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The map label for this gene is galE-2 [H]

Identifier: 116515568

GI number: 116515568

Start: 1626582

End: 1627562

Strand: Reverse

Name: galE-2 [H]

Synonym: SPD_1612

Alternate gene names: 116515568

Gene position: 1627562-1626582 (Counterclockwise)

Preceding gene: 116516923

Following gene: 116517152

Centisome position: 79.54

GC content: 37.1

Gene sequence:

>981_bases
ATGGCAATATTGGTAACAGGCGGAGCTGGTTATATTGGTAGCCATACCGTAGTAGAATTACTAAATTTAGGAAAGGAAGT
CATCATTGTCGACAACCTTTCGAACTCTAGCATCTTGGTGCTAGACCGTATTGAAGCAATTACAGGAATACGTCCCGTGT
TTTACGAATTAGATGTTTGTGATAAACCAGCATTGAGAAAGGTATTTGAACAAGAATCGATTGATGCTGCAATTCATTTT
GCAGGTTATAAAGCTGTCGGAGAATCCGTGCAAAAGCCTGTGATGTACTACAAAAATAATATTATGAGTACATTGGCACT
TGTTGAAGTGATGTCAGAATTTAATGTTAAAAAGATTGTCTTTTCTTCAAGTGCGACTGTATATGGAATTAACAATCAGT
CACCTCTAATTGAGACTATGCAAACAAGTGCGACAAATCCTTATGGGTATACGAAAGTGATGCTTGAGCAAATTTTAAAA
GATGTTCATGTGGCAGATTCAGAATGGAGTATTGCGTTGCTTCGTTATTTCAATCCAATTGGTGCTCATGAGTCTGGTTT
GATTGGGGAAGATCCCTCAGGAATTCCTAACAACTTGATGCCCTATATTGCACAAGTAGCGGTAGGTAAGCTGTCAGAAC
TAAGTGTGTTCGGAAATGATTATGATACGCTTGACGGTACTGGTGTGCGCGATTATATCCATGTAGTAGATTTAGCAATA
GGACATATAAAAGCTTTAGAAAAAGTATCTGAAAAAACAGATGTTTATATCTATAACCTAGGCTCGGGAGAAGGCACTAG
TGTATTACAACTTGTAAATACATTTGAAAGTGTTAATAAGATCCCTATTCCTTATAAAATAGTTCCAAGACGTTCAGGAG
ACGTTGCAACTTGTTATGCAAATGCAGACAAAGCATATAAGGAATTAAATTGGAGGACAACAAAATCGATTGAAGACATG
TGTAGAGATACATGGAATTAG

Upstream 100 bases:

>100_bases
AGTTCTGGAAGATGCAGGAGTTTATAAGAATACACCGTCTGGGCATGAAGCGTTTATGAGATTTGTTAAGTCGGTTGGAA
TTAATTAGGAGGAAACAAAA

Downstream 100 bases:

>100_bases
CAATCAAAAAATCCCAATGGCTATAATTGATGATACTGTCTATATGAGTGCTGTATTTTGGAAAAATTACTTAACCTTTT
AATGAAATGCATATTTAATG

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAILVTGGAGYIGSHTVVELLNLGKEVIIVDNLSNSSILVLDRIEAITGIRPVFYELDVCDKPALRKVFEQESIDAAIHF
AGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILK
DVHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDM
CRDTWN

Sequences:

>Translated_326_residues
MAILVTGGAGYIGSHTVVELLNLGKEVIIVDNLSNSSILVLDRIEAITGIRPVFYELDVCDKPALRKVFEQESIDAAIHF
AGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILK
DVHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDM
CRDTWN
>Mature_325_residues
AILVTGGAGYIGSHTVVELLNLGKEVIIVDNLSNSSILVLDRIEAITGIRPVFYELDVCDKPALRKVFEQESIDAAIHFA
GYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILKD
VHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAIG
HIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDMC
RDTWN

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=331, Percent_Identity=54.6827794561934, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI56118217, Length=331, Percent_Identity=54.6827794561934, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI189083684, Length=331, Percent_Identity=54.6827794561934, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI7657641, Length=280, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786974, Length=327, Percent_Identity=55.9633027522936, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI48994969, Length=347, Percent_Identity=25.9365994236311, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788353, Length=360, Percent_Identity=26.3888888888889, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=336, Percent_Identity=52.6785714285714, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71982038, Length=338, Percent_Identity=52.3668639053254, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17568069, Length=335, Percent_Identity=26.2686567164179, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115532424, Length=348, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=332, Percent_Identity=53.0120481927711, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19923002, Length=332, Percent_Identity=53.9156626506024, Blast_Score=356, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 35932; Mature: 35801

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVTGGAGYIGSHTVVELLNLGKEVIIVDNLSNSSILVLDRIEAITGIRPVFYELDVC
CEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHHCCCCEEEEECCC
DKPALRKVFEQESIDAAIHFAGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIV
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
FSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILKDVHVADSEWSIALLRYFNPI
EECCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
GAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHH
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYA
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEE
NADKAYKELNWRTTKSIEDMCRDTWN
CHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AILVTGGAGYIGSHTVVELLNLGKEVIIVDNLSNSSILVLDRIEAITGIRPVFYELDVC
EEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHHCCCCEEEEECCC
DKPALRKVFEQESIDAAIHFAGYKAVGESVQKPVMYYKNNIMSTLALVEVMSEFNVKKIV
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
FSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILKDVHVADSEWSIALLRYFNPI
EECCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
GAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFGNDYDTLDGTGVRDYIHVVDLAI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCHHHHHHHHHHHH
GHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFESVNKIPIPYKIVPRRSGDVATCYA
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEE
NADKAYKELNWRTTKSIEDMCRDTWN
CHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]