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The map label for this gene is lacR1 [H]

Identifier: 116515565

GI number: 116515565

Start: 781917

End: 782657

Strand: Direct

Name: lacR1 [H]

Synonym: SPD_0771

Alternate gene names: 116515565

Gene position: 781917-782657 (Clockwise)

Preceding gene: 116516125

Following gene: 116516872

Centisome position: 38.21

GC content: 42.78

Gene sequence:

>741_bases
GTGTTAAAAACAGAGCGGAAGCAACTGATTTTAGAGGAGTTAAATCAACATCATGTAGTTTCTCTAGAAAAATTAGTTAG
TTTGCTAGAAACGTCAGAATCAACGGTTCGAAGAGACTTGGATGAGTTGGAAGCGGAAAACAAGCTTCGTCGTGTGCATG
GTGGAGCAGAACTCCCCCACTCCTTACAGGAAGAAGAAACCATTCAAGAAAAATCGGTCAAAAACCTTCAAGAAAAGAAG
TTGCTGGCTCAGAAAGCAGCCTCTCTCATTAAAGAAAAAGATGTCATCTTTATCGATGCTGGAACAACAACTGCTTTTTT
GATTCATGAATTGGTCAATAAGAATGTTACAGTTGTGACCAACTCCATTCACCATGCCGCTCAGTTGGTTGAAAAGCAGA
TTCCAACTGTCATGGTTGGAGGAAACGTCAAGACGGCGACAGATGCTAGTATCGGGGGCGTTGCTCTTAACCAGATTAAC
CAATTGCACTTTGACCGTGCCTTTATCGGAATGAATGGTGTTGACGATGGCTATTATACGACTCCTGATATGGAGGAGGG
AGCTGTGAAAAGAGCTATTTTGGAGAATGCCAAGCAGACCTACGTCTTGGTGGATTCGTCAAAAATTGGACAAACTTGCT
TTGCCAAGGTAGCACCACTCAAACGCGCTATCGTTATCACTAGTCAAGGGCATGAGCTCTTGCAGGTTATTAAGGAGAAA
ACGGAGGTAATAGAAGTATGA

Upstream 100 bases:

>100_bases
AGAAAAATGATAGATTTTGAAAGAAAATGATAAAAAATGCTTGACTTCAAAAGAAAGTATGATAGAATGAATAGTGTAAA
CGATAACAGGAGGTGATTCG

Downstream 100 bases:

>100_bases
TTTATACAGTCACACTCAATCCATCCATTGACTATATCGTTCGTTTGGACCAAGTCAAAGTTGGTAGTGTAAATCGTATG
GACAGTGATGATAAGTTTGC

Product: lactose phosphotransferase system repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELEAENKLRRVHGGAELPHSLQEEETIQEKSVKNLQEKK
LLAQKAASLIKEKDVIFIDAGTTTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
QLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVAPLKRAIVITSQGHELLQVIKEK
TEVIEV

Sequences:

>Translated_246_residues
MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELEAENKLRRVHGGAELPHSLQEEETIQEKSVKNLQEKK
LLAQKAASLIKEKDVIFIDAGTTTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
QLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVAPLKRAIVITSQGHELLQVIKEK
TEVIEV
>Mature_246_residues
MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELEAENKLRRVHGGAELPHSLQEEETIQEKSVKNLQEKK
LLAQKAASLIKEKDVIFIDAGTTTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
QLHFDRAFIGMNGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVAPLKRAIVITSQGHELLQVIKEK
TEVIEV

Specific function: Repressor Of The Glycerol-3-Phosphate Regulon. [C]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=224, Percent_Identity=33.9285714285714, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI226510968, Length=223, Percent_Identity=31.390134529148, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787540, Length=220, Percent_Identity=33.6363636363636, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1789059, Length=214, Percent_Identity=30.8411214953271, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789519, Length=234, Percent_Identity=29.4871794871795, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789170, Length=223, Percent_Identity=26.9058295964126, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790635, Length=242, Percent_Identity=28.099173553719, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1788069, Length=245, Percent_Identity=26.9387755102041, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790753, Length=212, Percent_Identity=26.8867924528302, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082344, Length=192, Percent_Identity=28.125, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787063, Length=231, Percent_Identity=29.8701298701299, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 27278; Mature: 27278

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELEAENKLRRVHGGAELPH
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGTTTAFLIHELVNKNVTVVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCEEEEE
NSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQINQLHFDRAFIGMNGVDDGYYT
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVAPLKRAIVITSQGHELLQVIKEK
CCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHH
TEVIEV
HHHHCC
>Mature Secondary Structure
MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELEAENKLRRVHGGAELPH
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGTTTAFLIHELVNKNVTVVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCEEEEE
NSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQINQLHFDRAFIGMNGVDDGYYT
HHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVAPLKRAIVITSQGHELLQVIKEK
CCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHH
TEVIEV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]