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The map label for this gene is pyrG [H]

Identifier: 116515581

GI number: 116515581

Start: 444553

End: 446160

Strand: Direct

Name: pyrG [H]

Synonym: SPD_0442

Alternate gene names: 116515581

Gene position: 444553-446160 (Clockwise)

Preceding gene: 116516666

Following gene: 116516927

Centisome position: 21.73

GC content: 44.22

Gene sequence:

>1608_bases
ATGTCTACGAAATATATTTTTGTAACTGGTGGTGTGGTATCGTCTATTGGGAAAGGGATTGTGGCAGCGAGTCTAGGCCG
TCTCTTGAAAAATCGTGGTCTCAAAGTAACCATTCAAAAGTTTGACCCTTATATCAATATTGATCCGGGAACCATGAGTC
CTTACCAGCACGGGGAAGTTTTTGTGACAGATGACGGAGCTGAGACAGATTTGGACTTGGGTCACTATGAACGTTTCATC
GATATCAATCTCAACAAATATTCCAACGTGACAACTGGGAAAATTTACAGTGAAGTTCTTCGTAAAGAACGCCGTGGAGA
ATACCTTGGGGCAACTGTTCAAGTCATTCCTCATATCACAGATGCTTTGAAAGAAAAAATCAAGCGTGCCGCTCTAACGA
CCGACTCTGATGTCATTATCACAGAGGTTGGTGGAACAGTAGGAGATATCGAGTCCTTGCCATTCCTAGAGGCTCTTCGT
CAGATGAAGGCAGATGTGGGTGCGGATAATGTCATGTATATCCATACAACCTTGCTTCCTTACCTCAAGGCTGCTGGTGA
AATGAAAACCAAACCAACCCAACACTCTGTCAAAGAATTGCGTGGCTTGGGAATCCAACCAAATATGTTGGTTATTCGTA
CAGAAGAGCCAGCTGGTCAAGGAATTAAAAATAAACTGGCCCAGTTCTGTGATGTGGCACCAGAAGCCGTTATCGAATCG
TTGGATGTTGAACACCTTTACCAAATTCCACTGAACTTGCAGGCACAAGGGATGGACCAAATTGTTTGTGATCATTTGAA
ATTAGACGCACCAGCAGCGGATATGACAGAATGGTCAGCCATGGTGGACAAGGTCATGAACCTCAAGAAACAAGTTAAGA
TTTCCCTTGTTGGTAAGTATGTGGAGTTGCAAGATGCCTATATCTCAGTGGTCGAAGCCTTGAAACACTCTGGCTATGTC
AATGATGTAGAAGTTAAAATCAATTGGGTCAATGCCAATGATGTGACAGCAGAGAATGTAGCAGAACTCTTGTCTGATGC
GGACGGGATCATCGTACCAGGTGGTTTTGGTCAACGTGGTACAGAAGGGAAAATCCAAGCCATCCGCTATGCGCGTGAAA
ATGATGTTCCAATGTTGGGAGTCTGCTTGGGAATGCAGTTGACATGTATCGAGTTTGCTCGTCACGTTTTAGGTCTTGAA
GGTGCCAATTCTGCAGAGCTTGCACCAGAAACAAAATACCCTATCATTGATATCATGCGTGATCAGATTGATATTGAGGA
TATGGGTGGAACCCTTCGTTTGGGACTTTATCCGTCTAAGTTGAAACGTGGCTCTAAGGCTGCTGCTGCTTATCACAATC
AAGAAGTGGTGCAACGCCGTCACCGTCACCGTTATGAGTTTAATAATGCCTTCCGTGAGCAGTTTGAGGCAGCAGGTTTT
GTCTTTTCAGGAGTTTCTCCAGACAATCGTTTGGTAGAAATCGTGGAAATTCCTGAAAATAAATTCTTTGTAGCTTGTCA
GTATCACCCTGAACTGTCAAGCCGTCCAAACCGACCAGAAGAACTCTACACTGCCTTTGTTACTGCAGCGGTTGAGAACA
GCAATTAG

Upstream 100 bases:

>100_bases
ATCTGGTGCAGTCGTCCCAGATTATTCTTATTAGTAGGGTCTTGTTTTCTATATCCCCTCGTAGTTAACAAGACCTTGAG
CATTTTAGAAAGAGGAATCT

Downstream 100 bases:

>100_bases
CAAAATCAGAACCTTTGAGAAAAATCTCAGAGGTTTTTTGCATACGATGATATTGCAGTATATCTGAGGTAGGAGTCCTC
TGTATGTACCTGCTACCGTT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DINLNKYSNVTTGKIYSEVLRKERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALR
QMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKLAQFCDVAPEAVIES
LDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMTEWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYV
NDVEVKINWVNANDVTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEFARHVLGLE
GANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAAYHNQEVVQRRHRHRYEFNNAFREQFEAAGF
VFSGVSPDNRLVEIVEIPENKFFVACQYHPELSSRPNRPEELYTAFVTAAVENSN

Sequences:

>Translated_535_residues
MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFI
DINLNKYSNVTTGKIYSEVLRKERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALR
QMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKLAQFCDVAPEAVIES
LDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMTEWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYV
NDVEVKINWVNANDVTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEFARHVLGLE
GANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAAYHNQEVVQRRHRHRYEFNNAFREQFEAAGF
VFSGVSPDNRLVEIVEIPENKFFVACQYHPELSSRPNRPEELYTAFVTAAVENSN
>Mature_534_residues
STKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSEVLRKERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALRQ
MKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKLAQFCDVAPEAVIESL
DVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMTEWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYVN
DVEVKINWVNANDVTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEFARHVLGLEG
ANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAAYHNQEVVQRRHRHRYEFNNAFREQFEAAGFV
FSGVSPDNRLVEIVEIPENKFFVACQYHPELSSRPNRPEELYTAFVTAAVENSN

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=548, Percent_Identity=47.0802919708029, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI28559085, Length=554, Percent_Identity=46.028880866426, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI28559083, Length=554, Percent_Identity=46.028880866426, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI221316689, Length=554, Percent_Identity=46.028880866426, Blast_Score=490, Evalue=1e-138,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=52.7675276752767, Blast_Score=577, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=38.3471074380165, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319432, Length=562, Percent_Identity=44.4839857651246, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322563, Length=562, Percent_Identity=44.8398576512456, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24664469, Length=552, Percent_Identity=44.7463768115942, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=497, Percent_Identity=42.2535211267606, Blast_Score=408, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59257; Mature: 59126

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEV
CCCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERRGEYLGATVQVIPHIT
EEECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGADNVMYIHTTLLP
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHH
YLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKLAQFCDVAPEAVIES
HHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHH
LDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMTEWSAMVDKVMNLKKQVKISLVGKY
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHH
VELQDAYISVVEALKHSGYVNDVEVKINWVNANDVTAENVAELLSDADGIIVPGGFGQRG
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCC
TEGKIQAIRYARENDVPMLGVCLGMQLTCIEFARHVLGLEGANSAELAPETKYPIIDIMR
CCCHHHHEEECCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DQIDIEDMGGTLRLGLYPSKLKRGSKAAAAYHNQEVVQRRHRHRYEFNNAFREQFEAAGF
HHCCHHHCCCEEEECCCHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
VFSGVSPDNRLVEIVEIPENKFFVACQYHPELSSRPNRPEELYTAFVTAAVENSN
EEECCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHEECCCC
>Mature Secondary Structure 
STKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEV
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERRGEYLGATVQVIPHIT
EEECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGADNVMYIHTTLLP
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHH
YLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKLAQFCDVAPEAVIES
HHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHH
LDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMTEWSAMVDKVMNLKKQVKISLVGKY
CCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHHHH
VELQDAYISVVEALKHSGYVNDVEVKINWVNANDVTAENVAELLSDADGIIVPGGFGQRG
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCC
TEGKIQAIRYARENDVPMLGVCLGMQLTCIEFARHVLGLEGANSAELAPETKYPIIDIMR
CCCHHHHEEECCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DQIDIEDMGGTLRLGLYPSKLKRGSKAAAAYHNQEVVQRRHRHRYEFNNAFREQFEAAGF
HHCCHHHCCCEEEECCCHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCE
VFSGVSPDNRLVEIVEIPENKFFVACQYHPELSSRPNRPEELYTAFVTAAVENSN
EEECCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA