Click here to switch to the map view.

The map label for this gene is ftsJ

Identifier: 116515168

GI number: 116515168

Start: 273579

End: 274208

Strand: Reverse

Name: ftsJ

Synonym: BCc_236

Alternate gene names: 116515168

Gene position: 274208-273579 (Counterclockwise)

Preceding gene: 116515169

Following gene: 116515167

Centisome position: 65.86

GC content: 20.32

Gene sequence:

>630_bases
ATGATTTTAAAAAAAAGAAGTAAAAGTTCTAAAAATTGGTTAAAAAGAAATTTTAATGATCCTTATATTAAAGAAAGAAA
TAAAAAAAAACTAAGATCTAGATCATGGTTTAAATTAAAAGAAATAGATGAATCAGAAAAAATATTTAAAAAAGGAATGA
ATGTTATAGATTTAGGTTCTAATCCAGGAGGTTGGTCAGAATATACTTTAAAAAAAATTGGAAAATCAGGAAAAATTTTT
GCATGTGATATTTTACCTATGCGATTTTTAAAAGATATTGTTTTTTTTTGTGGAGATATATCTAATTCAGATTTCTTAAA
AAAAATATTTTTATTTTTAGACAAATATTCTTGGAATGTAGTTATGTCTGATATATCACCAAATATTTGTGGTTATTCTG
TTATTGATAATTCTAATATGTTTAAATTAAGTAATATTGTATTAAAAATTTCTAGACATGTATTATCAAATAATGGATAT
TTAATAATTAAATTATTTCAAGGTTATGGTTTTAATAAATATATGAAAAAAATTCGAAATATATTTGAATTAGTAAAAAT
TTATAAACCTAATGCTTCTCGTGTCAATTCTCGTGAAGTTTTTATTATAGCTTATGGATGTAAGAAATAA

Upstream 100 bases:

>100_bases
ATTTTTTATATATAATTTAAATTTTATTAAATTAATATTTAAAAATAATTAAATAAAATTTTTATAAATTTTATAATTTA
ATCTTATTAAAAAAAATATA

Downstream 100 bases:

>100_bases
TTTTATTTTATTTTTAATATTATAATATATAGTGGAGATTATCATTTGAATAAAATGGTTAAAAATTTAATTTTATGGTT
TTTTGGTATTTTTTTATTAA

Product: hypothetical protein

Products: NA

Alternate protein names: 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MILKKRSKSSKNWLKRNFNDPYIKERNKKKLRSRSWFKLKEIDESEKIFKKGMNVIDLGSNPGGWSEYTLKKIGKSGKIF
ACDILPMRFLKDIVFFCGDISNSDFLKKIFLFLDKYSWNVVMSDISPNICGYSVIDNSNMFKLSNIVLKISRHVLSNNGY
LIIKLFQGYGFNKYMKKIRNIFELVKIYKPNASRVNSREVFIIAYGCKK

Sequences:

>Translated_209_residues
MILKKRSKSSKNWLKRNFNDPYIKERNKKKLRSRSWFKLKEIDESEKIFKKGMNVIDLGSNPGGWSEYTLKKIGKSGKIF
ACDILPMRFLKDIVFFCGDISNSDFLKKIFLFLDKYSWNVVMSDISPNICGYSVIDNSNMFKLSNIVLKISRHVLSNNGY
LIIKLFQGYGFNKYMKKIRNIFELVKIYKPNASRVNSREVFIIAYGCKK
>Mature_209_residues
MILKKRSKSSKNWLKRNFNDPYIKERNKKKLRSRSWFKLKEIDESEKIFKKGMNVIDLGSNPGGWSEYTLKKIGKSGKIF
ACDILPMRFLKDIVFFCGDISNSDFLKKIFLFLDKYSWNVVMSDISPNICGYSVIDNSNMFKLSNIVLKISRHVLSNNGY
LIIKLFQGYGFNKYMKKIRNIFELVKIYKPNASRVNSREVFIIAYGCKK

Specific function: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit

COG id: COG0293

COG function: function code J; 23S rRNA methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family

Homologues:

Organism=Homo sapiens, GI7019377, Length=210, Percent_Identity=28.5714285714286, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI29029591, Length=177, Percent_Identity=30.5084745762712, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI29029589, Length=177, Percent_Identity=30.5084745762712, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI7110661, Length=177, Percent_Identity=30.5084745762712, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI194097365, Length=175, Percent_Identity=28, Blast_Score=85, Evalue=5e-17,
Organism=Escherichia coli, GI1789569, Length=208, Percent_Identity=44.7115384615385, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17554650, Length=191, Percent_Identity=27.7486910994764, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17553474, Length=212, Percent_Identity=28.7735849056604, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71987550, Length=184, Percent_Identity=27.1739130434783, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71987561, Length=184, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17553860, Length=184, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319796, Length=206, Percent_Identity=31.0679611650485, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319535, Length=209, Percent_Identity=25.3588516746411, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321302, Length=285, Percent_Identity=24.5614035087719, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356387, Length=211, Percent_Identity=31.2796208530806, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI18859957, Length=187, Percent_Identity=25.668449197861, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24647580, Length=194, Percent_Identity=28.3505154639175, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648639, Length=181, Percent_Identity=27.0718232044199, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RLME_BUCCC (Q057J5)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802797.1
- ProteinModelPortal:   Q057J5
- SMR:   Q057J5
- STRING:   Q057J5
- EnsemblBacteria:   EBBUCT00000001212
- GeneID:   4440695
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_236
- eggNOG:   COG0293
- GeneTree:   EBGT00050000008203
- HOGENOM:   HBG398270
- OMA:   SDMAANT
- BioCyc:   BAPH372461:BCC_236-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01547
- InterPro:   IPR015507
- InterPro:   IPR002877
- PANTHER:   PTHR10920
- PIRSF:   PIRSF005461

Pfam domain/function: PF01728 FtsJ

EC number: =2.1.1.166

Molecular weight: Translated: 24507; Mature: 24507

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: NA

Important sites: ACT_SITE 164-164 BINDING 63-63 BINDING 65-65 BINDING 83-83 BINDING 99-99 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKKRSKSSKNWLKRNFNDPYIKERNKKKLRSRSWFKLKEIDESEKIFKKGMNVIDLGS
CCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEHHHCCHHHHHHHCCCCEEEECC
NPGGWSEYTLKKIGKSGKIFACDILPMRFLKDIVFFCGDISNSDFLKKIFLFLDKYSWNV
CCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEE
VMSDISPNICGYSVIDNSNMFKLSNIVLKISRHVLSNNGYLIIKLFQGYGFNKYMKKIRN
EEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
IFELVKIYKPNASRVNSREVFIIAYGCKK
HHHHHHHCCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MILKKRSKSSKNWLKRNFNDPYIKERNKKKLRSRSWFKLKEIDESEKIFKKGMNVIDLGS
CCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEHHHCCHHHHHHHCCCCEEEECC
NPGGWSEYTLKKIGKSGKIFACDILPMRFLKDIVFFCGDISNSDFLKKIFLFLDKYSWNV
CCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEE
VMSDISPNICGYSVIDNSNMFKLSNIVLKISRHVLSNNGYLIIKLFQGYGFNKYMKKIRN
EEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
IFELVKIYKPNASRVNSREVFIIAYGCKK
HHHHHHHCCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA