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The map label for this gene is cps2L [H]

Identifier: 116516051

GI number: 116516051

Start: 327793

End: 328662

Strand: Direct

Name: cps2L [H]

Synonym: SPD_0328

Alternate gene names: 116516051

Gene position: 327793-328662 (Clockwise)

Preceding gene: 116517147

Following gene: 116517185

Centisome position: 16.02

GC content: 42.87

Gene sequence:

>870_bases
ATGAAAGGTATTATTCTTGCGGGTGGCTCAGGTACCCGTCTGTATCCACTTACTCGAGCTACATCGAAACAGCTGATGCC
GGTTTATGATAAACCCATGATTTACTATCCTCTGTCAACTTTGATGTTGGCGGGTATTAAGGATATTTTGATTATTTCAA
CGCCACAGGATTTGCCGCGCTTTAAGGACTTGCTCTTGGATGGTTCCGAATTTGGGATCAGACTTTCCTATGCGGAACAG
CCTAGTCCAGATGGCCTTGCTCAGGCCTTTCTTATCGGTGAGGATTTTATTGGTGACGATAGCGTTGCTTTAATCTTGGG
TGACAATATTTATCACGGTCCAGGTTTGAGCAAGATGCTCCAAAAAACTGTTTCGAAAGAAAAGGGTGCGACTGTTTTTG
GTTACCAAGTGAAGGATCCAGAACGCTTTGGTGTTGTAGAATTTGATGAAAATATGAATGCTATTTCCATAGAAGAAAAA
CCAGAGTGTCCTCGCTCCAACTATGCAGTGACAGGACTGTATTTCTATGATAACGATGTTGTCGAAATTGCCAAGAGTAT
CAAACCAAGTGCTCGTGGTGAGTTAGAAATCACAGATGTCAACAAGGCTTACTTGGATCGTGGTAATTTATCTGTCGAAG
TCATGGGACGTGGCTTTGCTTGGCTTGATACAGGAACCCATGAAAGCTTGTTGGAAGCCTCTCAATATATTGAAACGGTT
CAACGCATGCAAAATGTTCAAGTTGCCAATTTGGAAGAAATCGCCTATCGCATGGGTTATATTAGTCGTGAAGATGTGCT
GGAGTTGGCGCAACCTCTTAAGAAGAATGAATACGGACAGTATCTGCTCCGTTTGATTGGAGAAGTCTAG

Upstream 100 bases:

>100_bases
GTTTAGCAGATTATAAATATTAGTGGTGATTGAACGGATACTTAGTGTAGTAGAGGAAGAATTTAGTAATTAAAAAACAA
CGAAGAAAGGTTATTTCATT

Downstream 100 bases:

>100_bases
ATGACAGATAATTTTTTCGGAAAAATACTTGCGGTGCGTAAAATTGATGCCATTCCAGGTATGTTAGAGTTTGATATCCC
AGTTCATGGTGACAATCGTG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKGIILAGGSGTRLYPLTRATSKQLMPVYDKPMIYYPLSTLMLAGIKDILIISTPQDLPRFKDLLLDGSEFGIRLSYAEQ
PSPDGLAQAFLIGEDFIGDDSVALILGDNIYHGPGLSKMLQKTVSKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
PECPRSNYAVTGLYFYDNDVVEIAKSIKPSARGELEITDVNKAYLDRGNLSVEVMGRGFAWLDTGTHESLLEASQYIETV
QRMQNVQVANLEEIAYRMGYISREDVLELAQPLKKNEYGQYLLRLIGEV

Sequences:

>Translated_289_residues
MKGIILAGGSGTRLYPLTRATSKQLMPVYDKPMIYYPLSTLMLAGIKDILIISTPQDLPRFKDLLLDGSEFGIRLSYAEQ
PSPDGLAQAFLIGEDFIGDDSVALILGDNIYHGPGLSKMLQKTVSKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
PECPRSNYAVTGLYFYDNDVVEIAKSIKPSARGELEITDVNKAYLDRGNLSVEVMGRGFAWLDTGTHESLLEASQYIETV
QRMQNVQVANLEEIAYRMGYISREDVLELAQPLKKNEYGQYLLRLIGEV
>Mature_289_residues
MKGIILAGGSGTRLYPLTRATSKQLMPVYDKPMIYYPLSTLMLAGIKDILIISTPQDLPRFKDLLLDGSEFGIRLSYAEQ
PSPDGLAQAFLIGEDFIGDDSVALILGDNIYHGPGLSKMLQKTVSKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
PECPRSNYAVTGLYFYDNDVVEIAKSIKPSARGELEITDVNKAYLDRGNLSVEVMGRGFAWLDTGTHESLLEASQYIETV
QRMQNVQVANLEEIAYRMGYISREDVLELAQPLKKNEYGQYLLRLIGEV

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=239, Percent_Identity=25.9414225941423, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI11761619, Length=253, Percent_Identity=24.901185770751, Blast_Score=71, Evalue=9e-13,
Organism=Escherichia coli, GI1788351, Length=284, Percent_Identity=69.0140845070423, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=65.7342657342657, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1787488, Length=235, Percent_Identity=26.3829787234043, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=24.7899159663866, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=25.6916996047431, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=24.4979919678715, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=24.4979919678715, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32240; Mature: 32240

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTRATSKQLMPVYDKPMIYYPLSTLMLAGIKDILIISTPQDLPR
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCHHHH
FKDLLLDGSEFGIRLSYAEQPSPDGLAQAFLIGEDFIGDDSVALILGDNIYHGPGLSKML
HHHHHCCCCCCCEEEEECCCCCCCHHHHEEEECCCCCCCCCEEEEECCCCCCCCCHHHHH
QKTVSKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEKPECPRSNYAVTGLYFYDNDV
HHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKSIKPSARGELEITDVNKAYLDRGNLSVEVMGRGFAWLDTGTHESLLEASQYIETV
HHHHHHCCCCCCCCEEEEECCHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHH
QRMQNVQVANLEEIAYRMGYISREDVLELAQPLKKNEYGQYLLRLIGEV
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTRATSKQLMPVYDKPMIYYPLSTLMLAGIKDILIISTPQDLPR
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCHHHH
FKDLLLDGSEFGIRLSYAEQPSPDGLAQAFLIGEDFIGDDSVALILGDNIYHGPGLSKML
HHHHHCCCCCCCEEEEECCCCCCCHHHHEEEECCCCCCCCCEEEEECCCCCCCCCHHHHH
QKTVSKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEKPECPRSNYAVTGLYFYDNDV
HHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKSIKPSARGELEITDVNKAYLDRGNLSVEVMGRGFAWLDTGTHESLLEASQYIETV
HHHHHHCCCCCCCCEEEEECCHHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHH
QRMQNVQVANLEEIAYRMGYISREDVLELAQPLKKNEYGQYLLRLIGEV
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]