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The map label for this gene is zwf [H]

Identifier: 116515777

GI number: 116515777

Start: 1130243

End: 1131730

Strand: Direct

Name: zwf [H]

Synonym: SPD_1100

Alternate gene names: 116515777

Gene position: 1130243-1131730 (Clockwise)

Preceding gene: 116516532

Following gene: 116515939

Centisome position: 55.24

GC content: 41.6

Gene sequence:

>1488_bases
ATGTCATCTAAGGTTATTGTTACAATTTTCGGTGCGAGTGGAGACCTGGCTAAACGCAAGCTCTACCCTTCCCTTTTTAG
ACTATATAAATCCGGCAATCTTTCCAAGCACTTTGCCGTTATTGGAACTGCCCGTAGACCTTGGAGTAAGGAATATTTTG
AATCTGTAGTTGTCGAGTCCATCCTTGATTTGGCAGATAGTACCGAGCAAGCCCAAGAATTTGCTAGCCACTTCTACTAT
CAAAGCCATGATGTCAATGATTCGGAACATTATATTGCTTTGCGTCAATTACAAGCTGAGCTTAATGAAAAATACCAAGC
TGAACACAATAAGCTCTTCTTCTTGTCTATGGCACCTCAGTTCTTTGGAACCATTGCCAAACACCTCAAATCTGAAAACA
TTGTCGATGGCAAAGGTTTTGAGCGCTTGATCGTTGAAAAACCATTTGGTACAGATTACGCAACTGCAAACAAGTTGAAT
GACGAACTCCTAGCAACATTTGACGAAGAACAAATTTTCCGTATCGACCATTATCTTGGTAAGGAAATGATCCAAAGCAT
CTTTGCAGTTCGCTTTGCAAACTTGATTTTTGAAAACGTTTGGAACAAGGATTTTATCGACAATGTTCAAATTACCTTTG
CGGAGCGCTTGGGTGTAGAAGAACGTGGTGGCTACTATGACCAATCCGGTGCCCTCCGTGACATGGTCCAAAACCACACT
CTACAACTTCTTTCGCTCCTCGCCATGGACAAACCAGCAAGCTTCACAAAAGACGAGATTCGTGCTGAAAAGATTAAGGT
CTTTAAAAACCTCTATCATCCAACTGATGAAGAACTCAAAGAACACTTTATCCGTGGGCAATACCGCTCTGGTAAGATTG
ATGGCATGAAATACATCTCTTATCGTAGCGAGCCAAATGTGAATCCAGAATCAACAACTGAAACCTTTACATCTGGTGCC
TTCTTTGTAGACAGCGATCGATTCCGTGGTGTTCCTTTCTTTTTCCGTACAGGTAAACGACTGACTGAAAAAGGAACTCA
TGTCAACATCGTCTTTAAACAAATGGATTCTATCTTTGGAGAACCACTTGCTCCAAATATTTTGACCATCTATATTCAAC
CAACAGAAGGCTTCTCTCTTAGCCTAAATGGGAAGCAAGTAGGAGAAGAATTTAACTTGGCTCCTAACTCACTTGATTAC
CGTACAGATGCGACTGCAACTGGTGCTTCTCCAGAACCATACGAAAAATTGATTTATGATGTCCTAAATAACAACTCAAC
TAACTTTAGCCACTGGGATGAAGTTTGTGCGTCATGGAAGTTGATTGACCGTATTGAAAAGCTCTGGGCTGAAAATGGTG
CCCCACTTCATGACTATAAAGCTGGAAGCATGGGACCTCAAGCCAGCTTTGACCTACTTGAAAAATTCGGTGCCAAATGG
ACTTGGCAACCAGATATCACCTATCGTCAAGATGGTCGCTTAGAATAA

Upstream 100 bases:

>100_bases
TTTTTGATTTTTCGGAAAATTATGTTAGAATTAAGTTTATGAAATGAGGTTTCCTCATACCTAGCAAGACTAGGAATAAA
AATAGAAATTAGGTAGCTAG

Downstream 100 bases:

>100_bases
AAAAATTTCCTGCAAGTTTATGCCTTGCAGGATTTTTGCTTCTGATTAGATTAAACCTTCCAAGAGACCTTTCATAAAGT
TTTCTGAGTTAAACTCTCCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVESILDLADSTEQAQEFASHFYY
QSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATANKLN
DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGA
FFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDY
RTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVCASWKLIDRIEKLWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
TWQPDITYRQDGRLE

Sequences:

>Translated_495_residues
MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVESILDLADSTEQAQEFASHFYY
QSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATANKLN
DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGA
FFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDY
RTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVCASWKLIDRIEKLWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
TWQPDITYRQDGRLE
>Mature_494_residues
SSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVESILDLADSTEQAQEFASHFYYQ
SHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATANKLND
ELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHTL
QLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGAF
FVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDYR
TDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVCASWKLIDRIEKLWAENGAPLHDYKAGSMGPQASFDLLEKFGAKWT
WQPDITYRQDGRLE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=34.8360655737705, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=34.8360655737705, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI52145310, Length=369, Percent_Identity=28.7262872628726, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1788158, Length=485, Percent_Identity=38.3505154639175, Blast_Score=315, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17538218, Length=488, Percent_Identity=34.4262295081967, Blast_Score=265, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=35.2459016393443, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24643350, Length=486, Percent_Identity=33.9506172839506, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24643352, Length=486, Percent_Identity=33.9506172839506, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI221513548, Length=483, Percent_Identity=27.9503105590062, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56817; Mature: 56686

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVES
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
ILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQ
HHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHH
FFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATANKLNDELLATFDEEQIFRIDHYLG
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCHHHHHHCCHHHHHHHHHHHH
KEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHCCCCCCCCCHHHHHHHHHH
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEE
YRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFG
ECCCCCCCCCCCHHHHCCCEEEEECCCCCCCCHHHHCCCHHHHCCCEEEEHHHHHHHHHC
EPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDYRTDATATGASPEPYEKLIYD
CCCCCCEEEEEEECCCCCEEEECHHHHCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VLNNNSTNFSHWDEVCASWKLIDRIEKLWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCE
TWQPDITYRQDGRLE
EECCCCCCCCCCCCC
>Mature Secondary Structure 
SSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVES
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
ILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQ
HHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHH
FFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATANKLNDELLATFDEEQIFRIDHYLG
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCHHHHHHCCHHHHHHHHHHHH
KEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHCCCCCCCCCHHHHHHHHHH
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEE
YRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFG
ECCCCCCCCCCCHHHHCCCEEEEECCCCCCCCHHHHCCCHHHHCCCEEEEHHHHHHHHHC
EPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDYRTDATATGASPEPYEKLIYD
CCCCCCEEEEEEECCCCCEEEECHHHHCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VLNNNSTNFSHWDEVCASWKLIDRIEKLWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCE
TWQPDITYRQDGRLE
EECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916; 9466257; 9533725 [H]