Click here to switch to the map view.

The map label for this gene is vraS [H]

Identifier: 116515827

GI number: 116515827

Start: 355197

End: 356192

Strand: Direct

Name: vraS [H]

Synonym: SPD_0351

Alternate gene names: 116515827

Gene position: 355197-356192 (Clockwise)

Preceding gene: 116516981

Following gene: 116517140

Centisome position: 17.36

GC content: 43.17

Gene sequence:

>996_bases
ATGAAAAAACAAGCCTATGTCATTATTGCTCTCACCTCCTTCCTGTTTGTCTTTTTTTTCTCCCACAGCTTGCTGGAAAT
ACTTGATTTTGACTGGTCTATCTTTTTGCACGATGTCGAAAAAACAGAAAAATTTGTCTTTTTATTGTTGGTTTTCAGCA
TGTCCATAACCTGTCTCTTAGCCCTGTTTTGGCGAGGGATCGAAGAGCTTTCTCTAAGAAAAATGCAGGCTAATCTCAAG
CGTTTATTGGCAGGGCAAGAAGTAGTTCAGGTTGTAGATCCAGATTTGGATGCCAGTTTCAAGTCCTTATCAGGTAAACT
TAACCTTTTGACAGAGGCTCTTCAAAAAGCAGAAAATCAGAGTCTTGCTCAGGAAGAGGAAATCATCGAGAAGGAACGGA
AGCGAATTGCTCGGGATTTGCACGATACAGTCAGTCAGGAGTTGTTTGCGGCCCACATGATTTTATCGGGTATCAGTCAG
CAGGCTTTGAAATTGGATAGAGAAAAGATGCAGACCCAGTTGCAGAGTGTCACAGCTATTTTAGAAACAGCCCAGAAGGA
TTTGCGGGTTTTGCTCTTGCATTTGCGACCAGTTGAACTGGAGCAGAAGAGCTTGATAGAAGGGATTCAAATTCTCTTAA
AAGAGCTTGAGGACAAGAGTGATCTTAGGGTTAGTCTCAAGCAGAATATGACGAAATTGCCTAAGAAAATCGAGGAGCAT
ATTTTCCGTATCCTGCAAGAGTTGATTAGCAATACGCTCCGCCATGCCCAGGCATCTTGCCTAGATGTCTACCTCTATCA
GACAGATGTTGAATTGCAACTGAAGGTGGTGGACAATGGGATTGGTTTCCAGTTAGGGAGCTTAGACGACTTGAGTTATG
GACTGCGAAATATCAAGGAGCGGGTTGAAGATATGGCAGGGACGGTTCAGTTATTAACAGCTCCCAAGCAAGGGCTGGCA
GTTGATATCCGTATTCCCCTGTTAGATAAGGAATGA

Upstream 100 bases:

>100_bases
ATGAACACTATCATCAAGAAACAAAAGACTATCTCAAGAGTAACAAGAGTGTCAAGATTTTCTTGACCACTATGATTGGT
GATGTGGAGGTGGTTAGAGG

Downstream 100 bases:

>100_bases
TAAAGGAGTAAAGATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCC
AAGACGATGTAGAAGTTGTG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEKFVFLLLVFSMSITCLLALFWRGIEELSLRKMQANLK
RLLAGQEVVQVVDPDLDASFKSLSGKLNLLTEALQKAENQSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELEDKSDLRVSLKQNMTKLPKKIEEH
IFRILQELISNTLRHAQASCLDVYLYQTDVELQLKVVDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLA
VDIRIPLLDKE

Sequences:

>Translated_331_residues
MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEKFVFLLLVFSMSITCLLALFWRGIEELSLRKMQANLK
RLLAGQEVVQVVDPDLDASFKSLSGKLNLLTEALQKAENQSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELEDKSDLRVSLKQNMTKLPKKIEEH
IFRILQELISNTLRHAQASCLDVYLYQTDVELQLKVVDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLA
VDIRIPLLDKE
>Mature_331_residues
MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEKFVFLLLVFSMSITCLLALFWRGIEELSLRKMQANLK
RLLAGQEVVQVVDPDLDASFKSLSGKLNLLTEALQKAENQSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
QALKLDREKMQTQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELEDKSDLRVSLKQNMTKLPKKIEEH
IFRILQELISNTLRHAQASCLDVYLYQTDVELQLKVVDNGIGFQLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLA
VDIRIPLLDKE

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates vraR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788812, Length=196, Percent_Identity=27.0408163265306, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082311, Length=229, Percent_Identity=30.5676855895196, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR017202 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37913; Mature: 37913

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHEECCCCCCEEEEEECCCCCC
>Mature Secondary Structure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HHHHHHHHHHHEECCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA