bases
ATGTCAGAACCATTATTTTTACAATCAGTTATGCAAGAAAAAATCTGGGGTGGTACCAAGCTACGTGATGAGTTTGGCTA
CGACATCCCAAGTGAAAAAGTCGGAGAGTACTGGGCTATCTCAGCTCATCTAAATGGTGTTTCTAAAGTTGCCAATGGTC
GTTACGAGGGAACAGATCTTGCTACTTTGTATGCGGAACACCGTGAATTATTTGGCAATCGTCCAGAACCTGTATTTCCA
CTTTTGACCAAGATCCTCGATGCCAACGACTGGCTCAGTGTCCAAGTTCACCCAGACGATGCTTATGGACTCGAGCATGA
AGGCGAACTTGGAAAAACAGAATGTTGGTACATCATTGCAGCAGATGAAGGTTCAGAGATTATCTACGGTCACAATGCCA
AGTCAAAAGAAGAACTCCGCCAGCAAATCGAGGATAAGAACTGGGATGCGCTGTTGACAAAAGTGCCAGTTAAAGCAGGA
GATTTCTTCTATGTACCAAGCGGTACCATGCACGCTATCGGGGCGGGTATCTTGATTCTTGAAACCCAGCAGTCTAGCGA
TACCACTTACCGTGTCTATGACTTTGACCGTAAGGATGACAAGGGCAATTTACGTGAACTTCACCTTGAAAAATCTATCG
ATGTCTTGAACATTGGTGAACCCGCAAATAGCCGTCCAGTGACAATCAAAGCAGATGATCTACGTTCCACTCTCCTTGTA
TCCAATGATTTCTTCGCAGTTTACAAATGGGAAATTACTGGAAAAGTTAACTTTGAAAAGACAGCTGACTACAGCTTGTT
GAGTGTCTTGGCTGGTCAAGGTCAACTAACTGTTGACGGGAAAAACTATCCAATCCAAAAAGGGAGACACTTTATCCTAC
CAAGTGATGTTGAATCTTGGACTCTAGAAGGGCAAGATTTAGAATTAATTGTTAGTCATCCATAA

Upstream 100 bases:

>100_bases
TTATAAAATCTTCTCCCTGCTTTATAAGATGTAAAAAAGAGTTCAAATGGAACTCTTTTTTTGCTATAATGAGGGGAGAA
AAATCAGACAGGAGATTAAG

Downstream 100 bases:

>100_bases
AAAAGAAAGGACCTGAGTTCATTACTCAAGTCCTTTTGATTACATAAATTGGGCGATGAAGACCACGATGATGATTGGAA
TGACGAAACGAAGAAGGAAG

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFP
LLTKILDANDWLSVQVHPDDAYGLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAG
DFFYVPSGTMHAIGAGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTIKADDLRSTLLV
SNDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP

Sequences:

>Translated_314_residues
MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFP
LLTKILDANDWLSVQVHPDDAYGLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAG
DFFYVPSGTMHAIGAGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTIKADDLRSTLLV
SNDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP
>Mature_313_residues
SEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPL
LTKILDANDWLSVQVHPDDAYGLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAGD
FFYVPSGTMHAIGAGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTIKADDLRSTLLVS
NDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESWTLEGQDLELIVSHP

Specific function: Unknown

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR014628
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 35367; Mature: 35236

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDL
CCCCHHHHHHHHHHHCCCCEEHHHHCCCCCHHHCCCEEEEEECCCCHHHHHCCCCCCCHH
ATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAYGLEHEGELGKTECWYIIA
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEE
ADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAGDFFYVPSGTMHAIGAGILIL
ECCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCHHHCCCCEEEE
ETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTIKADDLRSTLLV
EECCCCCCEEEEEECCCCCCCCCCEEEEHHCCCCEEECCCCCCCCCEEEECCCCCEEEEE
SNDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESW
ECCEEEEEEEEEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCHHCCCEEEECCCCCCE
TLEGQDLELIVSHP
EECCCCEEEEEECC
>Mature Secondary Structure 
SEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHLNGVSKVANGRYEGTDL
CCCHHHHHHHHHHHCCCCEEHHHHCCCCCHHHCCCEEEEEECCCCHHHHHCCCCCCCHH
ATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAYGLEHEGELGKTECWYIIA
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEE
ADEGSEIIYGHNAKSKEELRQQIEDKNWDALLTKVPVKAGDFFYVPSGTMHAIGAGILIL
ECCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCCCHHHCCCCEEEE
ETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNIGEPANSRPVTIKADDLRSTLLV
EECCCCCCEEEEEECCCCCCCCCCEEEEHHCCCCEEECCCCCCCCCEEEECCCCCEEEEE
SNDFFAVYKWEITGKVNFEKTADYSLLSVLAGQGQLTVDGKNYPIQKGRHFILPSDVESW
ECCEEEEEEEEEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCHHCCCEEEECCCCCCE
TLEGQDLELIVSHP
EECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8293960; 12397186 [H]