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The map label for this gene is obgE [H]

Identifier: 116515321

GI number: 116515321

Start: 977227

End: 978537

Strand: Direct

Name: obgE [H]

Synonym: SPD_0964

Alternate gene names: 116515321

Gene position: 977227-978537 (Clockwise)

Preceding gene: 116516165

Following gene: 116516023

Centisome position: 47.76

GC content: 43.63

Gene sequence:

>1311_bases
ATGAGTATGTTTTTAGATACAGCTAAGATTAAGGTCAAGGCTGGTAATGGTGGCGATGGTATGGTTGCCTTTCGTCGTGA
AAAATATGTCCCTAATGGAGGCCCTTGGGGTGGTGATGGTGGTCGTGGAGGCAATGTGGTCTTCGTTGTAGACGAAGGAC
TACGTACCTTGATGGATTTCCGCTACAATCGTCATTTCAAGGCTGATTCTGGTGAAAAAGGGATGACCAAAGGGATGCAT
GGTCGTGGTGCTGAGGACCTTAGAGTTCGAGTACCACAAGGTACGACTGTTCGTGATGCGGAGACTGGCAAGGTTTTAAC
AGATTTGATTGAACATGGGCAAGAATTTATCGTTGCCCACGGTGGTCGTGGTGGACGTGGAAATATTCGTTTCGCGACAC
CAAAAAATCCTGCACCGGAAATCTCTGAAAATGGAGAACCAGGTCAGGAACGTGAGTTACAATTGGAACTAAAAATCTTG
GCAGATGTCGGTTTAGTAGGATTCCCATCTGTAGGGAAGTCAACACTTTTAAGTGTTATTACCTCAGCTAAGCCTAAAAT
TGGTGCCTACCACTTTACCACTATTGTACCAAATTTAGGTATGGTTCGCACCCAATCAGGTGAATCCTTTGCAGTAGCCG
ACTTGCCAGGTTTGATTGAAGGGGCTAGTCAAGGTGTTGGTTTGGGAACTCAGTTCCTCCGTCACATCGAGCGTACACGT
GTTATCCTTCACATCATTGATATGTCAGCTAGCGAAGGCCGTGATCCATATGAGGATTACCTAGCTATCAATAAAGAGCT
GGAGTCTTACAATCTTCGCCTCATGGAGCGTCCACAGATTATTGTAACTAATAAGATGGACATGCCTGAGAGTCAGGAAA
ATCTTGAAGAATTTAAGAAAAAATTGGCTGAAAATTATGATGAATTTGAAGAGTTACCAGCTATCTTCCCAATTTCTGGA
TTGACCAAGCAAGGTCTGGCAACACTTTTAGATGCTACAGCTGAATTGTTAGACAAGACACCAGAATTTTTGCTCTACGA
CGAGTCCGATATGGAAGAAGAAGTTTACTATGGATTTGACGAAGAAGAAAAAGCCTTTGAAATTAGTCGTGATGACGATG
CGACATGGGTACTTTCTGGTGAAAAACTCATGAAACTCTTTAATATGACCAACTTTGATCGTGATGAATCTGTCATGAAA
TTTGCCCGTCAGCTTCGTGGTATGGGGGTTGATGAAGCCCTTCGTGCGCGTGGAGCTAAAGATGGGGATTTGGTCCGCAT
TGGTAAATTTGAGTTTGAATTTGTAGACTAG

Upstream 100 bases:

>100_bases
TTTTGCAACTGCAATTGGTGCCCTCAGTAATCTATAAAATAGATTCAAGAAAATTTAGTGACTGGGATTTCCCAGCCCTT
TTTTAAAGTGAGAAGAAATA

Downstream 100 bases:

>100_bases
GAGACTGGTATGGGAGATAAACCGATATCTTTCCGAGATGCGGATGGTAATTTTGTTTCCGCCGCAGACGTTTGGAATGA
AAAGAAATTGGAAGAACTAT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGGNVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMH
GRGAEDLRVRVPQGTTVRDAETGKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGLIEGASQGVGLGTQFLRHIERTR
VILHIIDMSASEGRDPYEDYLAINKELESYNLRLMERPQIIVTNKMDMPESQENLEEFKKKLAENYDEFEELPAIFPISG
LTKQGLATLLDATAELLDKTPEFLLYDESDMEEEVYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNFDRDESVMK
FARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD

Sequences:

>Translated_436_residues
MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGGNVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMH
GRGAEDLRVRVPQGTTVRDAETGKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGLIEGASQGVGLGTQFLRHIERTR
VILHIIDMSASEGRDPYEDYLAINKELESYNLRLMERPQIIVTNKMDMPESQENLEEFKKKLAENYDEFEELPAIFPISG
LTKQGLATLLDATAELLDKTPEFLLYDESDMEEEVYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNFDRDESVMK
FARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD
>Mature_435_residues
SMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGGNVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHG
RGAEDLRVRVPQGTTVRDAETGKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKILA
DVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGLIEGASQGVGLGTQFLRHIERTRV
ILHIIDMSASEGRDPYEDYLAINKELESYNLRLMERPQIIVTNKMDMPESQENLEEFKKKLAENYDEFEELPAIFPISGL
TKQGLATLLDATAELLDKTPEFLLYDESDMEEEVYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNFDRDESVMKF
ARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=339, Percent_Identity=41.5929203539823, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI111955139, Length=357, Percent_Identity=35.2941176470588, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI111955063, Length=189, Percent_Identity=37.5661375661376, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4758796, Length=153, Percent_Identity=36.6013071895425, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4557537, Length=121, Percent_Identity=39.6694214876033, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789574, Length=358, Percent_Identity=44.4134078212291, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=34.7826086956522, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17508313, Length=336, Percent_Identity=39.5833333333333, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=319, Percent_Identity=29.7805642633229, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=39.8305084745763, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17555344, Length=153, Percent_Identity=34.640522875817, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=31.6546762589928, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=196, Percent_Identity=38.7755102040816, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6321612, Length=126, Percent_Identity=39.6825396825397, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=38.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129375, Length=299, Percent_Identity=42.1404682274247, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24585318, Length=373, Percent_Identity=36.7292225201072, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI21356473, Length=126, Percent_Identity=38.0952380952381, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17981711, Length=153, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 48422; Mature: 48290

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGGNVVFVVDEGLRTLMDF
CCCEEEEEEEEEEECCCCCCEEEEEHHCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHH
RYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAETGKVLTDLIEHGQEFIVAH
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCCHHHHHHHHHCCCEEEEEE
GGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKILADVGLVGFPSVGKSTLLSVI
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHH
TSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGLIEGASQGVGLGTQFLRHIERTR
HCCCCCCCEEEEEECCCCCCEEEECCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHE
VILHIIDMSASEGRDPYEDYLAINKELESYNLRLMERPQIIVTNKMDMPESQENLEEFKK
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCCHHHHHHHHH
KLAENYDEFEELPAIFPISGLTKQGLATLLDATAELLDKTPEFLLYDESDMEEEVYYGFD
HHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCC
EEEKAFEISRDDDATWVLSGEKLMKLFNMTNFDRDESVMKFARQLRGMGVDEALRARGAK
CCCHHEEECCCCCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCC
DGDLVRIGKFEFEFVD
CCCEEEEECEEEEECC
>Mature Secondary Structure 
SMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGGNVVFVVDEGLRTLMDF
CCEEEEEEEEEEECCCCCCEEEEEHHCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHH
RYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAETGKVLTDLIEHGQEFIVAH
HHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCCCHHHHHHHHHCCCEEEEEE
GGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKILADVGLVGFPSVGKSTLLSVI
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHH
TSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGLIEGASQGVGLGTQFLRHIERTR
HCCCCCCCEEEEEECCCCCCEEEECCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHE
VILHIIDMSASEGRDPYEDYLAINKELESYNLRLMERPQIIVTNKMDMPESQENLEEFKK
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCCHHHHHHHHH
KLAENYDEFEELPAIFPISGLTKQGLATLLDATAELLDKTPEFLLYDESDMEEEVYYGFD
HHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCCCC
EEEKAFEISRDDDATWVLSGEKLMKLFNMTNFDRDESVMKFARQLRGMGVDEALRARGAK
CCCHHEEECCCCCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCC
DGDLVRIGKFEFEFVD
CCCEEEEECEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA