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The map label for this gene is fba [H]

Identifier: 116515205

GI number: 116515205

Start: 314190

End: 315266

Strand: Direct

Name: fba [H]

Synonym: BCc_279

Alternate gene names: 116515205

Gene position: 314190-315266 (Clockwise)

Preceding gene: 116515204

Following gene: 116515206

Centisome position: 75.46

GC content: 21.36

Gene sequence:

>1077_bases
ATGTGTAAAATTTTAGATATAATAAAACCAGGTGTATTAAATTCTGAAGAAATGAAAATAGTTTTTTTATTAGCTAAAAA
AAAAAAATTTGCTATACCAGCAATTAATTGTATTAACACTGATTCAATAAATATTGTATTAGAAACAGCAGCAAAAATGA
GATCTCCAGTAATTATTCAATTTTCATATAGTGGTTCTCAATTTTTTAGTGGTTTAGGGTTAAATCTTGAAGAAAAAAAA
AAATCAGTTATTGGTGCTATATCTGGAGCTAAATATGTACATATGATTTCAAAGTATTATAAAATTCCTGTTATATTACA
TACAGATCATTGTGATTTTAATCATCTTTATTGGATTAATGATTTATTATCTTATGGTAAAAAATTTTTTAAAAAAAAAA
AACGTCCGTTATTTTCATCACATATGATTGATTTATCTAAAGAAACAATAAAAAAAAATATTATTTTATCTTCTAAATAT
TTAAAAAAAATAACAGAATTAAACATGATGTTAGAAATAGAATTAGGTTGTACCGGTGGAGAAGAAGATGGTATTGATAA
CACAAATATAAATAAAAAACTTCTATATACAGATACTAAAGATATTTATTATGCATTTAAAAAATTAATTAATATTAGTA
ATAATTTTATTATTGCAGCAGCATTTGGAAATATACACGGAGTATATCAACCAGGTAAAATTTCTTTAAAACTTTCTATA
CTAAAAAAAGCTCAAAAATATATTGAGAATATAACAAAATTACCTAATAATCAAATAAATTTTGTTTTTCATGGAGGATC
TGGAACAAGTATAATTGACATACAAAAATCAATTGATTATGGAGTAATAAAATTTAATATTGACACAAATATGCAATGGA
ATTATTGGAAAGGTGTATTAAATTTTTATAAAAACAATAAAAAATTTTTAAATACTCAATTAGGAAATCCATTAGGAAAA
AATCAACCAAATAAAAAATATTACGATCCTAGAGTATGGATCAGATATGCGCAAAAACAATCTATAAAATATTTAAAAAA
AATTTTTATACAATTAAATTCGAAAAATACTTTATAA

Upstream 100 bases:

>100_bases
AACATTACCTATCATTGAAAAAATAAAAAAACTAAATCAATAGCTATTAAATTTAAAAATTCGATAATATTTTTATATTG
ATAGAGGAAGAAAATAAATA

Downstream 100 bases:

>100_bases
ATATTTTAAAATTTTTTTTTACTAGAAAAAAAAAAATAATGTATTATATTTTATTTGTATAATCAAAAAAACAAAAAAAA
ATTAAATATATATTTCTTTA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MCKILDIIKPGVLNSEEMKIVFLLAKKKKFAIPAINCINTDSINIVLETAAKMRSPVIIQFSYSGSQFFSGLGLNLEEKK
KSVIGAISGAKYVHMISKYYKIPVILHTDHCDFNHLYWINDLLSYGKKFFKKKKRPLFSSHMIDLSKETIKKNIILSSKY
LKKITELNMMLEIELGCTGGEEDGIDNTNINKKLLYTDTKDIYYAFKKLINISNNFIIAAAFGNIHGVYQPGKISLKLSI
LKKAQKYIENITKLPNNQINFVFHGGSGTSIIDIQKSIDYGVIKFNIDTNMQWNYWKGVLNFYKNNKKFLNTQLGNPLGK
NQPNKKYYDPRVWIRYAQKQSIKYLKKIFIQLNSKNTL

Sequences:

>Translated_358_residues
MCKILDIIKPGVLNSEEMKIVFLLAKKKKFAIPAINCINTDSINIVLETAAKMRSPVIIQFSYSGSQFFSGLGLNLEEKK
KSVIGAISGAKYVHMISKYYKIPVILHTDHCDFNHLYWINDLLSYGKKFFKKKKRPLFSSHMIDLSKETIKKNIILSSKY
LKKITELNMMLEIELGCTGGEEDGIDNTNINKKLLYTDTKDIYYAFKKLINISNNFIIAAAFGNIHGVYQPGKISLKLSI
LKKAQKYIENITKLPNNQINFVFHGGSGTSIIDIQKSIDYGVIKFNIDTNMQWNYWKGVLNFYKNNKKFLNTQLGNPLGK
NQPNKKYYDPRVWIRYAQKQSIKYLKKIFIQLNSKNTL
>Mature_358_residues
MCKILDIIKPGVLNSEEMKIVFLLAKKKKFAIPAINCINTDSINIVLETAAKMRSPVIIQFSYSGSQFFSGLGLNLEEKK
KSVIGAISGAKYVHMISKYYKIPVILHTDHCDFNHLYWINDLLSYGKKFFKKKKRPLFSSHMIDLSKETIKKNIILSSKY
LKKITELNMMLEIELGCTGGEEDGIDNTNINKKLLYTDTKDIYYAFKKLINISNNFIIAAAFGNIHGVYQPGKISLKLSI
LKKAQKYIENITKLPNNQINFVFHGGSGTSIIDIQKSIDYGVIKFNIDTNMQWNYWKGVLNFYKNNKKFLNTQLGNPLGK
NQPNKKYYDPRVWIRYAQKQSIKYLKKIFIQLNSKNTL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=52.3676880222841, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI87082041, Length=290, Percent_Identity=25.8620689655172, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789526, Length=311, Percent_Identity=24.7588424437299, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=42.1652421652422, Blast_Score=302, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 41174; Mature: 41174

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKILDIIKPGVLNSEEMKIVFLLAKKKKFAIPAINCINTDSINIVLETAAKMRSPVIIQ
CCCHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEE
FSYSGSQFFSGLGLNLEEKKKSVIGAISGAKYVHMISKYYKIPVILHTDHCDFNHLYWIN
EECCCHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCCCCHHHH
DLLSYGKKFFKKKKRPLFSSHMIDLSKETIKKNIILSSKYLKKITELNMMLEIELGCTGG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECHHHHHHHHHCCEEEEEEECCCCC
EEDGIDNTNINKKLLYTDTKDIYYAFKKLINISNNFIIAAAFGNIHGVYQPGKISLKLSI
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCEEEEEHHH
LKKAQKYIENITKLPNNQINFVFHGGSGTSIIDIQKSIDYGVIKFNIDTNMQWNYWKGVL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHH
NFYKNNKKFLNTQLGNPLGKNQPNKKYYDPRVWIRYAQKQSIKYLKKIFIQLNSKNTL
HHHHCCCEEEEHHCCCCCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHEEECCCCCC
>Mature Secondary Structure
MCKILDIIKPGVLNSEEMKIVFLLAKKKKFAIPAINCINTDSINIVLETAAKMRSPVIIQ
CCCHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEE
FSYSGSQFFSGLGLNLEEKKKSVIGAISGAKYVHMISKYYKIPVILHTDHCDFNHLYWIN
EECCCHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCCCCHHHH
DLLSYGKKFFKKKKRPLFSSHMIDLSKETIKKNIILSSKYLKKITELNMMLEIELGCTGG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECHHHHHHHHHCCEEEEEEECCCCC
EEDGIDNTNINKKLLYTDTKDIYYAFKKLINISNNFIIAAAFGNIHGVYQPGKISLKLSI
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCEEEEEHHH
LKKAQKYIENITKLPNNQINFVFHGGSGTSIIDIQKSIDYGVIKFNIDTNMQWNYWKGVL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHH
NFYKNNKKFLNTQLGNPLGKNQPNKKYYDPRVWIRYAQKQSIKYLKKIFIQLNSKNTL
HHHHCCCEEEEHHCCCCCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]