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The map label for this gene is murA-1

Identifier: 116515884

GI number: 116515884

Start: 981327

End: 982586

Strand: Direct

Name: murA-1

Synonym: SPD_0967

Alternate gene names: 116515884

Gene position: 981327-982586 (Clockwise)

Preceding gene: 116516023

Following gene: 116516477

Centisome position: 47.96

GC content: 40.87

Gene sequence:

>1260_bases
ATGAGAAAAATTGTTATCAATGGTGGATTACCACTGCAAGGTGAAATCACTATTAGTGGTGCTAAAAATAGTGTCGTTGC
CTTAATTCCAGCTATTATCTTGGCTGATGATGTGGTGACTTTGGATTGCGTTCCAGATATTTCGGATGTAGCCAGTCTTG
TCGAAATCATGGAATTGATGGGAGCTACTGTTAAGCGTTATGACGATGTATTGGAGATTGACCCAAGAGGTGTTCAAAAT
ATTCCAATGCCTTATGGTAAAATTAACAGTCTTCGTGCATCTTACTATTTTTATGGGAGCCTCTTAGGCCGTTTTGGTGA
AGCGACAGTTGGTCTACCGGGAGGATGTGATCTTGGTCCTCGTCCGATTGACTTACACCTTAAGGCGTTTGAAGCTATGG
GTGCCACTGCTAGCTACGAGGGAGATAACATGAAGTTATCTGCTAAAGATACAGGACTTCATGGTGCAAGTATTTACATG
GATACGGTTAGTGTGGGAGCAACGATTAATACGATGATTGCTGCGGTTAAAGCAAATGGTCGTACTATTATTGAAAATGC
AGCCCGTGAACCTGAGATTATTGATGTAGCTACTCTCTTGAATAATATGGGTGCCCATATCCGTGGGGCAGGAACTAATA
TCATCATTATTGATGGTGTTGAAAGATTACATGGGACACGTCATCAGGTGATTCCAGACCGCATTGAAGCTGGAACATAT
ATATCTTTAGCTGCTGCAGTTGGTAAAGGAATTCGTATAAATAATGTTCTTTACGAACACCTGGAAGGGTTTATTGCTAA
GTTGGAAGAAATGGGAGTGAGAATGACTGTATCTGAAGACAGCATTTTTGTCGAGGAACAGTCTAATTTGAAAGCAATCA
ATATTAAGACAGCTCCTTACCCAGGCTTTGCAACTGATTTGCAACAACCGCTTACCCCTCTTTTACTAAGAGCGAATGGT
CGTGGTACAATTGTCGATACGATTTACGAAAAACGTGTAAATCATGTTTTTGAACTAGCAAAGATGGATGCGGATATTTC
GACAACAAATGGTCATATTTTGTACACGGGTGGACGTGATTTACGTGGGGCCAGTGTTAAAGCGACCGACTTAAGAGCTG
GGGCTGCACTAGTCATTGCTGGGCTTATGGCTGAAGGCAAAACTGAAATTACCAATATCGAGTTTATCTTACGTGGTTAT
TCTGATATTATCGAAAAATTACGTAATTTAGGAGCGGATATTAGACTTGTTGAGGATTAA

Upstream 100 bases:

>100_bases
ATCCAATAAAATTGAAAAGGATGGAAAAAAGGATAAATTTATGATATACTTTATTTTGAAGACCTTATTAGAAATCTTGA
AAGAGTATTGAAAACTTAGA

Downstream 100 bases:

>100_bases
ACCGTAGAGGTGTTTATGAATATTTGGACCAAATTAGCAATGTTTTCTTTTTTTGAAACGGATCGCTTGTATTTGCGTCC
TTTCTTTTTTAGTGATAGTC

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 2; UDP-N-acetylglucosamine enolpyruvyl transferase 2; EPT 2

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQN
IPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM
DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTY
ISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANG
RGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGY
SDIIEKLRNLGADIRLVED

Sequences:

>Translated_419_residues
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQN
IPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM
DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTY
ISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANG
RGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGY
SDIIEKLRNLGADIRLVED
>Mature_419_residues
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQN
IPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM
DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTY
ISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANG
RGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGASVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGY
SDIIEKLRNLGADIRLVED

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=420, Percent_Identity=45.4761904761905, Blast_Score=333, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA2_STRPN (Q97QW6)

Other databases:

- EMBL:   AE005672
- PIR:   A95125
- RefSeq:   NP_345554.1
- ProteinModelPortal:   Q97QW6
- SMR:   Q97QW6
- EnsemblBacteria:   EBSTRT00000026560
- GeneID:   931595
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_1081
- TIGR:   SP_1081
- GeneTree:   EBGT00050000028044
- HOGENOM:   HBG482701
- OMA:   MKKIVIN
- ProtClustDB:   PRK12830
- BioCyc:   SPNE170187-1:SP_1081-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45026; Mature: 45026

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELM
CCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH
GATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGP
HHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
RPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYMDTVSVGATINTMIAAVKANG
CCEEEEEEEHHHCCCCEEECCCCEEEEECCCCCCCCEEEEEEEECCCCHHHEEEEEECCC
RTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTY
CEEEHHCCCCCCEEHHHHHHHHCCCEEEECCCEEEEECCHHHHCCCCCCCCCHHHCCCCE
ISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPY
EEEHHHHCCCCEEHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCEEEEEEECCCC
PGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRD
CCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
LRGASVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGYSDIIEKLRNLGADIRLVED
CCCCEEEEHHCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELM
CCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH
GATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGP
HHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
RPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYMDTVSVGATINTMIAAVKANG
CCEEEEEEEHHHCCCCEEECCCCEEEEECCCCCCCCEEEEEEEECCCCHHHEEEEEECCC
RTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTY
CEEEHHCCCCCCEEHHHHHHHHCCCEEEECCCEEEEECCHHHHCCCCCCCCCHHHCCCCE
ISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPY
EEEHHHHCCCCEEHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCEEEEEEECCCC
PGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRD
CCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
LRGASVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGYSDIIEKLRNLGADIRLVED
CCCCEEEEHHCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916